Alcohol consumption and socioeconomic status associated with the risk of kidney cancer in a large Australian cohort study

Kim, Lawrence H.; Bang, Albert; Sarich, Peter; Nair-Shalliker, Visalini; Patel, Manish I.; Smith, David P.

doi:10.1016/j.annepidem.2023.04.014

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…There is limited epidemiological evidence of a relationship between alcohol consumption and the risk of renal cancer and benign prostatic hyperplasia [3,[60][61][62]. However, contrasting research has pinpointed both smoking and alcohol consumption as significant contributors to renal cancer risk [63].…”

Section: Discussionmentioning

confidence: 99%

Alcohol Exposure and Disease Associations: A Mendelian Randomization and Meta-Analysis on Weekly Consumption and Problematic Drinking

Li,

Zhang,

Chen

et al. 2024

Nutrients

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Alcohol consumption significantly impacts disease burden and has been linked to various diseases in observational studies. However, comprehensive meta-analyses using Mendelian randomization (MR) to examine drinking patterns are limited. We aimed to evaluate the health risks of alcohol use by integrating findings from MR studies. A thorough search was conducted for MR studies focused on alcohol exposure. We utilized two sets of instrumental variables—alcohol consumption and problematic alcohol use—and summary statistics from the FinnGen consortium R9 release to perform de novo MR analyses. Our meta-analysis encompassed 64 published and 151 de novo MR analyses across 76 distinct primary outcomes. Results show that a genetic predisposition to alcohol consumption, independent of smoking, significantly correlates with a decreased risk of Parkinson’s disease, prostate hyperplasia, and rheumatoid arthritis. It was also associated with an increased risk of chronic pancreatitis, colorectal cancer, and head and neck cancers. Additionally, a genetic predisposition to problematic alcohol use is strongly associated with increased risks of alcoholic liver disease, cirrhosis, both acute and chronic pancreatitis, and pneumonia. Evidence from our MR study supports the notion that alcohol consumption and problematic alcohol use are causally associated with a range of diseases, predominantly by increasing the risk.

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Section: Discussionmentioning

confidence: 99%

Alcohol Exposure and Disease Associations: A Mendelian Randomization and Meta-Analysis on Weekly Consumption and Problematic Drinking

Li,

Zhang,

Chen

et al. 2024

Nutrients

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“…The environmental risk factors mentioned above may independently or through a synergistic interaction increase the risk of KC incidence and mortality. Previous studies have considered the role of socioeconomic status on the KC burden and variation in KC risk factors 9 – 11 .…”

Section: Introductionmentioning

confidence: 99%

Decomposing difference in the kidney cancer burden measures between 1990 and 2019 based on the global burden of disease study

Ayubi,

Shahbazi,

Khazaei

2024

Sci Rep

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The kidney cancer (KC) burden measures have changed dramatically in recent years due to changes in exposure to the determinants over time. We aimed to decompose the difference in the KC burden measures between 1990 and 2019. This ecological study included data on the KC burden measures as well as socio-demographic index (SDI), behavioral, dietary, and metabolic risk factors from the global burden of disease study. Non-linear multivariate decomposition analysis was applied to decompose the difference in the burden of KC. Globally, ASIR, ASMR, and ASDR of KC increased from 2.88 to 4.37, from 1.70 to 2.16, and from 46.13 to 54.96 per 100,000 people between 1990 and 2019, respectively. The global burden of KC was more concentrated in developed countries. From 1990 to 2019, the burden of KC has increased the most in Eastern European countries. More than 70% of the difference in the KC burden measures between 1990 and 2019 was due to changes in exposure to the risk factors over time. The SDI, high body mass index (BMI), and alcohol use had the greatest contribution to the difference in the KC burden measures. Changes in characteristics over time, including SDI, high BMI, and alcohol consumption, appear to be important in the evolving landscape of KC worldwide. This finding may help policymakers design policies and implement prevention programs to control and manage KC.

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“…Many studies have shown that smoking is a risk factor for kidney cancer, while alcohol consumption has a protective effect against the occurrence of kidney cancer. ( Capitanio et al, 2019 ; Bukavina et al, 2022 ; Kim et al, 2023 ). However, the nature of the relationship between smoking, drinking, and the risk of RCC remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

The causal relationship between smoking, alcohol consumption, and renal clear cell carcinoma: a Mendelian randomization study

Cui,

Du,

Xue

et al. 2024

Front. Genet.

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Introduction: Observational studies have found a correlation between the consumption of tobacco and alcohol and the likelihood of developing renal cell carcinoma. However, whether these associations indicate causal relationships is unclear.Methods: To establish if these connections indicate causal relationships, we performed a Mendelian Randomization (MR) analysis using a two-sample approach. For the number of daily cigarettes, lifetime smoking index, smoking initiation, and weekly drinking, we employed 44, 108, 174, and 76 single nucleotide polymorphisms (SNPs) as instrumental variables. Outcome data were obtained from the FinnGen Alliance, which included a combined total of 429,290 individuals. The MR analysis was conducted using the inverse-variance weighted (IVW) method to estimate causal effects. To address potential violations of MR assumptions due to directional pleiotropy, we performed MR-Egger regression and MR-PRESSO (Mendelian Randomization Pleiotropy RESidual Sum and Outlier) analysis.Results: Genetically influenced smoking initiation was directly associated with the risk of developing renal cell carcinoma (OR = 1.55, 95% CI: 1.04–2.33; p = 0.03). No causal relationship was found between daily cigarette consumption and lifetime smoking index with the risk of renal cell cancer. Genetic predisposition for weekly alcohol consumption showed a reduced risk of renal cell cancer (OR = 0.45, 95% CI: 0.26–0.81; p = 0.007).Discussion: Our study suggests a potential causal relationship between alcohol consumption and reduced risk of renal cell cancer, while no such association was observed with smoking. Further research is needed to confirm these findings.

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Alcohol consumption and socioeconomic status associated with the risk of kidney cancer in a large Australian cohort study

Cited by 5 publications

References 43 publications

Alcohol Exposure and Disease Associations: A Mendelian Randomization and Meta-Analysis on Weekly Consumption and Problematic Drinking

Alcohol Exposure and Disease Associations: A Mendelian Randomization and Meta-Analysis on Weekly Consumption and Problematic Drinking

Decomposing difference in the kidney cancer burden measures between 1990 and 2019 based on the global burden of disease study

The causal relationship between smoking, alcohol consumption, and renal clear cell carcinoma: a Mendelian randomization study

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