Alcohol Consumption and Risk of Glioma: A Meta-Analysis of 19 Observational Studies

Qi, Zhenyu; Shao, Chuan; Yang, Chao; Wang, Zhong; Gao, Hui

doi:10.3390/nu6020504

Cited by 24 publications

(19 citation statements)

References 43 publications

(136 reference statements)

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“… 3 , 4 Currently, besides the genetic syndromes (neurofibromatosis type I, Li Fraumeni syndrome), knowledge concerning glioma etiology remains limited to high dose therapeutic ionizing radiation, which was considered to be only well-documented environmental risk factor for gliomas. 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Smoking and Glioma Risk

Shao

Zhao

et al. 2016

Medicine

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Section: Introductionmentioning

confidence: 99%

Smoking and Glioma Risk

Shao

Zhao

et al. 2016

Medicine

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“… 1 , 2 The development of glioma is clearly associated with ionizing radiation. 3 , 4 Putative association with other factors, including pesticide exposure, 5 alcohol consumption, 6 smoking, 7 obesity, 8 and sex hormones, 9 has also been noted. Cigarette smoking is the most important modifiable cause of many types of human cancers, including the respiratory, digestive, hematologic, and urinary systems.…”

Section: Introductionmentioning

confidence: 97%

Cigarette smoking and risk of adult glioma: a meta-analysis of 24 observational studies involving more than 2.3 million individuals

Peng

Zong

et al. 2016

OTT

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BackgroundCigarette smoking has been shown to be a risk factor for adult glioma by some but not all studies. We conducted a meta-analysis to systematically assess the potential association.MethodsPubMed and EMBASE were searched from the date of their inception to October 1, 2015, to identify relevant articles. Reference lists from these articles were reviewed to identify additional studies. Both cohort and case–control studies were included. Fixed-effects models were used to calculate the overall relative risk (RR) with corresponding 95% confidence intervals (CIs).ResultsThe final analysis included 24 studies (seven cohort and 17 case–control studies), involving more than 2.3 million individuals. The combined RR was 1.04 (95% CI: 1.00, 1.09; P=0.073) for ever-smokers, 0.97 (95% CI: 0.88, 1.07; P=0.574) for current-smokers, and 1.07 (95% CI: 0.98, 1.16; P=0.130) for past smokers, with little evidence of heterogeneity. Omission of any single study from the analysis had little effect on the result. No evidence of publication bias was found. A small but statistically significant increase was found in past smokers in females (RR: 1.13, 95% CI: 1.00, 1.28; P=0.046) but not in males.ConclusionIn general, there was no association between cigarette smoking and adult glioma. The small but statistically significant association in females requires further investigation.

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“…Nevertheless, the research results on the impact of alcohol consumption on glioma risk have not been conclusive. Qi et al [ 11 ] performed a meta-analysis of 19 observational studies (15 case-control and four cohort studies) to link the alcohol consumption with the risk of glioblastoma. There was no correlation found here as the combined RR was 0.96 (95% CI: 0.89–1.04).…”

Section: Resultsmentioning

confidence: 99%

The Influence of Nutritional and Lifestyle Factors on Glioma Incidence

Bielecka

Markiewicz‐Żukowska

2020

Nutrients

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Cancers are the first main cause of premature death in developed countries. Since brain tumors, especially gliomas, are the most lethal type of cancers, risk factors for their prevalence are still being discussed. Nearly 30–50% of all cancers could be prevented by proper nutritional habits and other lifestyle factors, but their influence on the tumors of the central nervous system has not been explained completely and still requires further studies. That is why we attempted to review the available research in this field, with a special focus on the factors with the proven protective activity observed in other cancers. Adequate vegetables and antioxidants (such as vitamins C and A) provided with a diet could have a protective effect, while other factors have shown no correlation with the incidence of glioma. However, further studies are necessary to determine whether fish, coffee, and tea consumption may prevent glioma. Maintaining proper body weight and undertaking a sufficient level of daily physical activity also seem to be important. Excessive body mass index (BMI) and higher attained height have increased the risk of glioma. In order to link more accurately the chosen factors to the prevalence of gliomas, it seems necessary to conduct large cohort, prospective, controlled studies in different world regions.

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Alcohol Consumption and Risk of Glioma: A Meta-Analysis of 19 Observational Studies

Cited by 24 publications

References 43 publications

Smoking and Glioma Risk

Smoking and Glioma Risk

Cigarette smoking and risk of adult glioma: a meta-analysis of 24 observational studies involving more than 2.3 million individuals

The Influence of Nutritional and Lifestyle Factors on Glioma Incidence

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