Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women’ Lifestyle and Health Study

Shin, Aesun; Sandin, Sven; Löf, Marie; Margolis, Karen L.; Kim, Kyeezu; Couto, Elisabeth; Adami, Hans Olov; Weiderpass, Elisabete

doi:10.1186/s12885-015-1896-3

Cited by 19 publications

(13 citation statements)

References 30 publications

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“…Epidemiological studies adjusting the association for overweight and obesity show that the correlation between alcohol consumption and BC is not statistically significant (RR 1.01) and the risk is only slightly increased in women with BMI ≤ 25 (RR 1.03) (ref. 25 ). After adjustment for the effects of age, BMI and smoking, a multivariate analysis of higher γ-glutamyltransferase levels found a slightly increased risk of BC compared to that in women having low levels (RR 1.21) (ref.…”

Section: Alcohol Consumptionmentioning

confidence: 99%

Risks and protective factors for triple negative breast cancer with a focus on micronutrients and infections

Horáková

Bouchalová

Cwiertka

et al. 2018

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out. We also found statistical information from current online databases concerning the estimated incidence, prevalence and mortality worldwide of this cancer. Traditional risk factors for BC and TNBC are those related to reproduction such as the age of menarche, age of first birth, parity, breastfeeding and age at menopause. Attention needs to be paid to familial BC, weight control, alcohol consumption and regular physical activity. Epidemiological studies on TNBC provide evidence for protective factors such as regular consumption of soya, seafood, green tea, folic acid and vitamin D. Potential risk factors may include night work and viral infectious agents like human papillomavirus (HPV) and Epstein-Barr virus (EBV). Droplet digital methylation-specific PCR (ddMSP) is a possible new screening method for detection of BC including TNBC. Further research is necessary to validate these new factors.

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Section: Alcohol Consumptionmentioning

confidence: 99%

Risks and protective factors for triple negative breast cancer with a focus on micronutrients and infections

Horáková

Bouchalová

Cwiertka

et al. 2018

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Potential confounders were selected based on a previous study [9]. Potential confounders were categorized as follows, as in previous publications describing this cohort [9,10]: body mass index (kg/m 2 ; < 25, 25-30, ≥ 30, or missing), education (years; ≤ 10, 11-13, or > 13), smoking history (never or ever), and alcohol intake (g/day; < 5, 5-25, ≥ 25). Due to the relatively high percentage of missing data, the intake frequency of meat (n=13,088) and sausage (n=19,030) were not considered in the multivariate analysis.…”

Section: Study Populationmentioning

confidence: 99%

Omega-3 and -6 Fatty Acid Intake and Colorectal Cancer Risk in Swedish Women’s Lifestyle and Health Cohort

et al. 2020

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Original ArticlePurpose We aimed to assess the association between the dietary intake of fish-derived omega-3 polyunsaturated fatty acids and the risk of colorectal cancer among Swedish women. Materials and MethodsA total of 48,233 women with information on dietary intake were included in the analysis. Participants were followed for incident colorectal cancer until 31 December 2012. Cox proportional hazard models were used to assess the association between baseline fatty acid intake and colorectal cancer risk. All analyses were stratified by colon and rectal cancers. ResultsDuring a median of 21.3 years of follow-up, a total of 344 colorectal cancer cases were ascertained. Although there was no overall association between omega-3 fatty acid intake and colorectal cancer risk, high intake of fish-derived docosahexaenoic acid was associated with reduced risk of rectal cancer (hazard ratios for the third and the highest quartiles were 0.59 (95% confidence interval [CI], 0.37 to 0.96) and 0.62 (95% CI, 0.39 to 0.98), respectively). ConclusionIn conclusion, we found only limited support for an association between omega-3 polyunsaturated fatty acids and colorectal cancer in a large Swedish cohort of middle-aged women.

