Alcohol and the liver

Chaudhary, Sardar; Forrest, Ewan

doi:10.1016/j.mpmed.2019.08.009

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Excessive alcohol consumption causes histopathological changes and disfunction in the liver [ 2 ]. The elevation of hepatic enzymes in the serum indicates the occurrence of liver injury, such as AST, ALT, and LDH [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatoprotective Mechanism of Ginsenoside Rg1 against Alcoholic Liver Damage Based on Gut Microbiota and Network Pharmacology

Xia

Fang

Kang

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Alcoholic liver disease (ALD) is a major public health problem worldwide, which needs to be effective prevention. Ginsenoside Rg1 (GRg1), a bioactive ingredient extracted from ginseng, has benefit effects on health. In this study, 11 potential targets of GRg1 against ALD were firstly obtained by network pharmacology. KEGG pathway enrichment showed that GRg1-target-ALD was closely related to Toll-like receptor (TLR) and nuclear factor-kappa B (NF-κB) signaling pathways. In addition, GRg1 decreased antioxidant levels and increased oxidative levels in alcohol-treated mice, which alleviated oxidative stress-induced hepatic damage. GRg1 enhanced intestinal barrier function via upregulating the levels of tight junction protein and immunoglobulin A. GRg1 also reduced alcohol-induced inflammation by suppressing TLR4/NF-κB pathway, which was consistent with the prediction of network targets. Moreover, GRg1 altered GM population, and Verrucomicrobia, Bacteroidetes, Akkermansia, Bacteroides, Lachnospiraceae_NK4A136_group, and Alloprevotella played positive association with intestinal barrier indicators and negative correlation with hepatic inflammation biomarkers. The results suggest that GRg1 administration might be a promising strategy for protection of alcohol-induced liver damage.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Alcoholic liver disease (ALD) is an ubiquitous health burden around the world, which causes progression of liver damage [ 1 , 2 ]. It has been demonstrated that oxidative stress is a major pathogenesis of alcohol-induced liver damage, which is closely related to the development of ALD [ 3 ].…”

Section: Introductionmentioning

confidence: 99%