Alcohol Consumption Raises HDL Cholesterol Levels by Increasing the Transport Rate of Apolipoproteins A-I and A-II

Silva, Elizabeth R. De Oliveira e; Foster, David M.; Harper, Monnie McGee; Seidman, Cynthia; Smith, Jonathan; Breslow, Jan L.; Brinton, Eliot A.

doi:10.1161/01.cir.102.19.2347

Cited by 259 publications

(121 citation statements)

References 29 publications

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“…A consistent body of evidence suggests a positive relation between moderate alcohol consumption and HDL cholesterol (De Oliveira E Silva et al, 2000;Baer et al, 2002). In a metaanalysis conducted by Rimm et al (1999), 30 g alcohol/day was associated with an increase in HDL cholesterol concentrations of 0.10 mmol/l (3.99 mg/dl) compared to nondrinkers, which is lower than observed in our study.…”

Section: Discussioncontrasting

confidence: 82%

“…Although some studies showed an effect between alcohol consumption and total glyceride level Baer et al, 2002), many did not (Rumpler et al, 1999;De Oliveira E Silva et al, 2000;Nanchahal et al, 2000). The conflicting results may be due to uncontrolled confounding, such as pre-existing hypertriglyceridaemia, obesity, and length of fasting prior to venipuncture.…”

Section: Alcohol and Risk Factors Of Cardiovascular Disease M Burger mentioning

confidence: 99%

“…Moreover, alcohol may delay the cleaning of HDL particles from the blood stream, as demonstrated by intervention studies among primates as well as among men (Cluette-Brown et al, 1985;Gottrand et al, 1999). Two turnover studies, however, failed to show a decreased catabolism of HDL particles in the human body (Malmendier and Delcroix, 1985;De Oliveira E Silva et al, 2000).…”

Section: Alcohol and Risk Factors Of Cardiovascular Disease M Burger mentioning

confidence: 99%

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Alcohol consumption and its relation to cardiovascular risk factors in Germany

Burger

Mensink

Brönstrup³

et al. 2004

Eur J Clin Nutr

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Objective: To analyse the association of alcohol consumption and blood lipids, haemostatic factors, and homocysteine in German adults by gender and age groups. Design: Cross-sectional population-based survey. Setting: Data from the German National Health Interview and Examination Survey 1998, representative for age, gender, community size, and federal state. Subjects: From a sample of 7124 Germans between 18 and 79 y old, 2420 women and 2365 men were selected. Only individuals who were not currently receiving medical treatment or did not have disorders related to cardiovascular disease were selected for this study. Results: Using analyses of variance, mean blood levels of total cholesterol, HDL cholesterol, HDL/total cholesterol ratio, total glycerides, fibrinogen, antithrombin III, and homocysteine adjusted for age, socioeconomic status, East/West Germany residence, body mass index, tobacco use, sports activity, and coffee consumption, if appropriate are presented by alcohol consumption groups (0, 40-10, 410-20, 420-30 and 430 g/day). The HDL/total cholesterol ratio increased with higher alcohol groups up to 10-20 g/day ( þ 15%) for women and 430 g/day ( þ 18%) for men, showing the strongest rise among men aged 55-79 y. Fibrinogen decreased with higher alcohol groups up to 10-20 g/day for women and 20-30 g/day for men. Among women, homocysteine levels showed a U-shaped curve with a minimum of 8.49 mmol/l at 10-20 g alcohol/day (À8%, reference: nondrinking), whereas an inverse association was observed for men. Conclusions: Moderate alcohol consumption is associated with favourable levels of several cardiovascular risk factors. The most favourable cardiovascular risk factor profile among women was observed among those drinking 10-20 g alcohol/day. Beneficial effects seem to be more pronounced among older men.

