Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies

Cheng, J Y W; Ng, E M L; Chen, R Y L; Ko, Jennifer S.

doi:10.1038/sj.ijir.3901556

Cited by 100 publications

(62 citation statements)

References 26 publications

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“…42,43 Excessive alcohol increases premature ejaculation, but studies clearly documenting increased ED are lacking. 41,44 Antioxidants Polyphenols are potent antioxidants found in high amounts in certain foods. Pomegranate has been shown to increase endothelial NO and prevent its breakdown.…”

Section: Excessive Alcoholmentioning

confidence: 99%

Lifestyle and metabolic approaches to maximizing erectile and vascular health

et al. 2011

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Oxidative stress and inflammation, which disrupt nitric oxide (NO) production directly or by causing resistance to insulin, are central determinants of vascular diseases including ED. Decreased vascular NO has been linked to abdominal obesity, smoking and high intakes of fat and sugar, which all cause oxidative stress. Men with ED have decreased vascular NO and circulating and cellular antioxidants. Oxidative stress and inflammatory markers are increased in men with ED, and all increase with age. Exercise increases vascular NO, and more frequent erections are correlated with decreased ED, both in part due to stimulation of endothelial NO production by shear stress. Exercise and weight loss increase insulin sensitivity and endothelial NO production. Potent antioxidants or high doses of weaker antioxidants increase vascular NO and improve vascular and erectile function. Antioxidants may be particularly important in men with ED who smoke, are obese or have diabetes. Omega-3 fatty acids reduce inflammatory markers, decrease cardiac death and increase endothelial NO production, and are therefore critical for men with ED who are under age 60 years, and/or have diabetes, hypertension or coronary artery disease, who are at increased risk of serious or even fatal cardiac events. Phosphodiesterase inhibitors have recently been shown to improve antioxidant status and NO production and allow more frequent and sustained penile exercise. Some angiotensin II receptor blockers decrease oxidative stress and improve vascular and erectile function and are therefore preferred choices for lowering blood pressure in men with ED. Lifestyle modifications, including physical and penile-specific exercise, weight loss, omega-3 and folic acid supplements, reduced intakes of fat and sugar, and improved antioxidant status through diet and/or supplements should be integrated into any comprehensive approach to maximizing erectile function, resulting in greater overall success and patient satisfaction, as well as improved vascular health and longevity.

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Section: Excessive Alcoholmentioning

confidence: 99%

Lifestyle and metabolic approaches to maximizing erectile and vascular health

et al. 2011

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“…At low levels, alcohol can reduce inhibition and increase sexual desire (Cheng et al 2007); however, beyond the level of the guidelines, the depressive effects of alcohol are apparent (Bacon et al 2003;Arackal & Benegal 2007). In females who consume alcohol heavily, the likelihood of heavy or irregular menstrual periods, spontaneous abortion and infertility is greater when alcohol is consumed above the guideline levels (Bradley et al 1998).…”

Section: Sexual Dysfunction -mentioning

confidence: 99%

Survey of alcohol-related presentations to Australasian emergency departments

et al. 2014

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Objective: To determine the proportion of alcohol‐related presentations to emergency departments (EDs) in Australia and New Zealand, at a single time point on a weekend night shift. Design, setting and participants: A point prevalence survey of ED patients either waiting to be seen or currently being seen conducted at 02:00 local time on 14 December 2013 in 106 EDs in Australia and New Zealand. Main outcome measures: The number of ED presentations that were alcohol‐related, defined using World Health Organization ICD‐10 codes. Results: At the 106 hospitals (92 Australia, 14 New Zealand) that provided data, 395 (14.3%; 95% CI, 13.0%–15.6%) of 2766 patients in EDs at the study time were presenting for alcohol‐related reasons; 13.8% (95% CI, 12.5%–15.2%) in Australia and 17.9% (95% CI, 13.9%–22.8%) in New Zealand. The distribution was skewed left, with proportions ranging from 0 to 50% and a median of 12.5%. Nine Australian hospitals and one New Zealand hospital reported that more than a third of their ED patients had alcohol‐related presentations; the Northern Territory (38.1%) and Western Australia (21.1%) reported the highest proportions of alcohol‐related presentations. Conclusions: One in seven ED presentations in Australian and New Zealand at this 02:00 snapshot were alcohol‐related, with some EDs seeing more than one in three alcohol‐related presentations. This confirms that alcohol‐related presentations to EDs are currently underreported and makes a strong case for public health initiatives.

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“…Traditionally, Mamajuana in Dominican Republic and Mead in Ireland have been used as aphrodisiacs. Although increased sexual arousal may be experienced by many who consume alcohol, studies have concluded negative effects of alcohol on sexual performance (Cheng, Ng, Chen, & Ko, 2007;Chew, 2009). Alcohol is a nervous system depressant, which can slow normal brain function, act as an anesthetic, and decrease blood circulation, thereby decreasing sensation and inhibiting normal erectile function and vaginal secretions (Peugh & Belenko, 2001).…”

Section: Alcoholmentioning

confidence: 99%