Alcohol and oestrogen metabolites in postmenopausal women in the Women’s Health Initiative Observational Study

Playdon, Mary C.; Coburn, Sally B; Moore, Stephen; Brinton, Louise A.; Wentzensen, Nicolas; Anderson, Garnet L.; Wallace, Robert B.; Falk, Roni T.; Pfeiffer, Ruth M.; Xu, Xia; Trabert, Britton

doi:10.1038/bjc.2017.419

Cited by 18 publications

(7 citation statements)

References 51 publications

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“…Although there is substantial evidence that moderate levels of physical activity, bearing children, delayed menopause and eating foods that are rich in lutein (fruits and vegetables) can protect against obesity and the associated conditions of hyperinsulinaemia and metabolic syndrome and the risk of developing type 2 diabetes mellitus [ 323 ] and that alcohol consumption may increase, and coffee and tea consumption may reduce, the risk of EC [ 307 , 326 , 403 ], these interventions have not yet filtered through to the patients at risk. More evidence is thus required for meta-analysis of the individual factors that prevent EC incidence [ 4 ] and that will come from further study.…”

Section: Discussionmentioning

confidence: 99%

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

Yasin

Taylor

Ayakannu

2021

Cancers

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Endometrial cancer is the most common cancer affecting the reproductive organs of women living in higher-income countries. Apart from hormonal influences and genetic predisposition, obesity and metabolic syndrome are increasingly recognised as major factors in endometrial cancer risk, due to changes in lifestyle and diet, whereby high glycaemic index and lipid deposition are prevalent. This is especially true in countries where micronutrients, such as vitamins and minerals are exchanged for high calorific diets and a sedentary lifestyle. In this review, we will survey the currently known lifestyle factors, dietary requirements and hormonal changes that increase an individual’s risk for endometrial cancer and discuss their relevance for clinical management. We also examine the evidence that everyday factors and clinical interventions have on reducing that risk, such that informed healthy choices can be made. In this narrative review, we thus summarise the dietary and lifestyle factors that promote and prevent the incidence of endometrial cancer.

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Section: Discussionmentioning

confidence: 99%

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

Yasin

Taylor

Ayakannu

2021

Cancers

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“…Investigators focused on health-enhancing behaviours and onanti-health activities. They examined the impact of a single activity and of several interacting activities on women's health [12,[16][17][18][19][20]. However, there are only few studies on understanding of the concept of health by women in the postmenopausal period, and there are not so many analyses of the whole spectrum of health behaviours undertaken by this group, which were measured by standardized questionnaires.…”

Section: Introductionmentioning

confidence: 99%

Perception of health, health behaviours and the use of prophylactic examinations in postmenopausal women

Pilewska–Kozak¹,

Pałucka²,

Łepecka–Klusek³

et al. 2020

BMC Women's Health

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Background: Pro-health behaviours aim at disease prevention, recovery from an illness and maintenance of good health in a physical, mental and social sphere. The study had two main objectives: (a) to analyse health behaviours of postmenopausal women and their understanding of the notion of health, and (b) to analyse the relationship between individual categories of health behaviours and prophylactic activities undertaken by postmenopausal women. Methods: A cross-sectional study was conducted among a convenience sample of 510 postmenopausal women. Three study instruments were used: an original questionnaire and two instruments designed by Juczyński: the List of Health Criteria and the Health Behaviour Inventory. Results: In the view of the respondents health was primarily synonymous with a feature, because the following three associations were given the highest priority when defining health: to be healthy means 'have all body parts functioning well' (M = 1.82), 'do not experience any physical problems' (M = 1.43) and 'not be sick, only occasionally suffer from flu, cold or indigestion'. The score for health behaviours was average (M = 86.18). The highest score was achieved in the area of prophylactic behaviours. General indicator of health-related behaviours was higher in women who rated their health as very good (p < 0.05). Women whose general indicator of health-related behaviours was higher regularly performed prophylactic gynaecological examinations (p < 0.05). Conclusions: Results showed that women after menopause treat health mainly as a feature of their body and condition specific for this period of life. The analysis of postmenopausal women's health behaviours and their perception of health helped to identify areas that require the focus of medical personnel in regard to health promotion and prophylaxis. The average general indicator of health-related behaviours is positive for this group of women as it shows that they care about their health, especially in terms of prophylaxis.

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“…In the Primary Prevention of Cardiovascular Disease with a Mediterranean Diet trial (PREDIMED), participants randomized to follow a Mediterranean diet (high intake of fruit, vegetable, grains, beans, nuts and seeds and low to moderate intake of dairy, eggs, fish and poultry) supplemented with olive oil showed significantly reduced plasma BCAA levels after one year compared to the low-fat control dietary intervention 46 . However, BCAAs were not identified as markers of dietary patterns 47 or dietary intake 48 , suggesting that the role of BCAAs in breast cancer etiology may reflect mechanisms beyond their dietary intake.…”

Section: Discussionmentioning

confidence: 98%

Branched chain amino acids and risk of breast cancer

Zeleznik

Balasubramanian

Ren

et al. 2020

Preprint

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Circulating branched chain amino acid (BCAA) levels reflect metabolic health and dietary intake. However, associations with breast cancer are unclear. We evaluated circulating BCAA levels and breast cancer risk within the Nurses' Health Study (NHS) and NHSII (1,997 cases, 1,997 matched controls). 592 NHS women donated two blood samples 10 years apart. We estimate odds ratios (OR) and 95% confidence intervals (CI) of breast cancer risk in multivariable logistic regression models. We conducted an external validation with secondary analyses in the Women's Health Study (WHS; 1,297 cases). Among NHSII participants (predominantly premenopausal at blood collection), elevated circulating BCAA levels were associated with lower breast cancer risk (e.g., isoleucine highest vs. lowest quartile, multivariable OR(95% CI)=0.86(0.65-1.13), p-trend=0.20), with significant linear trends among fasting samples (e.g., isoleucine OR(95% CI)=0.74(0.53-1.05), p-trend=0.05). In contrast, among postmenopausal women, proximate measures (<10y from blood draw) were associated with increased breast cancer risk (e.g., isoleucine OR(95% CI)=1.63(1.12-2.39), p-trend=0.01), with stronger associations among fasting samples (OR(95% CI)=1.73(1.15-2.61), p-trend=0.01). Distant measures (10-20y since blood draw) were not associated with risk. In the WHS, a positive association was observed for distant measures of leucine among postmenopausal women: OR(95% CI)=1.31(0.97-1.75), p-trend=0.05. Although elevated circulating BCAA levels were associated with lower breast cancer risk among premenopausal NHSII women and higher risk of postmenopausal breast cancer in NHS (<10y from blood draw), independent of established risk factors, including adiposity, results were not validated in WHS. Additional studies are needed to understand the complex relationship between BCAAs, menopausal status, and risk of breast cancer.

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Alcohol and oestrogen metabolites in postmenopausal women in the Women’s Health Initiative Observational Study

Abstract: Among postmenopausal women, the association between alcohol intake and parent oestrogen, but not oestrogen metabolite concentrations, may be influenced by MHT and type of alcohol.

Cited by 18 publications

References 51 publications

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

A Narrative Review of the Role of Diet and Lifestyle Factors in the Development and Prevention of Endometrial Cancer

Perception of health, health behaviours and the use of prophylactic examinations in postmenopausal women

Branched chain amino acids and risk of breast cancer

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