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Section: Discussioncontrasting

confidence: 82%

Section: Alcohol and Risk Factors Of Cardiovascular Disease M Burger mentioning

confidence: 99%

Section: Alcohol and Risk Factors Of Cardiovascular Disease M Burger mentioning

confidence: 99%

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Alcohol consumption and its relation to cardiovascular risk factors in Germany

Burger

Mensink

Brönstrup³

et al. 2004

Eur J Clin Nutr

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“…The correlation between these two parameters is substantially linear, going from nondrinkers to heavy alcohol drinkers (more than six drinks per day) (Lacko et al, 2000). Apo A1 levels, the major HDL apolipoproteins, also respond favourably to a daily intake of alcohol (De Oliveira e Silva et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis

et al. 2005

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Objective: The aim of the study is to evaluate the effect of moderate Sicilian red wine consumption on cardiovascular risk factors and, in particular, on some inflammatory biomarkers. Methods: A total of 48 subjects of both sexes who were nondrinkers or rare drinkers of moderate red wine were selected and randomly subdivided into two groups assigned to receive with a crossover design a Sicilian red wine (Nero d'Avola or Etna Torrepalino) during meals: Group A (n ¼ 24), in whom the diet was supplemented for 4 weeks with 250 ml/day of red wine, followed by 4 weeks when they returned to their usual wine intake; and Group B (n ¼ 24), in whom the usual wine intake was maintained for 4 weeks, followed by 4 weeks when the diet was supplemented with 250 ml/day of red wine. The following were values measured in all tests: blood glucose, total and HDL-cholesterol and triglycerides, LDL-cholesterol, LDL/HDL ratio, apolipoproteins A1 and B, Lp(a), plasma C-reactive protein, TGFb1, D-Dimer, Factor VII , PAI Ag, t-PA Ag, fibrinogen, oxidized LDL Ab, total plasma antioxidant capacity. Results: At the end of the red wine intake period, LDL/HDL, fibrinogen, factor VII, plasma C-reactive protein and oxidized LDL Ab were significantly decreased, while HDL-C, Apo A1,TGFb1, t-PA, PAI and total plasma antioxidant capacity were significantly increased. Conclusions: Our results show a positive effect of two Sicilian red wines on many risk factors and on some inflammatory biomarkers, suggesting that a moderate consumption of red wine in the adult population is a positive component of the Mediterranean diet.

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“…Another study found that alcohol consumption can raise HDL-C levels by increasing the transport of its apolipoproteins (De Oliveira et al 2000). Does the ALDH2 *504Lys allele also affect lipid levels in the body?…”

Section: Traditional Cardiovascular Risk Factorsmentioning

confidence: 99%

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease

Sun

Shang

et al. 2014

Tohoku J. Exp. Med.

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Coronary artery disease (CAD) is a leading cause of death, and its genetic mechanism has been always a major research concern. Recently, increasing evidence has indicated that the aldehyde dehydrogenase 2 (ALDH2) polymorphism, known as Glu504Lys (rs671), may contribute to CAD development. ALDH2 has been well known as a key enzyme in alcohol metabolism, and subjects with *504Lys allele exist in 30-50% of the East Asian population (6% of the world's population). However, recent studies have indicated that the *504Lys allele of the ALDH2 gene may be associated with the pathogenesis of CAD in a given number of Chinese, Japanese, and Korean people. This discovery has been further confirmed by a genome-wide association study in 2012 that identified the link of ALDH2 Glu504Lys polymorphism to CAD susceptibility. ALDH2 may therefore serve as an important target for CAD intervention. Several studies have suggested that ALDH2 polymorphism plays an important role in the progress of CAD through multiple mechanisms, including the regulation of alcohol consumption, inflammation, endothelial progenitor cells, oxidative stress, asymmetric dimethylarginine, endothelial nitric oxide synthase, and other CAD-promoting factors. Furthermore, the ALDH2 Glu504Lys polymorphism has been shown to be associated with certain traditional cardiovascular risk factors, such as dyslipidemia, hypertension, and diabetes mellitus or hyperglycemia. In this review, we update the current research on the association of the Glu504Lys polymorphism with the susceptibility to CAD. We also highlight and discuss the underlying mechanisms, by which the ALDH2 Glu504Lys polymorphism may be targeted for the prevention and treatment of CAD.

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Alcohol Consumption Raises HDL Cholesterol Levels by Increasing the Transport Rate of Apolipoproteins A-I and A-II

Abstract: Alcohol intake increases HDL-C in a dose-dependent fashion, associated with and possibly caused by an increase in the TR of HDL apolipoproteins apoA-I and -II.

Cited by 259 publications

References 29 publications

Alcohol consumption and its relation to cardiovascular risk factors in Germany

Alcohol consumption and its relation to cardiovascular risk factors in Germany

Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease

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