Alcohol and gastrointestinal oncology

Testino, Gianni

doi:10.4251/wjgo.v2.i8.322

Cited by 12 publications

(7 citation statements)

References 27 publications

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“…Some of these compounds are also very poisonous e.g. ethyl carbamate and some are even carcinogenic (Lachenmeier et al 2009 , 2011 ; Testino et al 2014 ; Testino and Borro 2010 ). Annan et al ( 2003 ) listed 64 volatile compounds produced during the mixed culture fermentation of Ghanaian maize dough consisting of 20 alcohols, 22 carbonyls, 11 esters, 7 acids, 3 phenolic compounds and a furan.…”

Section: Methanol Contamination In Fermented Beveragesmentioning

confidence: 99%

Methanol contamination in traditionally fermented alcoholic beverages: the microbial dimension

Ohimain

2016

SpringerPlus

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Incidence of methanol contamination of traditionally fermented beverages is increasing globally resulting in the death of several persons. The source of methanol contamination has not been clearly established in most countries. While there were speculations that unscrupulous vendors might have deliberately spiked the beverages with methanol, it is more likely that the methanol might have been produced by contaminating microbes during traditional ethanol fermentation, which is often inoculated spontaneously by mixed microbes, with a potential to produce mixed alcohols. Methanol production in traditionally fermented beverages can be linked to the activities of pectinase producing yeast, fungi and bacteria. This study assessed some traditional fermented beverages and found that some beverages are prone to methanol contamination including cachaca, cholai, agave, arak, plum and grape wines. Possible microbial role in the production of methanol and other volatile congeners in these fermented beverages were discussed. The study concluded by suggesting that contaminated alcoholic beverages be converted for fuel use rather than out rightly banning the age—long traditional alcohol fermentation.

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Section: Methanol Contamination In Fermented Beveragesmentioning

confidence: 99%

Methanol contamination in traditionally fermented alcoholic beverages: the microbial dimension

Ohimain

2016

SpringerPlus

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“…As regard to cancers, alcohol consumption has been identified as carcinogenic for the following cancer categories: cancer of the mouth, nasopharrynx, other pharynx and oropharynx, laryngeal cancer, oesophageal cancer, colon and rectum cancer, liver cancer and female breast cancer. In addition, alcohol consumption was considered to be a likely cause of pancreatic cancer too [16,17,29,30,36,37]. The higher the consumption, the greater the risk for these cancers [16–18,36,37].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, alcohol consumption was considered to be a likely cause of pancreatic cancer too [16,17,29,30,36,37]. The higher the consumption, the greater the risk for these cancers [16–18,36,37]. A potential modifiable factor for cancer risk could be the alcohol control consumption [18].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological trends in digestive cancers compared to trends in alcohol consumption. Facts from Romania: correlation or coincidence?

Vălean¹,

Chira²,

Dumitraşcu³

2018

Medicine and Pharmacy Reports

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Background and aimsCancer has emerged as the leading cause of death in human populations. The contribution of alcohol has been highly suspected. The purpose of this paper was to analyze the time trend of digestive cancers in Romania, in terms of mortality rates (1955–2012), and incidence rates (2008–2012), and the alcohol consumption data (1961–2010), aiming to find out if there is any association.MethodsThe data on six more common digestive cancers mortality rates (1955–2012) and incidence rates (2008–2012) were obtained from the historical and recent country statistics and publications of International Agency for Research on Cancer (IARC)/World Health Organisation (WHO), as age-standardized rate expressed per 100,000 population (ASRw). Data on alcohol consumption were obtained from the statistics and publications of WHO and United European Gastroenterology (UEG), as liters of pure alcohol/year.ResultsBetween 1955–2012, the ASRw of mortality registered an increase of the cancers of the esophagus in M (from 2.03 to 3.90), and of colorectal cancer in both sexes (from 4.65 to 18.20 in M, and from 4.57 to 9.70 in F). Between 1980–2012, an increasing trend of mortality was registered, in both sexes, for the cancers of the pancreas (from 5.50 to 9.30 in M and from 2.92 to 5.10 in F) and liver (from 1.77 to 11.00, in M, and from 0.83 to 4.20 in F). In terms of incidence, between 2008–20012, an increasing trend of ASRw was registered for the cancers of the esophagus in M (from 3.90 to 4.30), gastric cancer in M (from 15.90 to 16.30), colorectal cancer in both sexes (from 27.60 to 34.50 in M and from 19.00 to 20.20 in F), pancreatic cancer in F (form 5.20 to 5.90), and liver cancer in M (from 8.10 to 9.20). Alcohol consumption per capita (liters pure alcohol/year) increased in the same period, from an average of 5 in 1961, to 12.8 in 2003–2005, and to 14.4 in 2008–2010.ConclusionsGiven the parallel increase of some digestive cancers and alcohol consumption registered in our area, alcohol could represent more than a coincidence.

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“…The carcinogenic effects of alcohol are possibly mediated through different pathways; e.g., formation of acetaldehyde, induction of cytochrome P450 2E1 (CYP2E1activation of various procarcinogens), nutritional deficiencies, alterations of immunity, weight gain (obesity), increase in estrogen levels, etc. [19][20][21]. Interestingly, there is a strong synergism between alcohol consumption and hepatitis C virus (HCV) in liver pathology [22].…”

Section: Alcohol and Cancermentioning

confidence: 99%

Pathobiology of cancer and clinical biochemistry

Barreto¹,

Armstrong²,

Doğan

et al. 2016

J Pediatr Biochem

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Early diagnosis of cancer clearly reduces morbidity and mortality, and a sizable number of cancers could be prevented at the secondary level with appropriate diagnostic tools. In early detection, biochemical analyses are highly supportive of the cytological and/or histopathological assessments. Among children, cancers probably originate from altered signaling pathways attributable to developmental genetic disorders. In adults, generally preventable risk factors, e.g., cigarette smoking, infections, unhealthy lifestyle and obesity, create a state of inflammation and associated oxidative imbalance, which may progress to malignancy. Pathological mechanisms of cancer are associated with abnormal expressions of various endogenous molecules that can be used as tumor biomarkers. Evaluation of such markers in different phases along the disease course plays a crucial role in clinical management and prognosis. Definitely, the current trend of active research on neoplastic mechanisms will help the clinical biochemistry laboratories to provide a better service.

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Alcohol and gastrointestinal oncology

Cited by 12 publications

References 27 publications

Methanol contamination in traditionally fermented alcoholic beverages: the microbial dimension

Methanol contamination in traditionally fermented alcoholic beverages: the microbial dimension

Epidemiological trends in digestive cancers compared to trends in alcohol consumption. Facts from Romania: correlation or coincidence?

Pathobiology of cancer and clinical biochemistry

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