Alcohol consumption and risk of dementia: the Rotterdam Study

Ruitenberg, Annemieke; Swieten, John van; Witteman, Jacqueline C. M.; Mehta, Kala M.; Duijn, Cornelia M. van; Hofman, Albert; Breteler, Monique M.B.

doi:10.1016/s0140-6736(02)07493-7

Cited by 481 publications

(280 citation statements)

References 29 publications

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“…15,16 Although other mechanisms are likely to be involved, the relationship between alcohol intake and the level of inflammatory markers would offer an additional biologically plausible explanation. Indeed, recent epidemiological 5,6 and experimental 17 studies reported an association between moderate alcohol intake and lower levels of CRP in a sample of middle-aged men and women.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults

et al. 2004

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Background-Increased levels of acute-phase reactants predict the onset of poor health outcomes. A U-shaped association has been reported between alcohol intake and health outcomes, which suggests that alcohol intake may modify levels of acute-phase reactants. We investigated the relationship between weekly alcohol intake and interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-␣ (TNF-␣), and plasminogen activator inhibitor-1 (PAI-1). Methods and Results-Data are from year 1 of the Health, Aging, and Body Composition study, a biracial cohort of 3075 well-functioning men and women aged 70 to 79 years, living in Memphis, Tenn, and Pittsburgh, Pa. The analysis included 2574 persons (51.2% women; 40.1% black) with complete data. After adjustment for age, race, smoking status, history of diabetes, history of cardiovascular disease, physical activity, high-density lipoprotein cholesterol, antiinflammatory medications, statins, and total fat mass, alcohol intake showed a J-shaped relationship with mean IL-6 (P for quadratic term Ͻ0.001) and CRP (Pϭ0.014) levels. The association was consistent in both men and women. Compared with subjects who consumed 1 to 7 drinks per week, those who never drank had an increased likelihood of having high levels of both IL-6 and CRP, as did those who drank 8 or more drinks per week. We found no relationship between alcohol intake and levels of TNF-␣ and PAI-1 (Pϭ0.137 and 0.08, respectively). Conclusions-In well-functioning older persons, light alcohol consumption is associated with lower levels of IL-6 and CRP. These results might suggest an additional biological explanation to the epidemiological link between moderate alcohol consumption and cardiovascular events.

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Section: Discussionmentioning

confidence: 99%

Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults

et al. 2004

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“…After first reports found no association [1,9,10,15], more recent results point to a protective effect of alcohol, mostly associated to moderate intakes and to wine consumption [16][17][18]. But differences according to type of alcohol beverage consumed have not always been observed [19]; and increased risks have also been reported for heavy alcohol consumption [20]. Analyses of interactions between alcohol consumption and ApoE4 alleles are scant and conflicting [18,19].…”

Section: Introductionmentioning

confidence: 99%

Isolated and Joint Effects of Tobacco and Alcohol Consumption on Risk of Alzheimer's Disease

García

Ramón-Bou

Porta

2010

JAD

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Abstract. The roles of smoking and alcohol on the development of Alzheimer's disease (AD) remain unclear. We performed a case-control study on the effects of both exposures before the age of onset of the disease in the cases (and same reference age for their age-matched controls) on disease risk. Interviews were conducted with population controls (n = 246) and relatives of cases (n = 176) identified through local Alzheimer's Disease Associations. Logistic regression models were built adjusting by gender, age, residence, education, economic situation, employment, and history of dementia in close relatives. Risk of AD was unaffected by any measure of tobacco consumption. Alcohol consumers showed a lower risk of AD than never consumers (adjusted odds ratio, aOR = 0.53, 95% CI 0.32, 0.88), with differences by gender (women aOR = 0.48, 95% CI 0.27, 0.84; men aOR = 0.80, 95% CI 0.23, 2.80). Mean daily total consumption of alcohol and time consuming alcohol showed increasingly protective dose-response relationships in women. Lower AD risk was observed in alcohol drinkers of both genders who never smoked (aOR = 0.37, 95% CI 0.21, 0.65). All these associations were independent of the presence of apolipoprotein E4 allele(s) in the cases. Although the sample was small for some analyses addressing these interactions, our results suggest a protective effect of alcohol consumption, mostly in non-smokers, and the need to consider interactions between tobacco and alcohol consumption, as well as interactions with gender, when assessing the effects of smoking and/or drinking on the risk of AD.

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“…The Rotterdam Study followed 5,395 subjects aged 55 years or older over a period of 6 years; 197 incidents cases of dementia were diagnosed (2). The number of drinks of alcohol (beer, wine, fortified wine, or spirits) was collected at baseline and five categories of intake were studied: no drinks consumed; less than 1 drink per week; more than 1 drink per week but less than 1 per day; 1 to 3 drinks per day; more than 3 drinks per day.…”

mentioning

confidence: 99%

Moderate Alcohol Consumption and Risk of Developing Dementia in the Elderly: The Contribution of Prospective Studies

Letenneur

2007

Annals of Epidemiology

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Alcohol consumption and risk of dementia: the Rotterdam Study

Cited by 481 publications

References 29 publications

Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults

Relationship of Alcohol Intake With Inflammatory Markers and Plasminogen Activator Inhibitior-1 in Well-Functioning Older Adults

Isolated and Joint Effects of Tobacco and Alcohol Consumption on Risk of Alzheimer's Disease

Moderate Alcohol Consumption and Risk of Developing Dementia in the Elderly: The Contribution of Prospective Studies

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