Alcohol and the Cardiovascular System

Regan, Timothy J.

doi:10.1001/jama.1990.03450030101041

Cited by 140 publications

(76 citation statements)

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“…3,[8][9][10][11] Heavy drinking and alcoholism not only lead to medical problems but are also serious social concerns. However, alcohol also seems to have beneficial effects, including the prevention of ischemic heart disease.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that cardiovascular and all-cause mortality is lower in light drinkers compared with nondrinkers. 3,[8][9][10][11][12] The purpose of this article is to review physio-pathological effects of alcohol on cardiovascular and related systems and to describe its role in hypertension and cardiovascular disease. I will outline the cardiovascular actions of alcohol, the effects of alcohol on BP and hypertension, including changes in 24-h BP, and the relationship between alcohol and cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

Kawano

2010

Hypertens Res

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Alcohol has complex effects on the cardiovascular system. The purpose of this article is to review physio-pathological effects of alcohol on cardiovascular and related systems and to describe its role in hypertension and cardiovascular disease. The relationship between alcohol and hypertension is well known, and a reduction in the alcohol intake is widely recommended in the management of hypertension. Moreover, alcohol has both pressor and depressor actions. The latter actions are clear in Oriental subjects, especially in those who show alcohol flush because of the genetic variation in aldehyde dehydrogenase activity. Repeated alcohol intake in the evening causes an elevation in daytime and a reduction in nighttime blood pressure (BP), with little change in the average 24-h BP in Japanese men. Thus, the hypertensive effect of alcohol seems to be overestimated by the measurement of casual BP during the day. Heavy alcohol intake seems to increase the risk of several cardiovascular diseases, such as hemorrhagic stroke, arrhythmia and heart failure. On the other hand, alcohol may act to prevent atherosclerosis and to decrease the risk of ischemic heart disease, mainly by increasing HDL cholesterol and inhibiting thrombus formation. A J-or U-shaped relationship has been observed between the level of alcohol intake and risk of cardiovascular mortality and total mortality. It is reasonable to reduce the alcohol intake to less than 30 ml per day for men and 15 ml per day for women in the management of hypertension. As a small amount of alcohol seems to be beneficial, abstinence from alcohol is not recommended to prevent cardiovascular disease. INTRODUCTIONAlcohol has complex effects on the cardiovascular system. The relationship between alcohol and hypertension is well known, and a restriction of alcohol intake is widely recommended as a part of lifestyle modifications in the management of hypertension. 1-6 Alcohol has both pressor and depressor actions, however, and the genetic susceptibility regarding alcohol metabolism influences the cardiovascular effect of alcohol. 3,7 The effect of alcohol on blood pressure (BP) is also modified by several factors, such as the level of consumption, time period after the last drink and overall drinking behavior.Alcohol consumption is associated with several cardiovascular diseases, such as brain hemorrhage, heart failure and arrhythmia, as well as with other disorders. 3,[8][9][10][11] Heavy drinking and alcoholism not only lead to medical problems but are also serious social concerns. However, alcohol also seems to have beneficial effects, including the prevention of ischemic heart disease. It has been shown that cardiovascular and all-cause mortality is lower in light drinkers compared with nondrinkers. 3,[8][9][10][11][12] The purpose of this article is to review physio-pathological effects of alcohol on cardiovascular and related systems and to describe its role

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

Kawano

2010

Hypertens Res

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“…O elemento de maior significado no tratamento da cardiomiopatia alcoólica (CMA) é a abstinência, que deve ser perseguida em qualquer fase da agressão [3][4][5][6][8][9][10][11] . Alguns autores pregam a proibição total do consumo de álcool, não se admitindo sequer o seu uso social, pois deprime ainda mais o miocárdio, precipitando arritmias [8][9][10][11][12] .…”

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“…Alguns autores pregam a proibição total do consumo de álcool, não se admitindo sequer o seu uso social, pois deprime ainda mais o miocárdio, precipitando arritmias [8][9][10][11][12] . Recentemente, publicação do Serviço de Saúde Pública dos Estados Unidos da América aconselha desencorajar o seu consumo, sendo que naqueles onde for impossível alcançar a abstinência ou naqueles com pequeno grau de disfunção miocárdica, permitir o uso de dose única diária (<28g de etanol/dia) 13 .…”

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O significado da abstinência do álcool na cardiomiopatia alcoólica com disfunção ventricular moderada

Filho¹,

Castier²,

Boghossian³

et al. 1998

Arq. Bras. Cardiol.

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80g etanol/dia), por período de 51 a 112 (x=85) meses, que concordaram, inicialmente, em participar de programa de apoio, com psicoterapia de grupo, além do acompanhamento clínico com realização de exames não invasivos, antes do início do programa e após 12 meses da terapia, e foram divididos em dois grupos, o 1 (G-I) constituído pelos que atingiram a abstinência e o 2 (G-II) pelos não abstêmios. RESULTADOS: Após 12 meses, 11 (55%) pacientes permaneciam em terapia de apoio, 8 (72,72%) no G-I, enquanto os 9 (45%) que não se mantiveram no programa, apenas 2 (22,22%) tinham logrado abstinência (G-I). Ao fim da avaliação, alcançamos número igual de pacientes entre os grupos. Comparando os grupos observamos: a) menores valores médios dos diâmetros sistólico (DSVE) e diastólico (DDVE) do ventrículo esquerdo no G-I; b) maior número de internações no G-II (3) em relação ao G-I (1); c) na evolução clínica, maior número de pacientes do G-I, entre os que apresentaram melhoras (3 G-I e 1 G-II) e que permaneceram inalterados (6 G-I e 3 G-II), além do maior número de pioras entre o G-II (1 G-I e 5 G-II). CONCLUSÃO: Apesar do desejo inicial favorável, a abstinência só foi obtida em 50% dos pacientes com CMA e disfunção ventricular moderada, porém, quando alcançada, apresentou melhor evolução (melhoras + inalterados = 90%), com maior redução do DSVE e do DDVE (p<0,001), devendo sempre ser perseguida mesmo na presença de moderada disfunção ventricular.]]>

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Modifiable Risk Factors for Incident Heart Failure in the Coronary Artery Surgery Study

Hoffman¹

1994

Arch Intern Med

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Alcohol and the Cardiovascular System

Cited by 140 publications

References 54 publications

Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

Physio-pathological effects of alcohol on the cardiovascular system: its role in hypertension and cardiovascular disease

O significado da abstinência do álcool na cardiomiopatia alcoólica com disfunção ventricular moderada

Modifiable Risk Factors for Incident Heart Failure in the Coronary Artery Surgery Study

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