Alcohol and the heart: the good, the bad and the worse in heart failure

Rohde, Luís Eduardo Paim; Beck-da-Silva, Luís

doi:10.1136/heartjnl-2017-312924

Cited by 10 publications

(8 citation statements)

References 7 publications

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“…[ 57 ] Alcohol intake poses yet another modifiable risk factor in preventing the continued inflammatory processes associated with HF exacerbations. [ 58 ] Alcoholic cardiomyopathy has been noted as a deterrent for promoting cardioprotective effects of alcohol, and HF patients are cautioned against habitual drinking. [ 11 , 58 ] B/As were noted in particular to have increased heart disease, coronary artery disease in specific, if moderate drinking was a part of their lifestyle.…”

Section: Discussionmentioning

confidence: 99%

Heart failure symptom burden, dietary intake, and inflammation

DAVIS,

DUNBAR,

HIGGINS

et al. 2023

Journal of Integrative Nursing

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Heart failure (HF) is characterized by high symptom burden including, but not limited to fatigue, dyspnea, and edema. Up to 21.5% of HF patients experience significant depressive symptoms, much higher than 7.1% in adults without HF. Diet, metabolites, and other inflammatory mechanisms have gained notable attention in recent studies for contributions to symptoms in HF. Symptoms for black adults (B/As) with HF are often influenced by lifestyle factors, which may influence their higher mortality rates; few studies address these factors. Distinguishing the links between key elements with diet, inflammation, and symptoms may bring clarity for new dietary strategies in HF clinical care. The purpose of this integrative review is to examine the existing literature regarding relationships among physiologic pathways in HF along with physical and emotional symptoms in the context of inflammation, dietary intake, tumor necrosis factor-alpha (TNF-α), a biomarker of inflammation, and trimethylamine-N-Oxide (TMAO). Based on available evidence, inflammation may be a key link between physical symptoms, diet, depression, TMAO, and TNF-α in persons with HF and warrants further examination to clarify pathological links to solidify evidence for better guidance with dietary modifications. The literature reviewed in this study demonstrates that more work is needed to examine dietary planning, social support, and differences between men and women in the B/A community. Results of this literature review call attention to the essential, personalized care needs related to symptom monitoring and dietary planning which is expected to decrease symptom burden in the HF population.

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Section: Discussionmentioning

confidence: 99%

Heart failure symptom burden, dietary intake, and inflammation

DAVIS,

DUNBAR,

HIGGINS

et al. 2023

Journal of Integrative Nursing

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“…(33) Ambas moléculas tienen un impacto directo sobre la síntesis de proteínas en los miocitos y la peroxidación lipídica, reducen la contractilidad de las miofibrillas y aumentan el estrés oxidativo. (33,39) En estudios de resonancia magnética, Liu y colaboradores observaron valores T1 nativos más cortos y mayor volumen extracelular en el miocardio (similarmente a imágenes observadas en amiloidosis y sarcoidosis cardíacas) de un grupo de pacientes que consumía >28 gramos de etanol por día, durante un mínimo de 10 años, en comparación con un grupo control (incluyendo personas que tomaban <100 gramos de alcohol por mes). Cambios similares se perciben en resonancia magnética cuando se eleva el contenido de moléculas de grasa en la célula.…”

Section: Miocardiopatía Dilatadaunclassified

Efecto del alcohol sobre el corazón y el sistema cardiovascular: hipertrofia, remodelamiento y disminución del strain. Información actual

Hamala

Wierzbowska−Drabik²

2023

Rev Argent Cardiol

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Datos recientes muestran que el abuso crónico de alcohol puede conducir a disfunción cardiovascular, a partir de dosis de etanol tradicionalmente consideradas bajas, ya que la aparición de arritmias, incluyendo la fibrilación auricular, aumenta aún en consumidores de alcohol moderados.Los otros mecanismos comunes del impacto negativo del etanol están relacionados con el desarrollo de hipertensión y su consecuencia directa, la hipertrofia, fibrosis y disfunción diastólica.Debido a que la probabilidad de reversibilidad del remodelamiento cardíaco depende de un diagnóstico temprano de disfunción cardíaca, se debería recomendar la aplicación más amplia de métodos nuevos y más sensibles de evaluación de la función miocárdica, incluyendo el strain longitudinal ventricular izquierdo y derecho, así como de los protocolos adaptados a la ecocardiografía de estrés.

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“…Beyboun et al demonstrated that a reduction in physical activity is a risk factor for Alzheimer's disease and that 31.9% of these individuals developed dementia [65]. In addition, a clinical study found that, in individuals with overt depression, exercise resulted in reduced symptoms [66].…”

Section: Environmental and Nutritional "Stressors" And Oligodendrocytmentioning

confidence: 99%

Environmental and Nutritional “Stressors” and Oligodendrocyte Dysfunction: Role of Mitochondrial and Endoplasmatic Reticulum Impairment

et al. 2020

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Oligodendrocytes are myelinating cells of the central nervous system which are generated by progenitor oligodendrocytes as a result of maturation processes. The main function of mature oligodendrocytes is to produce myelin, a lipid-rich multi-lamellar membrane that wraps tightly around neuronal axons, insulating them and facilitating nerve conduction through saltatory propagation. The myelination process requires the consumption a large amount of energy and a high metabolic turnover. Mitochondria are essential organelles which regulate many cellular functions, including energy production through oxidative phosphorylation. Any mitochondrial dysfunction impacts cellular metabolism and negatively affects the health of the organism. If the functioning of the mitochondria is unbalanced, the myelination process is impaired. When myelination has finished, oligodendrocyte will have synthesized about 40% of the total lipids present in the brain. Since lipid synthesis occurs in the cellular endoplasmic reticulum, the dysfunction of this organelle can lead to partial or deficient myelination, triggering numerous neurodegenerative diseases. In this review, the induced malfunction of oligodendrocytes by harmful exogenous stimuli has been outlined. In particular, the effects of alcohol consumption and heavy metal intake are discussed. Furthermore, the response of the oligodendrocyte to excessive mitochondrial oxidative stress and to the altered regulation of the functioning of the endoplasmic reticulum will be explored.

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Alcohol and the heart: the good, the bad and the worse in heart failure

Cited by 10 publications

References 7 publications

Heart failure symptom burden, dietary intake, and inflammation

Heart failure symptom burden, dietary intake, and inflammation

Efecto del alcohol sobre el corazón y el sistema cardiovascular: hipertrofia, remodelamiento y disminución del strain. Información actual

Environmental and Nutritional “Stressors” and Oligodendrocyte Dysfunction: Role of Mitochondrial and Endoplasmatic Reticulum Impairment

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