Alcohol and Human Health: What Is the Evidence?

Hendriks, H.

doi:10.1146/annurev-food-032519-051827

Cited by 75 publications

(63 citation statements)

References 140 publications

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“…These categories include: (1) long‐term abstinence from alcohol (LA); (2) binge drinking (BD), intake of an excessive, large amount of alcohol over a short period of time (within a 2‐h time period on one occasion) with no intention to stop drinking (two to three times per month with ≥4 and 5 drinks for females and males, respectively); (3) long‐term damaging alcohol drinking that exceeds the safe drinking dosage recommend by WHO (LD), with alcohol intake of <4 to ≥3 drinks and <5 to ≥4 drinks per day for females and males, respectively; (4) long‐term low dosage drinking, involving the consumption maximum two drinks of alcohol per day for both females and males (LDD); and (5) long‐term heavy drinking (HD), alcohol intake ≥5 drinks per day, regardless of sex. Previous studies reported that alcohol‐drinking patterns are associated with different risks to ARBD, physiological alcohol‐related diseases, financial burdens of ARBD (Esser et al., 2020; Hendriks, 2020; Liu, 2020; Silveira et al., 2020). Drinking alcohol impairs specific brain regions, including the occipital lobe, parietal lobe, frontal cortex, temporal lobe, cingulate cortex, and thalamus.…”

Section: Introductionmentioning

confidence: 99%

Differential effects of alcohol‐drinking patterns on the structure and function of the brain and cognitive performance in young adult drinkers: A pilot study

Guo

Yan²,

Chen

et al. 2021

Brain and Behavior

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Introduction This study was aimed to determine how different patterns of alcohol consumption drive changes to brain structure and function and their correlation with cognitive impairments in young adult alcohol drinkers. Methods In this study, we enrolled five groups participants and defined as: long‐term abstinence from alcohol (LA), binge drinking (BD), long‐term low dosage alcohol consumption but exceeding the safety drinking dosage (LD), long‐term alcohol consumption of damaging dosage (LDD), and long‐term heavy drinking (HD). All participants underwent magnetic resonance imaging (MRI) and functional MRI (fMRI) to acquire data on brain structure and function, including gray matter volume (GMV), fractional amplitude of low‐frequency fluctuation (fALFF), regional homogeneity (ReHo), functional connectivity (FC), and brain network properties. The cognitive ability was evaluated with the California Verbal Learning Test (CVLT), intelligence quotient (IQ), and short delay free recall (SDFR). Results Compared to LA, GMV significantly decreased in the brain regions in VN, SMN, and VAN in the alcohol‐drinking groups (BD, LD, LDD, and HD). ReHo was significantly enhanced in the brain regions in VN, SMN, and VAN, while fALFF significantly increased in the brain regions in VN and SMN. The number of intra‐ and inter‐modular connections within networks (VN, SMN, sensory control network [SCN], and VAN) and their connections to other modules were abnormally changed. These changes adversely affected cognition (e.g., IQ, CVLT, SDFR). Conclusion Despite the small sample size, this study provides new evidence supporting the need for young people to abstain from alcohol to protect their brains. These findings present strong reasoning for updating anti‐alcohol slogans and guidelines for young people in the future.

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Section: Introductionmentioning

confidence: 99%

Differential effects of alcohol‐drinking patterns on the structure and function of the brain and cognitive performance in young adult drinkers: A pilot study

Guo

Yan²,

Chen

et al. 2021

Brain and Behavior

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“…Such studies not only point to the mechanism of protection ( Brien et al ., 2011 ), but also indicate that the mechanism is very similar when consuming wine, beer or spirits. Main effect of moderate alcohol consumption appears to be the inhibition of the atherosclerotic process ( Hendriks, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…Long-term excessive drinking and binge drinking also result in many negative health effects. However, short-term and long-term light to moderate alcohol consumption have been associated with several positive health outcomes ( Hendriks, 2020 ). Consequently, many countries have guidelines advising low to moderate alcohol consumption aimed at reducing the health burden caused by the misuse of alcohol ( WHO, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Associations between Low to Moderate Consumption of Alcoholic Beverage Types and Health Outcomes: A Systematic Review

Estruch

Hendriks²

2021

Alcohol and Alcoholism

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Aims There is limited research comparing light to moderate wine, beer and spirits consumption and their impact on long-term health. This systematic review aims to investigate the studies published in the past 10 years and qualitatively assess the similarities and differences between the three main beverages, when consumed at a low to moderate level, for their associations with various health outcomes. Methods A systematic search was conducted for comparative studies published in English language (2010 to mid-2021) of beverage-specific low to moderate alcohol consumption associated with all-cause mortality, cancer, cardiovascular disease and diabetes mellitus type II. Results The search yielded a total of 24 studies (8 meta-analyses; 15 prospective studies and 1 pooled analysis). Overall, most studies showed similar associations of different alcoholic beverages with chronic conditions, including all-cause mortality, many types of cancer, cardiovascular disease and diabetes mellitus type II. Not all data are consistent. Some studies show more beneficial or detrimental effects of wine than other beverage types, whereas other studies show such effects for other beverages. Conclusion Moderate consumption of one specific alcoholic beverage (wine, beer or spirits) may not be consistently associated with higher or lower risks for common health outcomes as compared with moderate consumption of any of the other alcoholic beverages.

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“…However, alcohol also possesses both toxic and intoxicating properties. Alcohol is a toxic substance that is foreign to the body (not produced by the body), and it can lead to serious poisonous effects, especially when taken in high concentrations [4]. In general, the harmfulness of alcohol consumption can be related to the total volume of irregular heavy drinking [5,6].…”

Section: Introductionmentioning

confidence: 99%

Alcohol Consumption Patterns: A Systematic Review of Demographic and Sociocultural Influencing Factors

Khamis

Salleh

Karim

et al. 2022

IJERPH

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Background: Excessive alcohol consumption has negative effects not only on the drinkers’ health but also on others around them. Previous studies suggest that excessive alcohol consumption can be related to a combination of factors such as age, family background, religiosity, etc. Investigating and clarifying these roots of alcohol consumption is crucial so that the right type of interventions can be designed in a specific and targeted manner. Objectives: This work was conducted as a systematic review to reveal the factors associated with alcohol consumption and to heighten the understanding of the differences among various communities and segments of the population regarding their usage of alcohol. Data sources: A systematic search of Web of Science, PubMed, ScienceDirect, and Google Scholar was performed. Results: Forty-five studies were included in the review after excluding irrelevant records and duplicates. Conclusions: Alcohol consumption patterns can be associated with several factors related to communities and individuals, and our review revealed demographic factors, including age and proximity to alcohol outlets, as well as social factors, including family background, socioeconomic background, and religious influence. These findings can be used to establish a guideline for further studies in understanding alcohol consumption patterns among individuals according to their personal characteristics and sociocultural backgrounds.

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Alcohol and Human Health: What Is the Evidence?

Cited by 75 publications

References 140 publications

Differential effects of alcohol‐drinking patterns on the structure and function of the brain and cognitive performance in young adult drinkers: A pilot study

Differential effects of alcohol‐drinking patterns on the structure and function of the brain and cognitive performance in young adult drinkers: A pilot study

Associations between Low to Moderate Consumption of Alcoholic Beverage Types and Health Outcomes: A Systematic Review

Alcohol Consumption Patterns: A Systematic Review of Demographic and Sociocultural Influencing Factors

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