Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome

Mhéalóid, Áine Ní; Łukasik, T.; Power, William; Murphy, Conor C

doi:10.18240/ijo.2018.07.09

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…A clinical audit reported that alcohol delamination meets the typical safety and efficacy standards. 11 In our case series, alcohol-assisted epithelial debridement was effective and safe in the treatment of RCE. All our patients had complete resolution within 2 weeks and had no recurrence after a mean follow-up period of 27 months.…”

Section: Discussionmentioning

confidence: 56%

Alcohol-assisted epithelial debridement for treatment of recurrent corneal erosion: a case series

Cheng

Chow

Yiu

2019

Hong Kong Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 56%

Alcohol-assisted epithelial debridement for treatment of recurrent corneal erosion: a case series

Cheng

Chow

Yiu

2019

Hong Kong Journal of Ophthalmology

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“…Medical treatments include lubricating ointments, hypertonic NaCl drops and hypertonic ointments [ 4 ]. Erythromycin or tetracycline ophthalmic ointments can reduce matrix metalloproteinase-9, which could contribute to the recurrent erosions [ 32 ]. Collagen shields and bandage contact lenses (BCL) [ 33 ] have also been used for recurrent erosions, but it is preferable not to use BCL for an extended period because of the potential problem of bacterial ulceration.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Clinical Outcome of Low-Temperature Plasma Ablation Treatment for Recurrent Corneal Erosions

Lin

Zhu

Yang

et al. 2022

JCM

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Purpose: To observe the therapeutic effect of low-temperature plasma ablation in treating patients with recurrent corneal erosions (RCEs). Materials and Methods: From 2020 to 2022, 35 participants with unilateral RCEs voluntarily enrolled. Here, 35 eyes of 35 patients were treated with low-temperature plasma ablation (coblation). All surgeries were performed by the same doctor (X.H.). The coblation went back and forth over the entire erosion area around five times for about five minutes. After the operation, patients were scheduled for follow-up visits at the outpatient clinic after 1 month, 3 months, 6 months, and 12 months, and at the end of the trial. During every visit, each patient underwent an evaluation of their ocular symptoms utilizing the following: pain score, intraocular pressure, slit lamp biomicroscopic examination, dry eye analysis, corneal topography, and corneal in vivo confocal microscopy (IVCM). Results: The mean follow-up time was 12.4 ± 6.1 months, ranging from 6 to 29 months. Of the 35 patients who had low-temperature plasma ablation, 32 eyes (91.43%) were completely symptom-free and three (8.57%) eyes had repeated episodes of recurrent corneal erosions after the surgery, at 3, 10, and 12 months, respectively. The typical RCE morphologic abnormalities observed in IVCM included the deformation and relaxation of the corneal epithelium, disorganized stromal fibers, reduced nerve fiber density, and disordered organization. After low-temperature plasma ablation, the loose cysts disappeared, and the epithelium became solid and tight. There was no obvious difference in the intraocular pressure (p = 0.090) or corneal astigmatism (p = 0.175) before and after treatment. The mean pain score decreased significantly, with a preoperative score of 7.7 ± 2.4 and postoperative score of 1.1 ± 1.8 (p < 0.001). The mean corneal thickness decreased from 562.6 ± 42.2 mm to 549.6 ± 26.9 mm (p = 0.031). The mean non-invasive keratograph tear meniscus height (NIKTMH) decreased from 0.210 ± 0.054 mm to 0.208 ± 0.045 mm (p = 0.001), and the mean TBUT decreased from 6.191 ± 2.811 s to 5.815 ± 2.802 s (p < 0.001), which manifested as a slight worsening of dry eyes. In one case, the patient’s corneal astigmatism became more severe, which may be related to the high instantaneous energy when the operation did not flush in a timely manner, and it was recovered after 6 months. Conclusion: Low-temperature plasma ablation is an effective and safe procedure to treat patients with recurrent corneal erosions.

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Three-year outcomes of alcohol delamination of corneal epithelium for recurrent corneal erosions of traumatic etiology

Teh

Chua

Reddy

2021

Indian Journal of Ophthalmology

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Purpose: Alcohol delamination of the corneal epithelium (ADCE) is a therapeutic option for patients with recurrent corneal erosion (RCE) who do not respond to nonsurgical management of lubricants and extended wear contact lens. The aim of the study is to report on three-year efficacy and safety of ADCE for RCE of traumatic etiology. Methods: This is a retrospective review of consecutive patients who underwent ADCE for traumatic RCE in a local hospital between January 2010 and January 2020. The outcomes at a 3-year follow-up review are included. Nonsurgical therapy used; intra- and postoperative complications were recorded. ADCE was only offered to those who remained symptomatic despite maximum topical lubrications and/or extended wear contact lens. Success was defined as the absence of recurrence of corneal erosion. Results: Twenty-six eyes of 26 patients with RCE caused by trauma underwent ADCE. The mean age of patients was 39 years. The follow-up period was a minimum of 36 months. Three eyes (11.5%) had recurrence of corneal erosion after ADCE at the 3-year follow-up. Recurrence was noted at months 2, 23, and 36 postoperatively in these patients. All patients reported significant improvement in symptoms associated with recurrent erosion. Ten eyes (38.5%) stopped all topical lubricants postoperatively. No intra- or postoperative complications were noted in our study. Conclusion: This study documents the long-term safety and efficacy of alcohol delamination of corneal epithelium at 3 years for patients with RCE of traumatic origin.

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Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome

Abstract: ALD is an efficacious and cost-effective primary surgical intervention for RCES.

Cited by 3 publications

References 19 publications

Alcohol-assisted epithelial debridement for treatment of recurrent corneal erosion: a case series

Alcohol-assisted epithelial debridement for treatment of recurrent corneal erosion: a case series

Long-Term Clinical Outcome of Low-Temperature Plasma Ablation Treatment for Recurrent Corneal Erosions

Three-year outcomes of alcohol delamination of corneal epithelium for recurrent corneal erosions of traumatic etiology

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