Alcohol Consumption in Pregnant, Black Women Is Associated With Decreased Plasma and Erythrocyte Docosahexaenoic Acid

Stark, Ken D.; Beblo, Skadi; Murthy, M.R.V.; Whitty, Janice E.; Buda-Abela, Michelle; Janisse, James; Rockett, Helaine; Martier, Susan S.; Sokol, Robert J.; Hannigan, John H.; Salem, Norman

doi:10.1097/01.alc.0000150013.65416.06

Cited by 42 publications

(51 citation statements)

References 78 publications

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“…For instance, at low intakes of n-3 HUFA, blood biomarker status can be influenced by sex hormones. 38,[40][41][42] Stratification by sex did not significantly improve correlation coefficients (Fisher's Z-test, PϾ0.05), but these variables, in addition to effects like alcohol intake and smoking on fatty acid metabolism, 10,43 can lead to inter-individual variation in response to dietary EPA and DHA intake and could be taken into account when using the FFQ in larger studies. Additional considerations should be made when using the present FFQ to estimate EPA and DHA intakes.…”

Section: Researchmentioning

confidence: 96%

Biomarker and Dietary Validation of a Canadian Food Frequency Questionnaire to Measure Eicosapentaenoic and Docosahexaenoic Acid Intakes from Whole Food, Functional Food, and Nutraceutical Sources

Patterson¹,

Hogg²,

Kishi³

et al. 2012

Journal of the Academy of Nutrition and Dietetics

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Section: Researchmentioning

confidence: 96%

Biomarker and Dietary Validation of a Canadian Food Frequency Questionnaire to Measure Eicosapentaenoic and Docosahexaenoic Acid Intakes from Whole Food, Functional Food, and Nutraceutical Sources

Patterson¹,

Hogg²,

Kishi³

et al. 2012

Journal of the Academy of Nutrition and Dietetics

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“…Blood samples were obtained at Wayne State University in Detroit, MI as previously described [16]. The study was approved by the Wayne State University Human Investigations Committee and informed consent was obtained from all participants.…”

Section: Human Blood Samplesmentioning

confidence: 99%

The Percentage of n‐3 Highly Unsaturated Fatty Acids in Total HUFA as a Biomarker for Omega‐3 Fatty Acid Status in Tissues

Stark¹

2007

Lipids

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A blood biomarker of omega-3 fatty acid intake and tissue status could serve as a modifiable risk factor for cardiovascular disease. The percentage of omega-3 highly unsaturated fatty acid (HUFA > or = 20 carbons and > or =3 double bonds) in the total HUFA pool (the n-3 HUFA score) was examined as a potential blood biomarker of omega-3 fatty acids in tissues. The fatty acid composition of total lipid extracts (TLE) and phospholipid (PL) fractions were determined for plasma and erythrocytes samples of human subjects (n = 20) and the n-3 HUFA score and the sum of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were compared. Omega-3 fatty acids in blood and tissues of rats (n = 31) and pigs (n = 48) were also determined and the associations were compared. The n-3 HUFA score is more consistent across plasma and erythrocytes, with strong correlations between TLE and PL in plasma (r = 0.93) and erythrocytes (r = 0.94). The n-3 HUFA score was less variable and blood levels correlated strongly with various animal tissues. The n-3 HUFA score is a useful blood biomarker that does not require the isolation of the PL class thereby supporting high throughput analyses. The strength of association between the n-3 HUFA score and disease risk needs to be examined.

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“…Whether chronic diseases such as diabetes independently alter omega-3 metabolism and levels is controversial (17)(18)(19)(20). The possibility that race, ethanol use, and body size affect fatty acid synthesis has also been raised (17,21,22).…”

Section: Omega-3 Determinants Status and Intake In Healthy Individualsmentioning

confidence: 99%

Review of the Effects of Omega-3 Supplementation in Dialysis Patients

Friedman

Moe²

2006

Clinical Journal of the American Society of Nephrology

117

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Chronic dialysis patients experience a host of conditions that limit quality and length of life, and recent therapeutic strategies have had only modest success in ameliorating many of these problems. By mediating cell membrane function and structure and the synthesis of lipid mediators such as eicosanoids, omega-3 fatty acids may offer dialysis patients a host of therapeutic benefits. Omega-3 fatty acids are derived primarily from dietary sources, and cold-water fish is the main source of eicosapentanoic and docosahexanoic acids, the two major bioactive omega-3 fatty acids. Studies of omega-3 supplementation in dialysis patients describe salutary effects on triglyceride levels, dialysis access patency, and perhaps uremic pruritus and oxidative stress. In contrast, the putative hematologic, antihypertensive, anti-inflammatory, and antiarrhythmic effects are not as well documented. Adverse effects generally have been limited to gastrointestinal complaints. Unfortunately, the preponderance of published studies are characterized by suboptimal study design, small sample sizes, supraphysiologic omega-3 doses that may be difficult to consume for extended periods, little long-term follow-up, and a lack of confirmation of compliance. Not surprising, the 2005 National Kidney Foundation Kidney Disease Outcomes Quality Initiative Clinical Practice Guidelines for Cardiovascular Disease in Dialysis Patients recommend further research in this field. In summary, although preliminary data suggest that omega-3 fatty acids may have clinical benefits, formal recommendations encouraging omega-3 supplementation of dialysis patients are premature until long-term and adverse effects are better defined.

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Alcohol Consumption in Pregnant, Black Women Is Associated With Decreased Plasma and Erythrocyte Docosahexaenoic Acid

Cited by 42 publications

References 78 publications

Biomarker and Dietary Validation of a Canadian Food Frequency Questionnaire to Measure Eicosapentaenoic and Docosahexaenoic Acid Intakes from Whole Food, Functional Food, and Nutraceutical Sources

Biomarker and Dietary Validation of a Canadian Food Frequency Questionnaire to Measure Eicosapentaenoic and Docosahexaenoic Acid Intakes from Whole Food, Functional Food, and Nutraceutical Sources

The Percentage of n‐3 Highly Unsaturated Fatty Acids in Total HUFA as a Biomarker for Omega‐3 Fatty Acid Status in Tissues

Review of the Effects of Omega-3 Supplementation in Dialysis Patients

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