Alcohol drinking and risk of non-Hodgkin's lymphoma

Tavani, Alessandra; Gallus, Silvano; Vecchia, Carlo La; Franceschi, Silvia

doi:10.1038/sj.ejcn.1601245

Cited by 17 publications

(11 citation statements)

References 16 publications

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“…14,16,19,30,38,40,42,43,55 Our results were also in accordance with the Interlymph findings in so far as in the pooled analysis no protective effect of alcohol was observed for European centers. 47 Similarly, the findings of the 2 other studies reporting an inverse association between alcohol intake and development of overall NHL were not based on European study populations, as one was a case-control study carried out in Japan 24 and the other one was a large American cohort study.…”

Section: Discussionsupporting

confidence: 81%

Tobacco smoking, alcohol drinking and non‐Hodgkin's lymphoma: A European multicenter case‐control study (Epilymph)

Besson

Brennan

Becker

et al. 2006

Intl Journal of Cancer

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To study the role of tobacco smoking and alcohol drinking in the etiology of non-Hodgkin's lymphoma (NHL), we conducted a multicenter case-control study in Spain, France, Germany, Italy, Ireland and Czech Republic between 1998 and 2004, which included 1,742 cases of NHL and 2,465 controls matched on age, sex and recruitment area. Tobacco smoking was not associated with the risk of NHL overall or with risk of specific histological subtypes. Similarly, there was no association between alcohol drinking and the risk of NHL overall or across histological subtypes. However, a protective effect of alcohol drinking was observed among men (OR 5 0.76, 95% CI 5 0.62-0.93) and in non-Mediterranean countries (OR 5 0.73, 95% CI 5 0.61-0.86). There was no evidence of interaction between alcohol drinking and tobacco smoking in NHL etiology. The results of this large-scale European study did not support an association between tobacco and NHL and suggested a protective effect of alcohol on development of NHL for men and in non-Mediterranean countries. ' 2006 Wiley-Liss, Inc.Key words: lymphoma; non-Hodgkin's; tobacco; alcohol; EuropeThe incidence of non-Hodgkin's lymphoma (NHL) has increased considerably in the last few decades in all countries with reliable information. 1 In Europe, between the early and the late 1990s, the rise in mortality was 5% for men and 8% for women. 2 There is no clear explanation of this phenomenon. To date, the established risk factors for NHL are autoimmune diseases, 3 infection with human immunodeficiency virus and human T-cell leukemia/lymphoma virus, 4 but these factors explain only a small proportion of the etiology of NHL. The role of tobacco smoking and alcohol drinking in the development of NHL remains uncertain partly due to the small sample sizes of previous epidemiologic studies. Recently, the International Lymphoma Epidemiology Consortium (Interlymph) has reported results based on pooled data of studies from Europe, 32-34 USA 22,28,39,45 and Australia. 46 In this analysis based on 6,492 cases of NHL and 8,683 controls, a slight inverse association was found between alcohol intake and the development of NHL. 47 The analysis of the effect of tobacco smoking, based on 6,594 cases of NHL and 8,892 controls, reported a slightly increased risk of NHL overall and of B-cell follicular lymphoma in particular. 48 Thus, we have attempted to confirm the results of the pooled analysis using data from an independent European multicenter case-control study (Epilymph). Material and methodsOur investigation was conducted in 7 European countries (Czech Republic, Finland, France, Germany, Ireland, Italy, and Spain), but data from Finland were not included in this analysis because of methodological issues, in particular, controls were not matched to cases on age, sex and residence area, as done in other study centers, and the present study is based on data from 6 countries.Histologically or cytologically confirmed incident cases of lymphoma were recruited from 1998 to 2004 (Table I). Cases were classified ac...

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Section: Discussionsupporting

confidence: 81%

Tobacco smoking, alcohol drinking and non‐Hodgkin's lymphoma: A European multicenter case‐control study (Epilymph)

Besson

Brennan

Becker

et al. 2006

Intl Journal of Cancer

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“…18 At hospital admission, these patients were enrolled as cases in a case-control study conducted by the same Institution with the aim of providing information on the role of some sociodemographic factors, tobacco smoking, alcohol drinking, food consumption and risk of NHL. 3,11,19 All study participants signed an informed consent, according to the recommendations of the Ethical Committee. All subjects were interviewed by trained interviewers, using structured questionnaires, which included information on age, education, other socioeconomic factors, a problem-oriented medical history, dietary, drinking and smoking habits.…”

Section: Methodsmentioning

confidence: 99%

“…Three studies 4,7,8 have suggested that alcohol consumption reduces the risk of NHL whereas others have found increased NHL risks among alcohol drinkers 9,10 or no relationships. 5,11 Whether tobacco smoking and alcohol drinking influence the prognosis of patients with lymphomas is still unclear. To our knowledge, only a recent population-based prospective study conducted in Italy 12 investigated the issue.…”

Section: Introductionmentioning

confidence: 99%

The impact of tobacco smoking and alcohol drinking on survival of patients with non‐Hodgkin lymphoma

Talamini

Polesel

Spina

et al. 2008

Intl Journal of Cancer

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Tobacco smoking and alcohol consumption have not been clearly related to the risk of non-Hodgkin lymphoma (NHL), and the impact of these two factors on survival of NHL patients has received little attention. Cases were 268 subjects with incident histologically-confirmed NHL, admitted as inpatients to the Division of Medical Oncology, between 1983 and 2002. These individuals were enrolled as cases in case-control studies conducted at the same institution over the same period. For all patients clinical (histological subtype, major prognostic factors and treatment) and epidemiological data (smoking and drinking habits) were available. Survival analysis was performed using Kaplan-Meier methods. Hazard ratio (HR) was estimated by Cox proportional hazard model. Compared to never smokers, patients who smoked ≥20 cigarettes/day had higher risks of death (HR 5 1.70, 95% confidence interval (CI): 1.06-2.73) and lower survivals at 5 years (60 and 46%, respectively). Likewise, patients who drunk ≥4 drinks/day showed 1.69-fold higher probability of death (95% CI: 1.04-2.76) in comparison to drinkers of <2 drinks/day (5-year survival: 47 and 67%, respectively). When combining exposure to alcohol and tobacco, no excess of death emerged in light drinkers (<4 drinks/ day), irrespective of their smoking habits, but higher risks of death emerged among heavy drinkers. In the present study, heavy tobacco smoking, and particularly, heavy alcohol drinking were associated with poor survival in NHL patients. Our findings strongly encourage physicians to advice NHL patients to stop smoking and diminish alcohol consumption to obtain improvements in the course of NHL. ' 2007 Wiley-Liss, Inc.

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“…368,369,373,374,376,382,388,[394][395][396][397][398][399] In a recent pooled analysis of 9 case-control studies, Morton et al 398 reported a significant inverse association with alcohol (pooled OR 5 0.83, 95% CI: 0.76-0.89), which did not vary with frequency or duration of intake, or by type of alcoholic beverage (OR for beer only, compared to nondrinkers 5 0.85, 95% CI: 0.76-0.95; OR for wine only 5 0.85, 95% CI: 0.74-0.99; OR for liquor only 5 0.90, 95% CI: 0.74-1.09). In a subgroup analysis of 4 of the studies with sufficient data, relative risk estimates were lower for current drinkers (pooled OR 5 0.73, 95% CI: 0.64-0.84) than for former drinkers (pooled OR 5 0.95, 95% CI: 0.80-1.14), compared to nondrinkers.…”

Section: Lifestyle and Personal Factors Tobacco And Alcohol Usementioning

confidence: 99%