Alcohol: Effects on Nutritional Status, Lipid Profile and Blood Pressure

Toffolo,

doi:10.4021/jem128e

Cited by 12 publications

(12 citation statements)

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“…The lipid profiles were affected differently in rats exposed to [EP] or [Alc] for different lengths of time. These findings were consistent with previous studies indicating that both alcohol [ 22 , 23 ] and pterocarpans [ 24 ] affected hepatic metabolism. The effects on cholesterol levels were similar in the [EP] and [Alc] groups, while these treatments produced different effects on triglyceride levels at 15 days.…”

Section: Discussionsupporting

confidence: 93%

Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function

Silva

Souza

Reichert

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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This study evaluated the influence of the alcohol present in a formulation of the antiophidic phytotherapic tincture, Específico-Pessôa, on rat blood biochemical and hematological parameters, and on organ histology. Three groups of rats were treated orally for 10, 15, or 30 days; one group received the tincture, the other received alcohol alone, and the third was a control group. The results of this study indicated that cholesterol levels were significantly increased after 10 days in the alcohol and tincture groups, although these decreased after 30 days in the tincture group. Triglyceride levels were significantly reduced after 15 days in the tincture group and after 30 days in the alcohol and tincture groups. A higher creatinine level was observed in the alcohol and tincture groups after 15 and 30 days. The uric acid levels in these groups were reduced at 10 and 30 days, although this metabolite was elevated at 15 days in the alcohol group. Hydropic multifocal degeneration with lymphohistiocytic infiltration and some polymorphonuclear cells was observed in the livers of rats treated with either the tincture or alcohol. These data demonstrate the importance of considering the potential actions of the alcohol present in pharmaceutical formulations.

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Section: Discussionsupporting

confidence: 93%

Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function

Silva

Souza

Reichert

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…The increase in cholesterol levels at 13.98 mg.dL -1 in the [ALC1] group may reflect the increased absorption of dietary cholesterol or the induction of cholesterol absorption by alcohol (Latour et al, 1999). These findings were consistent with previous studies indicating that alcohol affected lipid metabolism (Toffolo et al, 2012) with increased cholesterol levels in rats treated with alcohol (Silva et al, 2015).…”

Section: Resultssupporting

confidence: 90%

Evaluation of the toxic effects of the bottled medicine (garrafada) containing the Echinacea purpurea, Annona muricata, Tabebuia avellanedae, Pterodon emarginatus and Uncaria tomentosa in rats

Indras¹,

Marek²,

Penteado³

et al. 2020

J. Med. Plants Res.

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This study evaluated if the oral administration of a bottled medicine containing Echinacea, Graviola, Purple Ipe, Sucupira and Cat's claw could cause changes in biochemical, coagulation, hematological and histopathological parameters in rats. This study arised after a report to Ceatox of a patient who used a bottled medicine and developed hematological, renal and histopathological changes. The bottled medicine possesses 4.32 mg alcohol.mL-1 and by the phytochemical screening and UV/Scan tests showed some classes of secondary metabolites. In experiments using Wistar rats, two treatments were performed, single dose and 30 days, administering water, alcohol and bottled medicine by gavage. In the single dose treatment, alterations of uric acid, cholesterol, creatinine, alkaline phosphatase, iron and glucose (p<0.05) were found. Already in the 30 days treatment were alterations of uric acid, total and indirect bilirubins, creatinine, alkaline phosphatase, glucose, triglycerides, erythrocytes and leukocytes (p<0.05), and hepatic sinusoidal dilatation. The data showed that the alcohol present in the bottled medicine can alter biochemical, hematological parameters and cause liver damage in rats. The bottled medicine, although not showing alterations in important biochemical and hematological parameters, had more pronounced liver histopathological alterations.

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“…Seu metabolismo hepático altera vias metabó licas, incluindo a oxidação lipídica, e o seu aproveitamento calórico dependerá do estado nutricional 5 . Indivíduos que relatam consumo moderado ou frequente, mas que ainda não são dependentes, podem ter maior acúmulo de gordura abdominal e periférica do que não bebedores 6 . Além disso, o consumo de bebidas alcoólicas pode interferir na absorção de nutrientes importantes para o aumento de massa muscu lar, causar desidratação por estimular a diurese 5 e compro meter a força, a potência e a endurance muscular 7 .…”

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Consumo de álcool por frequentadores de academia de ginástica

Oliveira

Almas

Castro

et al. 2014

J. bras. psiquiatr.

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Objetivo Como não há na literatura informações sobre o perfil de consumo alcoólico entre desportistas, o objetivo deste trabalho foi avaliar o perfil de consumo alcoólico por frequentadores de academia de ginástica associando com a antropometria e a intensidade do treino. Métodos Foram convidados a participar do estudo indivíduos praticantes de musculação, por no mínimo seis meses, com idade entre 20 e 40 anos, de ambos os sexos. Foram realizadas medidas antropométricas e de composição corporal. Para avaliação do consumo alcoólico, utilizou-se o questionário AUDIT (The Alcohol Use Disorders Identification Test). A intensidade do treino foi identificada por meio de um questionário semiestruturado. Resultados Dos participantes, 74,1% (n = 35) disseram ter feito uso de álcool. Além disso, 19 voluntários (38,8%) apresentaram comportamento de risco para o consumo de álcool (AUDIT ≥ 8). Considerando o consumo alcoólico em binge, 32 voluntários (65,3%) consumiram seis ou mais doses de álcool em alguma ocasião no ano anterior, não havendo diferença entre os sexos. A adiposidade corporal estava acima dos valores recomendados entre os que relataram consumo em binge. Não houve associação entre a intensidade do treinamento físico e o consumo de álcool em binge, nem entre a intensidade do treinamento e o comportamento de risco para o consumo de álcool. Conclusão A maioria dos desportistas apresentou consumo de bebidas alcoólicas no padrão binge, não sendo associado à intensidade do treinamento. Este não condiz com os seus objetivos ao frequentar academias de ginástica. A adiposidade corporal estava acima dos valores recomendados.

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Alcohol: Effects on Nutritional Status, Lipid Profile and Blood Pressure

Cited by 12 publications

References 84 publications

Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function

Influence of the Alcohol Present in a Phytotherapic Tincture on Male Rat Lipid Profiles and Renal Function

Evaluation of the toxic effects of the bottled medicine (garrafada) containing the Echinacea purpurea, Annona muricata, Tabebuia avellanedae, Pterodon emarginatus and Uncaria tomentosa in rats

Consumo de álcool por frequentadores de academia de ginástica

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