Alcohol and tobacco, and the risk of cancers of the upper aerodigestive tract in Latin America: a case–control study

Szymańska, Katarzyna; Hung, Rayjean J.; Wünsch-Filho, Victor; Eluf-Neto, José; Curado, María Paula; Koifman, Sérgio; Matos, Elena; Menezes, Ana; Fernández, Leticia; Daudt, Alexander W.; Boffetta, Paolo; Brennan, Paul

doi:10.1007/s10552-011-9779-7

Cited by 56 publications

(50 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Actions to prevent sunlight-related squamous cell carcinoma of the lip are as important as those directed towards tobacco and alcohol consumption, which increase the risk of oral squamous cell carcinoma by 5.49 and 4.62 times, respectively. 16 The percentage of malignant lesions (9.4%) found by the present study was similar to those found by other studies conducted in the Brazilian Northeast. 17 An exception was the predominance of lip cancer (57.1%) over intraoral cancer, which was most likely due to the large number of study participants who were exposed daily to ultraviolet radiation.…”

Section: Discussionsupporting

confidence: 92%

Oral cancer from a health promotion perspective: experience of a diagnosis network in Ceará

et al. 2014

View full text Add to dashboard Cite

The aim of this study is to share the experience of implementing a network for the diagnosis of oral cancer by integrating primary, secondary, and tertiary oral health care centers and identifying the possible weaknesses of the process. The study also investigated the risks of exposure to the main risk factors for oral and lip cancer and their most common potentially malignant lesions (PML). A quantitative cross-sectional study was conducted in two different regions, with patients seen at a primary health care facility from August 2010 to July 2011. Patients with oral lesions were referred to dental specialty centers for biopsy. Patients with PML were treated in dental specialty centers, and patients with squamous cell carcinoma (SCC) were referred to tertiary health care facilities. The dentists' knowledge of PML and SCC was assessed by an objective questionnaire. A total of 3,965 individuals were examined, 296 lesions were found, and 73 biopsies were performed, of which 13.7% were diagnosed as PML and 9.6% as SCC. Tobacco use and sunlight exposure were associated with SCC (85.7%) and PML (80%), respectively. In total, 55 dentists were assessed. The lesions most commonly recognized as PML were leukoplakia (74%), erythroplakia (57%), and actinic cheilosis (56%). Most dentists (74%) felt incapable of performing biopsies, most likely because of an anxiety towards oral cancer, and 57% had never performed one. The integration of primary and secondary health care enables the diagnosis of PML and SCC and establishes a diagnosis network. However, the inability of most primary care dentists to identify PML and perform biopsies is a weakness of the diagnostic process.

show abstract

Section: Discussionsupporting

confidence: 92%

Oral cancer from a health promotion perspective: experience of a diagnosis network in Ceará

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The etiologic factors strongly associated with the development of OSCC are the consumption of tobacco and alcohol (3,4). However, in recent decades, there has been an increasing trend of OSCC development in females and young adults, for whom other etiological factors like genetic heritage, dietary habits and Human Papilomavirus (HPV) infection have been pointed out as causes (5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Demographic and Clinical Profile of Oral Squamous Cell Carcinoma from a Service-Based Population

et al. 2017

View full text Add to dashboard Cite

The aim of this study was to evaluate the demographic and clinical profile of the oral squamous cells carcinoma (OSCC) cases registered in a center of oral diagnosis in southern Brazil. Eight hundred and six individuals with OSCC from 1959 to 2012 were included in this study. The variables recorded were: sex, age, occupation according to workplace, alcohol and tobacco consumption, skin color, tumor location, histological type, clinical appearance, size, evolution time, presence of pain and lymph node metastasis. Descriptive analysis was performed and the associations between variables were assessed using the chi-square and Fisher's exact test, with a confidence level of 5%. OSSC was more common in males (76.6%) aged between 51 to 70 years (53.9%). The most frequent sites were lower lip vermilion (23.3%), tongue (20.2%) and gingiva/alveolar ridge (18.1%). There was a strong association between outdoor occupation and white skin color with lip squamous cell carcinoma (LSCC). OSCC intraoral lesions were commonly more painful, larger than 2 cm and presented lymphatic metastasis. In conclusion, most of the results confirm the data from literature about sex, age, tumor location and occupation. Moreover, the positive correlations between LSCC and occupation, between LSCC and white skin color, and between bigger lesions and presence of pain/cervical metastasis also corroborate the literature data.

show abstract

“…Although alcoholic consumption is often cited as a known risk factor of oral cavity cancer (Altieri et al, 2004;Scully, 2011;Szymańska et al, 2011), some studies did find alcohol was not associated with an elevated risk of oral cavity cancer (Takács et al, 2011;Yen et al, 2008). One possible explanation for the seeming contradiction may be that different studies defined alcohol consumption differently.…”

Section: Alcohol Consumptionmentioning

confidence: 99%

“…Many studies have found that there is a synergic effect of cigarette smoking, alcoholic consumption, and betel quid chewing in carcinogenesis of oral cavity mucosa (Castellsagué et al, 2004;Chang et al, 2001;Ko et al, 1995;Szymańska et al, 2011;Wen et al, 2010;Yen et al, 2008). Patients who smoked and also consumed alcohol had an odds ratio of 9.03 for contracting oral cavity cancers, whereas patients who only smoke or only consumed alcohol had odds ratios of 4.65 and 0.95, respectively when compared with abstainers (Yen et al, 2008).…”

Section: Synergistic Effectmentioning

confidence: 99%

A Literature Analysis of the Risk Factors for Oral Cancer

Liu¹

2012

Oral Cancer

View full text Add to dashboard Cite

Alcohol and tobacco, and the risk of cancers of the upper aerodigestive tract in Latin America: a case–control study

Abstract: In this largest study on UADT cancer in Latin America, we have shown for the first time that a prevailing majority of UADT cancer cases is due to a combined effect of alcohol and tobacco use and could be prevented by quitting the use of either of these two agents.

Cited by 56 publications

References 17 publications

Oral cancer from a health promotion perspective: experience of a diagnosis network in Ceará

Oral cancer from a health promotion perspective: experience of a diagnosis network in Ceará

Demographic and Clinical Profile of Oral Squamous Cell Carcinoma from a Service-Based Population

A Literature Analysis of the Risk Factors for Oral Cancer

Contact Info

Product

Resources

About