Alcohol and illicit drug use among potential HIV vaccine efficacy trial volunteers along Lake Victoria, Uganda

Ssekandi, I; Ssetaala, Ali; Mpendo, J; Nanvubya, Annet; Nielsen, Leslie; Kiwanuka, Noah

doi:10.1186/1742-4690-9-s2-p219

Cited by 7 publications

(5 citation statements)

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“…This research extends the previous literature linking alcohol consumption to HIV infection and sexual risk in Ugandan fishing communities (Asiki, et al, 2011;Kiwanuka, et al, 2017;Seeley, et al, 2012;Ssekandi, et al, 2012) by examining both patterns of alcohol consumption and alcohol-related problems in these associations. Our study suggests the association between alcohol and HIV risk may be driven by the co-occurrence of potentially hazardous levels of alcohol consumption and alcohol-related problems, such as dependence symptoms and harms from alcohol use, rather than by lower-risk drinking behavior or only either hazardous use or alcohol-related problems.…”

Section: Discussionsupporting

confidence: 63%

“…While hazardous drinking is correlated with alcohol dependence (Caetano, Tam, Greenfield, Cherpitel, & Midanik, 1997;Dawson, 1994), and an association between alcohol dependence and risky sexual behavior has been reported (Cavazos-Rehg et al, 2007;Krupitsky et al, 2005), studies are needed that further characterize how hazardous alcohol use and, more broadly, alcohol-related problems, independently and jointly are associated with HIV status. Few studies (Tumwesigye et al, 2012) in Ugandan fishing communities in particular have examined alcohol use in relation to HIV outcomes beyond categorical and dichotomous alcohol variables (any/high vs. none/ low) (Asiki, et al, 2011;Seeley, et al, 2012;Ssekandi, et al, 2012). Thus, the purpose of the present study was to examine how alcohol consumption patterns and experiencing problems related to alcohol-use such as psychological, physical, and social harms, and symptoms of dependence are associated with HIV status in fishing communities in Uganda.…”

Section: Introductionmentioning

confidence: 96%

“…Alcohol use also occurs at high rates in this setting (Asiki et al, 2011;Tumwesigye et al, 2012). Research among fisherfolk has found alcohol consumption to be associated with HIV infection as well as risky sexual behaviors (Asiki, et al, 2011;Kiwanuka et al, 2017;Seeley et al, 2012;Ssekandi et al, 2012). Moreover, qualitative research suggests alcohol is commonly exchanged between fishermen and commercial sex workers (CSWs) and used during sex, heightening risk for unprotected sex while intoxicated (Sileo, Kintu, Chanes-Mora, & Kiene, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Hazardous alcohol consumption and alcohol-related problems are associated with unknown and HIV-positive status in fishing communities in Uganda

et al. 2018

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In Uganda, alcohol consumption is associated with higher HIV prevalence. However, research is needed to better understand how different patterns of alcohol consumption and alcohol-related problems may drive this association. In this cross-sectional study, we examined how hazardous alcohol use and alcohol-related problems such as psychological, physical, and social harms are associated with HIV status in fishing communities in Uganda. 300 (132 male, 168 female) residents of fishing communities in Uganda (75 participants from each of the following occupational groups: fishmongers, alcohol sellers, commercial sex workers (CSW), and fishermen) completed an interviewer-assisted computerized interview. We captured information on sociodemographics and HIV testing history. Prior 12-month hazardous alcohol consumption patterns and alcohol-related problems were assessed with the AUDIT and AUDADIS. 19.7%, 58.0%, and 23.3% of the sample reported being HIV positive, being HIV negative from a test within the prior 12 months, and not knowing their HIV status respectively. 18.7% reported the co-occurrence of hazardous alcohol consumption patterns and alcohol-related problems. 7.7% reported either hazardous alcohol consumption patterns or alcohol-related problems. Compared to non-drinkers, those with co-occurring hazardous consumption and alcohol-related problems had greater odds of being HIV positive (adjOR 2.75, 95% CI 1.17-6.43) and of unknown HIV status (adjOR 3.35, 95% CI 1.52-7.42). Reporting only hazardous consumption levels, only alcohol-related problems, or low-risk drinking, did not increase the odds of being HIV positive or of unknown status. Among those not HIV positive, those with co-occurring hazardous consumption and alcohol-related problems had greater odds of never having had an HIV test (adjOR 3.78, 95% CI 1.63-8.68). The co-occurrence of hazardous alcohol use and alcohol related problems appears to be a prominent risk factor for HIV infection, not knowing one's HIV status, and never testing for HIV in this setting.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Hazardous alcohol consumption and alcohol-related problems are associated with unknown and HIV-positive status in fishing communities in Uganda

et al. 2018

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“…Concurrent with the apparent increase in substance use in SSA, human immunodeficiency virus (HIV) remains a major public health problem, with young women aged 15-24 years and people who inject drugs disproportionately affected [7]. In a recent systematic review, we showed that in SSA, information on the burden of alcohol misuse and illicit drug use is limited, especially among young people belonging to certain occupational groups (i.e., sex workers, miners, truckers, fishing communities, uniformed personnel and motorcycle taxi riders) known to be at increased risk of HIV acquisition [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Alcohol Misuse and Illicit Drug Use Among Young People Aged 15–24 Years in Fishing Communities in Uganda

