Alcohol and Risk of Breast Cancer

Narod, Steven A.

doi:10.1001/jama.2011.1589

Cited by 17 publications

(10 citation statements)

References 11 publications

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“…Combined with tobacco use, alcohol consumption increases the risk of cancers of the mouth, larynx, and esophagus far more than the independent effect of either drinking or smoking (38). Breast cancer risk increases with increasing intake of alcohol (61). According to 2012 nationwide data, the prevalence of heavier drinking (defined as 2 or more drinks per day for men and 1 or more for women) was around 5% for adults ages 18 years and older (51).…”

Section: Nutritionmentioning

confidence: 99%

Prevalence of Major Risk Factors and Use of Screening Tests for Cancer in the United States

Fedewa

Sauer

Siegel

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Much of the suffering and death from cancer could be prevented by more systematic efforts to reduce tobacco use, improve diet, increase physical activity, reduce obesity, and expand the use of established screening tests. Monitoring the prevalence of cancer risk factors and screening is important to measure progress and strengthen cancer prevention and early detection efforts. In this review article, we provide recent prevalence estimates for several cancer risk factors, including tobacco, obesity, physical activity, nutrition, ultraviolet radiation exposure as well as human papillomavirus and hepatitis B vaccination coverage and cancer screening prevalence in the United States. In 2013, cigarette smoking prevalence was 17.8% among adults nationally, but ranged from 10.3% in Utah to 27.3% in West Virginia. In addition, 15.7% of U.S. high school students were current smokers. In 2011-2012, obesity prevalence was high among both adults (34.9%) and adolescents (20.5%), but has leveled off since 2002. About 20.2% of high school girls were users of indoor tanning devices, compared with 5.3% of boys. In 2013, cancer screening prevalence ranged from 58.6% for colorectal cancer to 80.8% for cervical cancer and remains low among the uninsured, particularly for colorectal cancer screening where only 21.9% of eligible adults received recommended colorectal cancer screening. Cancer Epidemiol Biomarkers Prev; 24(4); 637-52.Ó2015 AACR.

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Section: Nutritionmentioning

confidence: 99%

Prevalence of Major Risk Factors and Use of Screening Tests for Cancer in the United States

Fedewa

Sauer

Siegel

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Alcohol induced cancers may be restricted to estrogen receptor-positive tumors ( 2 , 7 ). Even low levels of alcohol consumption (3–6 drinks/week) are associated with a small increase in breast cancer risk, with the most consistent measure being cumulative alcohol intake throughout adult life combined with binge drinking ( 3 – 5 ).…”

Section: Introductionmentioning

confidence: 99%

Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features

Gelfand

Vernet

Bruhn

et al. 2016

International Journal of Oncology

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Alcoholism is associated with breast cancer incidence and progression, and moderate chronic consumption of ethanol is a risk factor. The mechanisms involved in alcohol's oncogenic effects are unknown, but it has been speculated that they may be mediated by acetaldehyde. We used the immortalized normal human epithelial breast cell line MCF-12A to determine whether short- or long-term exposure to ethanol or to acetaldehyde, using in vivo compatible ethanol concentrations, induces their oncogenic transformation and/or the acquisition of epithelial mesenchymal transition (EMT). Cultures of MCF-12A cells were incubated with 25 mM ethanol or 2.5 mM acetaldehyde for 1 week, or with lower concentrations (1.0–2.5 mM for ethanol, 1.0 mM for acetaldehyde) for 4 weeks. In the 4-week incubation, cells were also tested for anchorage-independence, including isolation of soft agar selected cells (SASC) from the 2.5 mM ethanol incubations. Cells were analyzed by immunocytofluorescence, flow cytometry, western blotting, DNA microarrays, RT/PCR, and assays for miRs. We found that short-term exposure to ethanol, but not, in general, to acetaldehyde, was associated with transcriptional upregulation of the metallothionein family genes, alcohol metabolism genes, and genes suggesting the initiation of EMT, but without related phenotypic changes. Long-term exposure to the lower concentrations of ethanol or acetaldehyde induced frank EMT changes in the monolayer cultures and in SASC as demonstrated by changes in cellular phenotype, mRNA expression, and microRNA expression. This suggests that low concentrations of ethanol, with little or no mediation by acetaldehyde, induce EMT and some traits of oncogenic transformation such as anchorage-independence in normal breast epithelial cells.

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“…Excess alcohol consumption has many adverse effects on health including liver cirrhosis [1], cancer of the oral cavity, pharynx, larynx, oesophagus, liver [2] and breast [3], high blood pressure [4] and stroke [5]. There is also an increased risk of harm resulting from violence including homicide [6], suicide [7], road traffic accidents [8], domestic violence [9], and attendance at Emergency Departments and Minor Injuries Units for treatment of violence-related injuries [10].…”

Section: Introductionmentioning

confidence: 99%

Change in alcohol outlet density and alcohol-related harm to population health (CHALICE)

et al. 2012

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BackgroundExcess alcohol consumption has serious adverse effects on health and violence-related harm. In the UK around 37% of men and 29% of women drink to excess and 20% and 13% report binge drinking. The potential impact on population health from a reduction in consumption is considerable. One proposed method to reduce consumption is to reduce availability through controls on alcohol outlet density. In this study we investigate the impact of a change in the density of alcohol outlets on alcohol consumption and alcohol-related harms to health in the community.Methods/DesignA natural experiment of the effect of change in outlet density between 2005–09, in Wales, UK; population 2.4 million aged 16 years and over. Data on outlets are held by the 22 local authorities in Wales under The Licensing Act 2003.The study outcomes are change in (1) alcohol consumption using data from annual Welsh Health Surveys, (2) alcohol-related hospital admissions using the Patient Episode Database for Wales, (3) Accident & Emergency department attendances between midnight–6am, and (4) alcohol-related violent crime against the person, using Police data.The data will be anonymously record-linked within the Secure Anonymised Information Linkage Databank at individual and 2001 Census Lower Super Output Area levels. New methods of network analysis will be used to estimate outlet density. Longitudinal statistical analysis will use (1) multilevel ordinal models of consumption and logistic models of admissions and Accident & Emergency attendance as a function of change in individual outlet exposure, adjusting for confounding variables, and (2) spatial models of the change in counts/rates of each outcome measure and outlet density. We will assess the impact on health inequalities and will correct for population migration.DiscussionThis inter-disciplinary study requires expertise in epidemiology and public health, health informatics, medical statistics, geographical information science, and research into alcohol-related violence. Information governance requirements for the use of record-linked data have been approved together with formal data access agreements for the use of the Welsh Health Survey and Police data.The dissemination strategy will include policy makers in national and local government. Public engagement will be through the Clinical Research Collaboration-Cymru "Involving People" network, which will provide input into the implementation of the research.

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Alcohol and Risk of Breast Cancer

Cited by 17 publications

References 11 publications

Prevalence of Major Risk Factors and Use of Screening Tests for Cancer in the United States

Prevalence of Major Risk Factors and Use of Screening Tests for Cancer in the United States

Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features

Change in alcohol outlet density and alcohol-related harm to population health (CHALICE)

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