Alcohol Drinking and the Risk of Chronic Kidney Damage: A Meta‐Analysis of 15 Prospective Cohort Studies

Liu, Deming; Xu, Jing; Liu, Fang; Wang, Xinjing; Yang, Huanhuan; Li, Xinli

doi:10.1111/acer.14112

Cited by 19 publications

(12 citation statements)

References 54 publications

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“…To establish a prevention program against CKD, modifiable lifestyle risk factors for CKD should be identified and effective interventions for these defined. Some of the lifestyle risk factors that could be used as promising targets for CKD prevention include obesity [7], smoking [8,9], alcohol consumption [10,11], sleep deprivation [12,13], and unhealthy diet [14].…”

Section: Introductionmentioning

confidence: 99%

Frequency of Breakfast, Lunch, and Dinner and Incidence of Proteinuria: A Retrospective Cohort Study

et al. 2020

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Although multiple studies have revealed a close association of skipping breakfast with cardiometabolic diseases, few studies have reported its association with chronic kidney disease (CKD). Furthermore, there is scant reporting on the clinical impacts that skipping lunch and dinner has on cardiometabolic diseases and CKD. This retrospective cohort study, including 5439 female and 4674 male workers of a national university in Japan who underwent annual health checkups between January 2005 and March 2013, aimed to assess an association of frequencies of breakfast, lunch, and dinner with incidence of proteinuria (dipstick urinary protein ≥1+). The incidence of proteinuria was observed in 763 (14.0%) females and 617 (13.2%) males during the median 4.3 and 5.9 years of the observational period, respectively. In females, skipping breakfast as well as skipping dinner, but not lunch, were associated with the incidence of proteinuria (adjusted hazard ratios of breakfast frequency of “every day”, “sometimes”, and “rarely”: 1.00 (reference), 1.35 (1.09–1.66), and 1.54 (1.22–1.94), respectively; those of dinner frequency of “every day” and “≤sometimes”: 1.00 (reference) and 1.31 (1.00–1.72), respectively). However, no association was observed in male workers. Skipping breakfast and skipping dinner were identified as risk factors of proteinuria in females, but not in males.

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Section: Introductionmentioning

confidence: 99%

Frequency of Breakfast, Lunch, and Dinner and Incidence of Proteinuria: A Retrospective Cohort Study

et al. 2020

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“…High alcohol consumption was associated with an increased risk of completes suicide ( 58 ) ( Figure 5 ). For chronic kidney damage ( 23 ), the low, moderate and high alcohol consumption were all correlated to reduce the incidence ( Figures 3 – 5 ). What's more, moderate alcohol consumption was found to strongly decrease the risk of frailty ( 21 ) in this study ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 97%

Alcohol and Health Outcomes: An Umbrella Review of Meta-Analyses Base on Prospective Cohort Studies

Zhong

Chen

Wang

et al. 2022

Front. Public Health

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An umbrella review of meta-analyses was performed to summarize the evidence of associations between alcohol consumption and health outcomes and to assess its credibility. Meta-analyses of prospective cohort studies reporting the associations of alcohol consumption with health outcomes were identified. We recalculated the random-effects summary effect size and 95% confidence interval, heterogeneity, and small-study effect for each meta-analysis and graded the evidence. Fifty-nine publications reporting 224 meta-analyses of prospective cohort studies with 140 unique health outcomes were included, in which there were 49 beneficial associations and 25 harmful associations with nominally statistically significant summary results. But quality of evidence was rated high only for seven beneficial associations (renal cell carcinoma risk, dementia risk, colorectal cancer mortality, and all-cause mortality in patients with hypertension for low alcohol consumption; renal cell carcinoma risk, cardiovascular disease (CVD) risk in patients with hypertension and all-cause mortality in patients with hypertension for moderate consumption) and four harmful associations (cutaneous basal cell carcinoma risk for low alcohol consumption; cutaneous basal cell carcinoma risk and cutaneous squamous cell carcinoma risk for moderate alcohol consumption; hemorrhagic stroke risk for high alcohol consumption). In this umbrella review, only 11 health outcomes (5 in low alcohol consumption, 5 in moderate alcohol consumption and 1 in high alcohol consumption) with statistically significant showed high quality of epidemiologic evidence. More robust and larger prospective studies are needed to verify our results.

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“…Previous studies have shown that compared with no drinking, regular and occasional binge drinking were associated with 2.2-fold and a 2.0-fold higher risks of CKD progression, respectively. This association was particularly evident in patients who had decreased kidney function and proteinuria [ 38 , 39 ]. In addition, we also found a significant correlation between previous CKD and D-AKI (adjusted OR = 2.33, 95% CI: 1.07-5.08, P = 0.033).…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Hospitalized Patients with Drug‐Induced Acute Kidney Injury and Associated Risk Factors: A Case‐Control Study

Guo

Yan

et al. 2020

BioMed Research International

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Background. Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clinical characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. Methods. A retrospective study among hospitalized patients was conducted in July 2019 based on the Adverse Drug Events Active Surveillance and Assessment System-2 developed by the authors. Four controls were matched with each case according to the matching criteria. The risk factors for D-AKI were identified by binary multivariate logistic regression. Results. A total of 23,073 patients were hospitalized in July 2019, 21,131 of whom satisfied the inclusion criteria. The independent risk factors for D-AKI consisted of alcohol abuse (odds ratio (OR), 2.05; 95% confidence interval (CI), 1.04-4.07), nonsteroidal anti-inflammatory drug (NSAID) use (OR, 2.39; 95% CI, 1.25-4.58), diuretic use (OR, 2.64; 95% CI, 1.42-4.92), prior anemia (OR, 4.10; 95% CI, 1.94-8.67), and prior chronic kidney disease (OR, 2.33; 95% CI, 1.07-5.08). Conclusions. The occurrence of D-AKI in hospitalized patients had significant associations with alcohol abuse, combination therapy with NSAIDs or diuretics, and prior anemia or chronic kidney disease. Clinicians should meticulously follow patients with the above characteristics.

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Alcohol Drinking and the Risk of Chronic Kidney Damage: A Meta‐Analysis of 15 Prospective Cohort Studies

Cited by 19 publications

References 54 publications

Frequency of Breakfast, Lunch, and Dinner and Incidence of Proteinuria: A Retrospective Cohort Study

Frequency of Breakfast, Lunch, and Dinner and Incidence of Proteinuria: A Retrospective Cohort Study

Alcohol and Health Outcomes: An Umbrella Review of Meta-Analyses Base on Prospective Cohort Studies

Clinical Characteristics of Hospitalized Patients with Drug‐Induced Acute Kidney Injury and Associated Risk Factors: A Case‐Control Study

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