Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women

Jensen, Majken K.; Mukamal, Kenneth J.; Overvad, Kim; Rimm, Eric B.

doi:10.1093/eurheartj/ehm517

Cited by 55 publications

(65 citation statements)

References 49 publications

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“…A classic example is the study of Fumeron et al ( 17 ) in French males in which a gene-alcohol interaction was described where the effect of B2 on HDL-C concentrations was absent in subjects drinking <25 g/d of alcohol but increased at higher levels. Following this observation, many studies have been published with inconsistent results ( 9,(18)(19)(20)(21)(22)38 ). In a prior study ( 20 ), we found no signifi cant TaqIBalcohol interaction in determining HDL-C in a healthy Mediterranean population.…”

Section: Discussionsupporting

confidence: 48%

“…Regarding prior studies that have analyzed gene-environmental interactions, a lack of consistency is observed. Some studies have reported that alcohol consumption statistically interacts with the TaqIB SNP and modifi es its effects on HDL-C concentrations (17)(18)(19), whereas others have not supported this interaction (20)(21)(22). Likewise, although there is one observational study ( 23 ) in which a statistically signifi cant interaction between the TaqIB-SNP and fat intake was found, those results have not been replicated ( 24 ).…”

Section: Demographic Clinical Anthropometric and Dietary Measurementsmentioning

confidence: 99%

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Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population

Corella

Carrasco

Fitó

et al. 2010

Journal of Lipid Research

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We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the ؊ 4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D´= 0.88; P < 0.001). They were independently associated with higher HDL-C ( P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically signifi cant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were

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Section: Discussionsupporting

confidence: 48%

Section: Demographic Clinical Anthropometric and Dietary Measurementsmentioning

confidence: 99%

Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population

Corella

Carrasco

Fitó

et al. 2010

Journal of Lipid Research

View full text Add to dashboard Cite

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“…Similarly, the newly identifi ed GWA genes, MVK and MMAB, have been recently shown to modulate plasma HDL-C levels depending on carbohydrate consumption ( 225 ), which may help elucidate their role in HDL metabolism. A geneenvironment interaction was also observed between the TaqIB polymorphism in CETP (rs708272) and alcohol consumption ( 226 ).…”

Section: Family Studies In Investigation Of Private Variantsmentioning

confidence: 83%

Genetic causes of high and low serum HDL-cholesterol

Weissglas‐Volkov

Pajukanta

2010

Journal of Lipid Research

180

132

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“…Two previous meta-analyses have documented that CETP genetic variants related to moderate inhibition of CETP activity were associated with favorable blood lipid levels and decreased cardiovascular risk ( 10,11 ). Several observational studies reported that CETP variants might interact with dietary factors, especially dietary fat intake, on HDL cholesterol levels (12)(13)(14)(15), although the fi ndings were not consistently replicated ( 11,(16)(17)(18)(19)(20). In addition, two small short-term diet intervention studies did not demonstrate the interaction between CETP genotype and dietary fat intake ( 21,22 ).…”

Section: Discussionmentioning

confidence: 99%

CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials

Durst

Schwarzfuchs³

et al. 2015

Journal of Lipid Research

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Unfavorable blood lipid levels, such as elevated levels of total cholesterol, LDL cholesterol, and triglycerides, and reduced levels of HDL cholesterol, have been associated with increased risk of CVDs ( 1-3 ). Lipid levels are determined by genetic and environmental factors, as well as their interactions ( 4, 5 ). There has been great interest in investigating cholesteryl ester transfer protein (CETP), a plasma glycoprotein that facilitates the transfer of cholesteryl ester and triglycerides between HDL and other lipoproteins ( 6 ), in relation to blood lipids. CETP defi ciency due to CETP gene mutation causes increased HDL cholesterol levels ( 7,8 ). In patients with low Abstract Little is known about whether cholesteryl ester transfer protein ( CETP ) genetic variation may modify the effect of weight-loss diets varying in fat content on changes in lipid levels. We analyzed the interaction between the CETP variant rs3764261 and dietary interventions on changes in lipid levels among 732 overweight/obese adults from a 2 year randomized weight-loss trial [Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST)], and replicated the fi ndings in 171 overweight/obese adults from an independent 2 year weight-loss trial [Dietary Intervention Randomized Controlled Trial (DIRECT)]. In the POUNDS LOST, participants with the CETP rs3764261 CC genotype on the high-fat diet had larger increases in HDL cholesterol ( P = 0.001) and decreases in triglycerides ( P = 0.007) than those on the low-fat diet at 6 months, while no signifi cant difference between these two diets was observed among participants carrying other genotypes. The gene-diet interactions on changes in HDL-cholesterol and tri glyc erides were replicated in the DIRECT (pooled P for interaction ≤ 0.01). Similar results on trajectory of changes in HDL cholesterol and triglycerides over the 2 year intervention were observed in both trials. Our study provides replicable evidence that individuals with the CETP rs3764261 CC genotype might derive greater effects on raising HDL cholesterol and lowering triglycerides by choosing a low-carbohydrate/high-fat weight-loss diet instead of a low-fat diet. -Qi, Q

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Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women

Abstract: The association of alcohol with HDL-C levels was modified by CETP TaqIB2 carrier status, and there was also a suggestion of a gene-environment interaction on the risk of CHD.

Cited by 55 publications

References 49 publications

Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population

Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population

Genetic causes of high and low serum HDL-cholesterol

CETP genotype and changes in lipid levels in response to weight-loss diet intervention in the POUNDS LOST and DIRECT randomized trials

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