Alcohol, Cigarette, and Cannabis Use Between 2002 and 2016 in Pregnant Women From a Nationally Representative Sample

Agrawal, Arpana; Rogers, Cynthia; Lessov‐Schlaggar, Christina N.; Carter, Ebony B.; Lenze, Shannon N.; Grucza, Richard A.

doi:10.1001/jamapediatrics.2018.3096

Cited by 75 publications

(47 citation statements)

References 4 publications

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“…It is not our view that cannabinoids are the only cause of ASD, as we feel that cannabinoids are but one cause amongst many. However since it seems clear that cannabinoids are likely to be an important cause of ASD, and since cannabinoid use has been shown to be increasing significantly across USA in recent years including by pregnant women [83,84] it would appear that at the very least the "cannabinoid-autism link" identified in this work is a potential major driver of the rise in autism rates across the country.…”

Section: Discussionmentioning

confidence: 79%

Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA

Reece

Hulse

2019

Clin Pediatr

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Section: Discussionmentioning

confidence: 79%

Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA

Reece

Hulse

2019

Clin Pediatr

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“…The lack of association with alcohol or tobacco use subsequent to knowledge of pregnancy may indicate the more pronounced public awareness of fetal risks and obstetric oversight of the use of these substances that leads to greater reductions in use post-knowledge of pregnancy, relative to cannabis. 8,64 Alternatively, prenatal cannabis exposure may serve as a proxy for exposure to a permissive home environment that promotes externalizing behaviors and related cognitive disengagement. 65 In addition, factors broadly correlated with prenatal substance use, such as restricted access to health care, birth-related complications and postpartum maternal behaviors, may plausibly contribute to these associations.…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, the alarming increase of cannabis use among pregnant mothers, 2,[6][7][8] and evidence linking prenatal exposure to adverse outcomes in children [9][10][11][12][13] prompted the Surgeon General of the United States to release an advisory against cannabis use during pregnancy and breastfeeding on August 29 th 2019. 14 Despite the increasing prevalence of prenatal cannabis exposure, there have been relatively few investigations of its association with child outcomes.…”

Section: Introductionmentioning

confidence: 99%

Prenatal cannabis exposure and childhood outcomes: Results from the ABCD study

Paul¹,

Hatoum²,

Fine³

et al. 2019

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Importance: In light of increasing cannabis use among pregnant women, the Surgeon General of the United States issued an advisory against the use of marijuana during pregnancy on August 29th, 2019. Objective: To determine whether cannabis use during pregnancy is associated with adverse outcomes among offspring. Design: Cross-sectional analysis of the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development (ABCD) study. Setting: Data were collected from 22 sites across the United States between 2016 and 2018. Participants: Children ages 9-11 (n=11,489) and their parent or caregiver. Exposure: Prenatal marijuana exposure prior to and following maternal knowledge of pregnancy. Main Outcomes and Measures: Child psychopathology symptomatology (i.e., psychotic-like experiences and internalizing, externalizing, attention, thought, and social problems), cognition, sleep, birth weight, gestational age at birth, body mass index (BMI), and brain structure (i.e., total intracranial volume, white matter volume, gray matter volume). Covariates included familial (e.g., income, familial psychopathology), pregnancy (e.g., prenatal vitamin use, whether the pregnancy was planned), and child (e.g., birth weight, substance use) variables. Results: Among 11,489 children (age 9.9±0.6 years; 47.78% female), 655 (5.70%) were prenatally exposed to cannabis in total. Marijuana use prior to (n=648; 5.64%) and following (n=242; 2.11%) maternal knowledge of pregnancy were associated with increased offspring psychopathology characteristics (i.e., psychotic-like experiences and internalizing, externalizing, attention, thought, social, and sleep problems) and BMI as well as reduced cognition, birth weight, and brain structure (i.e., total white and gray mater volumes; all psfdr<.007), but not gestational age at birth. Exposure following maternal knowledge of pregnancy remained significantly associated with psychopathology, cognition, and birth weight outcomes when including potentially confounding variables (all ps<0.046). All associations with exposure prior to maternal knowledge of pregnancy were nonsignificant when considering potentially confounding variables (all ps>0.06). Conclusions and Relevance: Prenatal cannabis exposure, and its correlated factors, may increase risk for psychopathology and reduced cognition during middle childhood as well as reduced birthweight. Consistent with recent recommendations by the Surgeon General, marijuana use during pregnancy should be discouraged.

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“…Prenatal cannabis use is increasing, 1,2 and several qualitative studies 3,4 indicate that pregnant women self-report using cannabis to manage stress and mood. However, few epidemiological studies have examined whether pregnant women with mental health disorders and trauma are at increased risk of using cannabis during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Association of Depression, Anxiety, and Trauma With Cannabis Use During Pregnancy

et al. 2020

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Alcohol, Cigarette, and Cannabis Use Between 2002 and 2016 in Pregnant Women From a Nationally Representative Sample

Abstract: during pregnancy have generally decreased. [3][4][5] These reports encourage more detailed characterization of patterns of substance use during the course of pregnancy.

Cited by 75 publications

References 4 publications

Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA

Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA

Prenatal cannabis exposure and childhood outcomes: Results from the ABCD study

Association of Depression, Anxiety, and Trauma With Cannabis Use During Pregnancy

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