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“…Shin i wsp. (29) przedstawili wyniki badania Women's Lifestyle and Health Study -oparte na analizie ponad 45 tys. kobiet, spośród których u 1385 w czasie 17 lat rozwinął się rak piersi.…”

Section: Rak Piersiunclassified

“…Alcohol consumption is associated with changed levels of sex hormones circulating in the system, which may increase the risk of hormone-dependent cancers (28) . Shin et al (29) presented the results of the Women's Lifestyle and Health Study, which was based on the analysis of over 45,000 women, 1,385 of whom developed breast cancer within 17 years. Higher alcohol consumption (>5 g a day, which corresponds to >2 glasses of wine a week) was associated with an increased risk of breast cancer among women with a BMI of ≤25, irrespective of receptor status.…”

Section: Breast Cancermentioning

confidence: 99%

Infl uence of recreational psychoactive substances on the development of gynecologic cancers

Markowska¹,

Kaysiewicz²,

Makówka³

et al. 2016

Curr. Gynecol. Oncol.

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Herbata i kawa-napoje bardzo często spożywane przez ludzi-zawierają flawonoidy, mające działanie antyoksydacyjne. Wykazano protekcyjny wpływ konsumpcji zielonej herbaty na rozwój zarówno stanów przedrakowych, jak i raka szyjki macicy. Picie czarnej herbaty wiąże się zaś ze spadkiem ryzyka wystąpienia raka jajnika i raka piersi u kobiet po menopauzie. Spożycie kawy obniża ryzyko rozwoju raka endometrium typu I. Większość badań wskazuje również na ochronne działanie kawy w odniesieniu do raka piersi u kobiet po menopauzie; jak się wydaje, zależy ono od stanu receptorów hormonalnych. Z kolei napoje alkoholowe, zaklasyfikowane jako karcynogeny klasy I, zawierają substancje o działaniu rakotwórczym, a w wyniku ich metabolizmu powstają szkodliwe wolne rodniki. Wykazano, że alkohol zwiększa ryzyko infekcji HPV, przyczynowo związanej z rozwojem stanów przedrakowych szyjki macicy, a także ryzyko nawrotu raka szyjki macicy. W przypadku raka endometrium uzyskiwano rozbieżne wyniki-wydaje się, że piwo i wino mogą obniżyć ryzyko, jednak inne napoje alkoholowe spożywane w większej ilości je zwiększają. Picie wina wiąże się ze spadkiem ryzyka rozwoju endometrioidalnego raka jajnika, ale nie innych typów histologicznych tego nowotworu; może to być związane z protekcyjnym działaniem resweratrolu. Wykazano, że różne rodzaje alkoholu są niekorzystne w kontekście rozwoju raka piersi. Słowa kluczowe: herbata, kawa, alkohol, rak szyjki macicy, rak endometrium, rak jajnika, rak piersi Tea and coffee, beverages most commonly consumed by people, contain flavonoids, which have an antioxidant effect. It has been proven that green tea consumption protects against both precancerous lesions and cervical cancer. Black tea consumption is associated with a reduced risk of ovarian and breast cancer development in postmenopausal women. Drinking coffee lowers the risk of type I endometrial cancer. The majority of studies on postmenopausal women with breast cancer show a protective role of coffee, which seems to be related to the state of hormonal receptors. Alcoholic beverages, on the other hand, are classified as class 1 carcinogens and their metabolism generates harmful free radicals. Alcohol is also associated with an increased risk of HPV infection, which is in turn causally responsible for the development of precancerous cervical lesions. In addition, alcohol increases the risk of recurrence of cervical cancer. In the case of endometrial cancer the views are rather divergent. Some studies suggest that beer and wine may reduce the risk of cancer, while other studies show that other alcoholic beverages consumed in greater quantities increase that risk.

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Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women’ Lifestyle and Health Study

Cited by 19 publications

References 30 publications

Risks and protective factors for triple negative breast cancer with a focus on micronutrients and infections

Risks and protective factors for triple negative breast cancer with a focus on micronutrients and infections

Omega-3 and -6 Fatty Acid Intake and Colorectal Cancer Risk in Swedish Women’s Lifestyle and Health Cohort

Infl uence of recreational psychoactive substances on the development of gynecologic cancers

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