Alcohol Consumption and the Risk for Developing Pancreatitis

Kaneda, Kiyoshi; Masamune, Atsushi; Ariga, Hiroyuki; Shimosegawa, Tooru

doi:10.1097/mpa.0000000000000256

Cited by 35 publications

(16 citation statements)

References 26 publications

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“…Alcohol consumption is strongly associated with CP [18][19][20] . In our study, there were no significant differences in alcohol consumption between the groups with and without EUS-CP findings, but the presence of these findings was associated with pathological changes of the background parenchyma, such as atrophy and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Chronic Pancreatitis Finding by Endoscopic Ultrasonography in the Pancreatic Parenchyma of Intraductal Papillary Mucinous Neoplasms Is Associated with Invasive Intraductal Papillary Mucinous Carcinoma

Takenaka¹,

Masuda²,

Shiomi³

et al. 2017

Oncology

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Background/Objectives: The recent guideline for intraductal papillary mucinous neoplasms (IPMNs) focuses on morphological features of the lesion as signs of malignant transformation, but ignores the background pancreatic parenchyma, including features of chronic pancreatitis (CP), which is a risk factor for pancreatic malignancies. Endoscopic ultrasonography frequently reveals evidence of CP (EUS-CP findings) in the background pancreatic parenchyma of patients with IPMNs. Therefore, we investigated whether background EUS-CP findings were associated with malignant IPMN. Methods: The clinical data of 69 consecutive patients with IPMNs who underwent preoperative EUS and surgical resection between April 2010 and October 2014 were collected prospectively. The association of EUS-CP findings (total number of EUS-CP findings; 0 vs. ≥1) with invasive IPMN was examined. The association of EUS-CP findings with pathological changes of the background pancreatic parenchyma (atrophy/inflammation/fibrosis) was also examined. Results: Among patients with EUS-CP findings, invasive intraductal papillary mucinous carcinoma (IPMC) was significantly more frequent than among patients without EUS-CP findings (42.5% [17/40] vs. 3.4% [1/29], p = 0.0002). In addition, patients with EUS-CP findings had higher grades of pancreatic atrophy and inflammation than patients without EUS-CP findings (atrophy: 72.5% [29/40] vs. 34.5% [10/29], p = 0.003; inflammation: 45.0% [18/40] vs. 20.7% [6/29], p = 0.04). Conclusions: In IPMN patients, detection of EUS-CP findings in the background pancreatic parenchyma was associated with a higher prevalence of invasive IPMC. Accordingly, EUS examination should not only assess the morphological features of the lesion itself, but also EUS-CP findings in the background parenchyma.

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Section: Discussionmentioning

confidence: 99%

Chronic Pancreatitis Finding by Endoscopic Ultrasonography in the Pancreatic Parenchyma of Intraductal Papillary Mucinous Neoplasms Is Associated with Invasive Intraductal Papillary Mucinous Carcinoma

Takenaka¹,

Masuda²,

Shiomi³

et al. 2017

Oncology

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“…[22][23][24][25] Therefore, in most countries with high alcohol consumption levels, the prevalence and severity of alcoholic AP are likely underestimated.…”

Section: 2412mentioning

confidence: 99%

The Etiologic Evaluation of Acute Pancreatitis in a General Hospital of Seoul-Gyeonggi Province in Korea

Youn

Chung

Lee

et al. 2017

Korean J Gastroenterol

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Background/Aims: In recent years, the incidence of acute pancreatitis (AP) has been increasing. A better understanding of the etiology is directly linked to more favorable outcomes. Unfortunately, there have been reports suggesting the variation of etiologies of AP across countries. The objective of this study was to determine the etiology of AP in a general hospital of Seoul-Gyeonggi province in Korea during the past decade. Methods: We retrospectively reviewed the medical records of consecutive patients with AP who were admitted to St. Paul's Hospital (Seoul, Korea) with an affiliation to the Catholic University of Korea between January 2003 and January 2013. Results: A total of 1,110 patients were enrolled, totaling 1,833 attacks, and the most frequent cause of AP was alcohol consumption. The recurrence rate of AP was 24.5% (272/1,110), and habitual recurrence rate (more than three times) was 12.6% (140/1,110). The rate of severe AP was 4.9% (90/1,833 attacks). The mortality rate of AP was 2.6% (29/1,110 patients). The frequency of an idiopathic cause of AP was 13.3%. The recurrence rate and mortality rate of idiopathic AP were 16.2% and 5.4%, respectively. In 41.7% (10/24) of cases of idiopathic AP, microlithiasis was suspected. Conclusions: Between 2003 and 2013 in Korea, alcohol was the most frequent cause of AP in the general hospital of Seoul-Gyeonggi province of Korea. It appears that alcohol abstinence program may be necessary. Further nationwide studies would be needed to evaluate the etiologies of AP. (Korean J Gastroenterol 2017;70:190-197)

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“…The environmental factors that interact with these common variants and increase the risk of pancreatitis in patients with ICP are unknown. Possible candidate factors might include smaller amounts of alcohol and smoking 4. We have previously reported a nationwide case–control study in Japan showing that alcohol consumption of <80 g/day is associated with a risk of CP 4.…”

mentioning

confidence: 99%

“…Possible candidate factors might include smaller amounts of alcohol and smoking 4. We have previously reported a nationwide case–control study in Japan showing that alcohol consumption of <80 g/day is associated with a risk of CP 4. In cases with CP, ORs (95% CI) for alcohol consumption of ≥20 to <40, ≥40 to <60 and ≥60 to <80 g/day were 2.6 (1.2 to 5.5), 3.2 (1.5 to 7.1) and 9.2 (4.1 to 20.3), respectively 4.…”

mentioning

confidence: 99%

“…We have previously reported a nationwide case–control study in Japan showing that alcohol consumption of <80 g/day is associated with a risk of CP 4. In cases with CP, ORs (95% CI) for alcohol consumption of ≥20 to <40, ≥40 to <60 and ≥60 to <80 g/day were 2.6 (1.2 to 5.5), 3.2 (1.5 to 7.1) and 9.2 (4.1 to 20.3), respectively 4. Identification of such factors would contribute to further understanding of the pathobiology of CP and novel therapeutic approaches against this intractable disease.…”

mentioning

confidence: 99%

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Common variants atPRSS1–PRSS2andCLDN2–MORC4loci associate with chronic pancreatitis in Japan

Masamune

Nakano

Hamada

et al. 2015

Gut

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Alcohol Consumption and the Risk for Developing Pancreatitis

Abstract: Our study precisely measured the quantitative effect of alcohol on the risk for developing pancreatitis.

Cited by 35 publications

References 26 publications

Chronic Pancreatitis Finding by Endoscopic Ultrasonography in the Pancreatic Parenchyma of Intraductal Papillary Mucinous Neoplasms Is Associated with Invasive Intraductal Papillary Mucinous Carcinoma

Chronic Pancreatitis Finding by Endoscopic Ultrasonography in the Pancreatic Parenchyma of Intraductal Papillary Mucinous Neoplasms Is Associated with Invasive Intraductal Papillary Mucinous Carcinoma

The Etiologic Evaluation of Acute Pancreatitis in a General Hospital of Seoul-Gyeonggi Province in Korea

Common variants atPRSS1–PRSS2andCLDN2–MORC4loci associate with chronic pancreatitis in Japan

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