Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

Green, Ridgely Fisk; Stoler, Joan M.

doi:10.1016/j.ajog.2007.02.028

Cited by 37 publications

(27 citation statements)

References 128 publications

(144 reference statements)

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“…Important evidence also comes from a Human Genome Epidemiology Network review reporting an increased risk of a number of adverse developmental outcomes in children related to maternal and foetal polymorphisms of the ADH1B gene 49 . Findings of individual studies were conflicting, possibly due to relatively small sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Prenatal alcohol exposure and offspring cognition and school performance. A ‘Mendelian randomization’ natural experiment

Zuccolo

Lewis

Smith

et al. 2013

International Journal of Epidemiology

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Background There is substantial debate as to whether moderate alcohol use during pregnancy could have subtle but important effects on offspring, by impairing later cognitive function and thus school performance. The authors aimed to investigate the unconfounded effect of moderately increased prenatal alcohol exposure on cognitive/educational performance.Methods We used mother-offspring pairs participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) and performed both conventional observational analyses and Mendelian randomization using an ADH1B variant (rs1229984) associated with reduced alcohol consumption. Women of White European origin with genotype and self-reported prenatal alcohol consumption, whose offspring’s IQ score had been assessed in clinic (N = 4061 pairs) or Key Stage 2 (KS2) academic achievement score was available through linkage to the National Pupil Database (N = 6268), contributed to the analyses.Results Women reporting moderate drinking before and during early pregnancy were relatively affluent compared with women reporting lighter drinking, and their children had higher KS2 and IQ scores. In contrast, children whose mothers’ genotype predisposes to lower consumption or abstinence during early pregnancy had higher KS2 scores (mean difference +1.7, 95% confidence interval +0.4, +3.0) than children of mothers whose genotype predisposed to heavier drinking, after adjustment for population stratification.Conclusions Better offspring cognitive/educational outcomes observed in association with prenatal alcohol exposure presumably reflected residual confounding by factors associated with social position and maternal education. The unconfounded Mendelian randomization estimates suggest a small but potentially important detrimental effect of small increases in prenatal alcohol exposure, at least on educational outcomes.

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Section: Discussionmentioning

confidence: 99%

Prenatal alcohol exposure and offspring cognition and school performance. A ‘Mendelian randomization’ natural experiment

Zuccolo

Lewis

Smith

et al. 2013

International Journal of Epidemiology

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“…Research has shown that teratogenic effects of PAE can be influenced by multiple maternal factors, including hormone status (particularly hormones of the HPA axis), nutrition, oxidative stress level, age, parity and years of drinking [117][118][119][120]. Genetic profiles of both mother and fetus may also alter the metabolism of alcohol and risk of physical birth defects, prenatal mortality, learning and other neurobehavioral deficits in the offspring [121][122][123]. Familial patterns of heavy drinking during pregnancy, which may be associated with family and cultural customs, may also result in an increased incidence of ND-PAE.…”

Section: Familial Patternmentioning

confidence: 99%

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Kable

O’Connor

Olson

et al. 2015

Child Psychiatry Hum Dev

107

101

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Over the past 40 years, a significant body of animal and human research has documented the teratogenic effects of prenatal alcohol exposure (PAE). Neurobehavioral Disorder associated with PAE is proposed as a new clarifying term, intended to encompass the neurodevelopmental and mental health symptoms associated with PAE. Defining this disorder is a necessary step to adequately characterize these symptoms and allow clinical assessment not possible using existing physically-based diagnostic schemes. Without appropriate diagnostic guidelines, affected individuals are frequently misdiagnosed and treated inappropriately (often to their considerable detriment) by mental health, educational, and criminal justice systems. Three core areas of deficits identified from the available research, including neurocognitive, self-regulation, and adaptive functioning impairments, are discussed and information regarding associated features and disorders, prevalence, course, familial patterns, differential diagnosis, and treatment of the proposed disorder are also provided.

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“…Genetic or nutritional differences between the study populations also might affect the risk of damage to the developing visual system secondary to exposure to alcohol. [31][32][33] This prospective study examined the ocular structures and visual function comprehensively in unselected children with prenatal alcohol exposure and unexposed controls. Eye examinations were performed on all exposed subjects, not just those who had phenotypic changes related to alcohol damage.…”

Section: Discussionmentioning

confidence: 99%