Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas

Abstract

Background/AimsAge, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma.MethodsPatients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group.Results212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group.ConclusionsThis study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma.

Associations between amount of smoking and alcohol intake and risk of colorectal neoplasm

“…Similar to our findings, several studies have reported that alcohol consumption is not related to the risk for CRN 12,17,21 ; however, other studies have demonstrated that alcohol intake is associated with risk for CRN. 15,[18][19][20] Although the pathophysiological mechanisms by which alcohol consumption exerts its carcinogenic effect have not been fully defined, the proposed mechanisms include generation of acetaldehydes, oxidative stress due to induction of cytochrome P 4502E1, and nutritional deficiencies (i.e., lack of folic and retinoic acid as well as malnutrition itself). 35 In a Danish study, alcohol intake was associated with a significantly increased risk of rectal cancer, but not colon cancer.…”

“…14 Additionally, several studies have assessed the association between alcohol consumption and the presence of CRN, but the results have been inconsistent. [15][16][17] Some studies have reported alcohol intake as a risk factor for CRN, 15,[18][19][20] while several other studies revealed that alcohol consumption was not related to the risk for CRN. 12,17,21 Data on the risk for CRN according to amount of alcohol consumption might help to clarify the association.…”

Predictors of High-Risk Adenoma Occurrence at Surveillance Colonoscopy in Patients Who Undergo Colorectal Adenoma Removal

“…Several factors such as multiple adenomas, large size of adenoma, male sex, obesity, metabolic syndrome, and smoking are associated with recurrent adenoma [6][7][8][9][10][11][12][13][14][15][16][17][18][19]. However, the association between age and recurrent adenoma has differed from study to study.…”

Endoscopic Improvement of the Adenoma Detection Rate during Colonoscopy - Where Do We Stand in 2015?

“…Food supplementation such as multivitamin intake and calcium supplementation also seems to be beneficial in this context [33]. Alcohol consumption was associated with an increased risk for advanced adenomas [34]. …”