Alcohol during pregnancy and atopic dermatitis in the offspring

Linneberg, Allan; Petersen, Janne; Grønbæk, Morten; Benn, Christine Stabell

doi:10.1111/j.1365-2222.2004.02101.x

Cited by 45 publications

(60 citation statements)

References 33 publications

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“…In a recent report evaluating a Japanese cohort, maternal alcohol intake during pregnancy significantly increased the risk of atopic eczema before age 3 and before age 5. 49 These data are in agreement with other authors, who demonstrated an increased risk of atopic dermatitis in early infancy 50 and during the first 7 years of life in alcohol-exposed offspring. 51 Nevertheless, the data on foetal alcohol’s effect on the development of asthma is less convincing.…”

Section: Foetal Alcohol Exposure and Risk Of Adverse Pulmonary Outcomessupporting

confidence: 91%

In utero alcohol effects on foetal, neonatal and childhood lung disease

Gauthier

Brown

2017

Paediatric Respiratory Reviews

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Summary Maternal alcohol use during pregnancy exposes both premature and term newborns to the toxicity of alcohol and its metabolites. Foetal alcohol exposure adversely effects the lung. In contrast to the adult “alcoholic lung” phenotype, an inability to identify the newborn exposed to alcohol in utero has limited our understanding of its effect on adverse pulmonary outcomes. This chapter will review advances in biomarker development of in utero alcohol exposure. We will highlight the current understanding of in utero alcohol’s toxicity to the developing lung and immune defense. Finally, we will present recent clinical evidence describing foetal alcohol’s association with adverse pulmonary outcomes including bronchopulmonary dysplasia, viral infections such as respiratory syncytial virus and allergic asthma/atopy. With research to define alcohol’s effect on the lung and translational studies accurately identifying the exposed offspring, the full extent of alcohol’s effects on clinical respiratory outcomes of the newborn or child can be determined.

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Section: Foetal Alcohol Exposure and Risk Of Adverse Pulmonary Outcomessupporting

confidence: 91%

In utero alcohol effects on foetal, neonatal and childhood lung disease

Gauthier

Brown

2017

Paediatric Respiratory Reviews

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“…Several epidemiological studies have linked alcohol consumption to IgE sensitization against inhalant allergens, but only 1 of these was prospective [12,13,14,15,16]. Furthermore, maternal alcohol consumption during pregnancy has been linked to early atopic phenotypes (cord blood IgE and early-onset atopic dermatitis) in the offspring, indicating that alcohol may influence the immune system in utero [17, 18]. One recently published experimental study confirmed the ability of alcohol to induce a marked increase in total serum IgE and suppression of the allergen-specific Th1-dependent IgG response (IgG2a), but in this mouse model with intraperitoneally administered ovalbumin alcohol did not influence the allergen-specific IgE response [19].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Remission of Specific IgE Aeroallergen Sensitization from Age of 40 to 60 Years, and Association with Alcohol Consumption

Linneberg¹,

Friedrich²,

Husemoen³

et al. 2009

Int Arch Allergy Immunol

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Background: Data on incidence and long-term persistence of IgE aeroallergen sensitization in older adults are limited. Alcohol consumption is a strong immune-modulator with a significant impact on the IgE response. Objectives: We aimed to assess the incidence and remission of aeroallergen sensitization from the age of 40 to 60 years. Furthermore, we examined the relationship of alcohol consumption to the prevalence and incidence of aeroallergen sensitization. Methods: In 1976–1977, a total of 1,200 people born in 1936 and randomly selected from the general population were invited for a health examination (1,052 were examined). At 60 years, they were invited for a re-examination (695 were examined). Stored serum samples from both examinations were analyzed consecutively for serum-specific IgE to aeroallergens by using a qualitative multi-allergen immunoassay. Results: We observed a total of 32 (7.1% of those not sensitized at 40 years) incident cases and 35 (41.1% of those sensitized at 40 years) remittent cases of aeroallergen sensitization over this 20 year period. Persistent as well as incident sensitization was significantly associated with self-reported atopic disease at 60 years. Alcohol consumption (>14 drinks per week) at 40 years was significantly associated with a higher prevalence of sensitization at 40 years, but not with the incidence of sensitization. Conclusions: In older adults, aeroallergen sensitization as reflected by serum-specific IgE positivity to aeroallergens is a dynamic process. Both persistent and incident sensitization was associated with atopic disease. Further studies are needed to clarify the influence of alcohol on the allergen-specific IgE response.

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“…Whether fetal alcohol exposure has an effect on allergic disease development is contentious [42–44], possibly being confounded by other environmental stimuli. Maternal obesity before or during pregnancy has been reported to increase risk of childhood asthma [45].…”

Section: Dna Methylation and Allergic Diseasementioning

confidence: 99%

Epigenomics and Allergic Disease

et al. 2013

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Allergic disease development is affected by both genes and the environment, and epigenetic mechanisms are hypothesized to mediate these environmental effects. In this article, we discuss the link between the environment, DNA methylation and allergic disease, as well as questions of causality inherent to analyses of DNA methylation. From the practical side, we describe characteristics of allergic phenotypes and contrast different epidemiologic study designs used in epigenetic research. We examine methodological considerations, how best to conduct preprocessing and analysis of DNA methylation data sets, and the latest methods, technologies and discoveries in this rapidly advancing field. DNA methylation and other epigenetic marks are firmly entwined with allergic disease, a link that may hold the basis for future allergic disease diagnosis and treatment.

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Alcohol during pregnancy and atopic dermatitis in the offspring

Abstract: The results suggest that alcohol during pregnancy increases the risk of early-onset AD in predisposed infants.

Cited by 45 publications

References 33 publications

In utero alcohol effects on foetal, neonatal and childhood lung disease

In utero alcohol effects on foetal, neonatal and childhood lung disease

Incidence and Remission of Specific IgE Aeroallergen Sensitization from Age of 40 to 60 Years, and Association with Alcohol Consumption

Epigenomics and Allergic Disease

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