Kuteesa

Weiss

Cook

et al. 2020

IJERPH

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Background: We determined the prevalence of and risk factors for alcohol misuse and illicit drug use among young Ugandans in fishing communities, a recognised “key population” for human immunodeficiency virus (HIV) infection. Methods: We conducted a cross-sectional survey among young people (15–24 years) in fishing communities in Koome, Uganda, in December 2017–July 2018. Using Audio-Assisted Self-Interviewing, we collected data on socio-demographic characteristics and alcohol use, including the Alcohol Use Disorders Identification Test (AUDIT) and timeline follow-back calendar (TLFB). Blood samples were analysed for HIV, herpes simplex virus 2 (HSV2), and Phosphatidyl ethanol (PEth 16:0/18:1). Urine samples were analysed for illicit drugs. Results: Among 1281 participants (52.7% male, mean age 20 years), 659 (51.4%) reported ever drinking alcohol, 248 (19.4%) had 12-month-AUDIT ≥ 8, and 261 (20.5%) had whole-blood PEth 16:0/18:1 concentration ≥ 20 ng/mL, indicating significant consumption. In multivariable analyses, PEth 16:0/18:1 ≥ 20ng/mL, AUDIT ≥ 8 and binge drinking (≥6 standard drinks per drinking occasion in the previous month from TLFB) were all strongly associated with older age, low education, smoking, and HSV2. Illicit drug use prevalence was 5.2% and was associated with older age, low education, being single, and smoking. Conclusion: Levels of alcohol misuse were high among young people in fishing communities and associated with HSV2, a proxy for risky sexual behaviour. Alcohol and illicit drug harm reduction services and HIV prevention programs in Uganda should prioritise young fisherfolk.

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“…There also seemed to be an increasing interest in substance abuse, mental health, and noncommunicable diseases among practitioners and scholars of global health (Beaglehole and Bonita 2009). A small but expanding number of studies were documenting linkages between high levels of alcohol consumption and morbidity and mortality from diseases like HIV (Bajunirwe, Bangsberg, and Sethi 2013;Wolff et al 2006;Kagaayi et al 2014;Karamagi et al 2006;Kerridge et al 2014;Kiwanuka et al 2013;Ssekandi et al 2012;Martinez et al 2008;Mbulaiteye et al 2000;Musinguzi et al 2014), tuberculosis (Kirenga et al 2015;Macintyre 2011), cancer (Cook 1971;Qian et al 2014), and alcohol-related liver diseases (Schwartz et al 2014). Researchers were also exploring links between excessive alcohol use and a variety of social problems including child maltreatment (Culbreth et al 2021), intimate partner violence (Zablotska et al 2009), and homelessness (Swahn et al 2018).…”

Section: Drinking Problemsmentioning

confidence: 99%

Higher Powers: Alcohol and After in Uganda’s Capital City

Scherz,

Mpanga,

Namirembe

2024

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Higher Powers draws on four years of collaborative fieldwork carried out with Ugandans working to reconstruct their lives after attempting to leave behind problematic alcohol use. Given the relatively recent introduction of biomedical ideas of alcoholism and addiction in Uganda, most of these people have used other therapeutic resources, including herbal aversion therapies, engagements with balubaale spirits, and forms of deliverance and spiritual warfare practiced in Pentecostal churches. While these methods are at times severe, they contain within them understandings of the self and practices of sociality that point away from models of addiction as a chronic relapsing brain disease and towards the possibility of release. Higher Powers offers a reconceptualization of addiction and recovery that may prove relevant well beyond Uganda.

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Alcohol and illicit drug use among potential HIV vaccine efficacy trial volunteers along Lake Victoria, Uganda

Cited by 7 publications

References 0 publications

Hazardous alcohol consumption and alcohol-related problems are associated with unknown and HIV-positive status in fishing communities in Uganda

Hazardous alcohol consumption and alcohol-related problems are associated with unknown and HIV-positive status in fishing communities in Uganda

Epidemiology of Alcohol Misuse and Illicit Drug Use Among Young People Aged 15–24 Years in Fishing Communities in Uganda

Higher Powers: Alcohol and After in Uganda’s Capital City

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