Alcohol consumption in rats treated with lithium carbonate or rubidium chloride

Alexander, George J.; Alexander, Rita B.

doi:10.1016/0091-3057(78)90383-0

Cited by 16 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Li subjects showed consistent increases in alcohol consumption under schedule and body weight conditions that produced no increases in consumption by any TW subject. While these results are contrary to those obtained by Alexander and Alexander (1978), Steinberg and McMillan (1978), and Tsai (1975, 1976), they are consistent with other work (Hines, unpublished results) indicating that lithium facilitates the acquisition of adjunctive water consumption under conditions in which the subject had a choice of drinking either a 10% v/v alcohol solution or tap water. In the latter study, there was no evidence of increased alcohol intake in any of the subjects -even when there was an initial, pre-adjunctive preference for alcohol.…”

Section: Discussioncontrasting

confidence: 57%

“…In general, the animal literature has supported the view that lithium might be of therpeutic benefit in the treatment of alcoholism, indicating that lithium produces a decrease in alcohol consumption under free-choice conditions (Alexander and Alexander 1978), at alcohol concentrations which ordinarily produce a preference for alcohol over water (Steinberg and McMillan 1978), and following the development of a chronic dependence on 30--40% ethanol (Ho and Tsai 1976). However, since lithium is known to produce polydipsia (Crnic 1976), increased water consumption relative to alcohol intake in the above studies may have resulted more from lithium's impact on thirst, rather than on those mechanisms controlling the intake of alcohol.…”

mentioning

confidence: 87%

See 1 more Smart Citation

Lithium effects on adjunctive alcohol consumption in rats

Hines

Henslee

1986

Psychopharmacology

View full text Add to dashboard Cite

Rats receiving chronic administration of lithium chloride (20 mEq/l) in their drinking water were tested for acquisition of adjunctive alcohol (10% v/v) consumption. Contrary to expectations, subjects receiving lithium acquired the adjunctive drinking more rapidly, and under less optimal conditions, than did control subjects. The high death rate in subjects receiving lithium while undergoing a concurrent alcohol withdrawal suggests that particular caution must be observed when lithium is used in the treatment of alcoholics.

show abstract

Section: Discussioncontrasting

confidence: 57%

mentioning

confidence: 87%

Lithium effects on adjunctive alcohol consumption in rats

Hines

Henslee

1986

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Water consumption of rats is decreased by Rb + , but increased by Li + . Alcohol consumption is increased by Rb + , but decreased by Li + (Alexander and Alexander, 1978). Morphineinduced activation in mice is potentiated by Rb + , but antagonized by Li + (Carroll and Sharp, 1971;Sanghvi and Gershon, 1973).…”

Section: Discussionmentioning

confidence: 92%

Effect of RbCl on the circadian rhythm of locomotor activity in the cockroachLeucophaea maderae

Engelmann¹,

Casper²

1984

Journal of Interdisciplinary Cycle Research

View full text Add to dashboard Cite

The period length of the running wheel activity rhythm of cockroaches (Leucophaea maderae), which is lengthened by Li + , was found to be shortened by 0.7% by administering 50 mM RbCl in the drinking water. Replacing the Rb + solution by H 2 O for four weeks did not bring the period length back to the control value. This is probably due to the long biological half life of Rb + in the cells. The phenomenon is another instance in which the effect of Rb + is opposite to that of Li + .

show abstract

“…One group found that lithium decreased voluntary alcohol consumption, but also dramatically increased the severity of withdrawal symptoms (Ho and Tsai, 1976). Another study supported the ability of lithium to attenuate alcohol consumption (Alexander and Alexander, 1978). The mechanisms of these effects are not clear, but the involvement of the cholinergic system has been proposed (Ho and Tsai, 1976).…”

Section: Effect Of Lithium On Alcohol and Morphine Consumption Addicmentioning

confidence: 89%

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

O’Donnell

Gould

2007

Neuroscience & Biobehavioral Reviews

121

View full text Add to dashboard Cite

For nearly as long as lithium has been in clinical use for the treatment of bipolar disorder, depression, and other conditions, investigators have attempted to characterize its effects on behaviors in rodents. Lithium consistently decreases exploratory activity, rearing, aggression, and amphetamine-induced hyperlocomotion; and it increases the sensitivity to pilocarpine-induced seizures, decreases immobility time in the forced swim test, and attenuates reserpine-induced hypolocomotion. Lithium also predictably induces conditioned taste aversion and alterations in circadian rhythms. The modulation of stereotypy, sensitization, and reward behavior are less consistent actions of the drug. These behavioral models may be relevant to human symptoms and to clinical endophenotypes. It is likely that the actions of lithium in a subset of these animal models are related to the therapeutic efficacy, as well the side effects, of the drug. We conclude with a brief discussion of various molecular mechanisms by which these lithium-sensitive behaviors may be mediated, and comment on the ways in which rat and mouse models can be used more effectively in the future to address persistent questions about the therapeutically relevant molecular actions of lithium.

show abstract

Alcohol consumption in rats treated with lithium carbonate or rubidium chloride

Cited by 16 publications

References 9 publications

Lithium effects on adjunctive alcohol consumption in rats

Lithium effects on adjunctive alcohol consumption in rats

Effect of RbCl on the circadian rhythm of locomotor activity in the cockroachLeucophaea maderae

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

Contact Info

Product

Resources

About