Alcohol extract of Tribulus terrestris ameliorates liver of mice exposed to cadmium acetate

Abstract

Background: Tribulus terrestris is known as food supplements and therapeutic agent. Objective: This study was presented to evaluate antitoxicity of fruit alcohol extracted from Tribulus terrestris to be used against heavy metal (cadmium) in female of albino mice.Methods: Twenty mice were examined in this experiment, and they were divided into three groups. The first group was a control group, while the second group was quaffed cadmium 6mg/kg, and third group was quaffed cadmium 6mg/kg and fruit alcohol extract of Tribulus terrestris 200mg/kg for ten days. Histological change was studied in the livers of these mice.Results: The histological sections of the liver in the mice exposed to cadmium have shown inflammation and necrosis in hepatocytes around central vein. Moreover, the liver was also hypertrophy, karyomegaly and increases glycogenesis. The results of the cadmium-exposed mice treated with the extract of Tribulus terrestris showed that the damage in the liver was slight. It showed normal cell shape and hepatic plate. It also showed simple inflammation and hypertrophy in a small space.Conclusion: The fruits of Tribulus terrestris can remove toxicity, protect our bodies (especially liver) against heavy metal such as cadmium.

Evaluation of Garlic efficiency on precipitated lead chloride in hepatocytes of mice

“…After 21 days of took garlic solution plus 8.3 mg of lead chloride, the histopathological changes showed regeneration of hepatocytes appear enlarged and dark nuclei due to mitosis although the high dose of lead chloride, but others hepatocytes still swelling and loss of sinusoids which refer to regeneration which indicates the effect of garlic in returning hepatocytes to normal (Figure 7), this regeneration may be due to the presence of organ sulfur compounds in garlic that have many effect on drug metabolizing enzymes, antioxidant properties, antimicrobial, antithrombotic, hypolipidemic, antiarthritic, hypoglycemic and antitumor activity [29]. Finally, This study is in agreement with other studies that emphasize decreasing chemical toxicity by using natural products [30].…”

The Hepatoprotective and Anti-Nephrotoxic Potential of Methanolic Extract of a Polyherbal Preparation in CCl4-Induced Liver Injury Model of Wistar Rats

“…23 In a study, T terrestris at the dose of 200 mg/kg protects the liver against cadmium toxicity. 24 Recently, Okorie et al 25 demonstrated the M pruriens leaf extract effect on the liver. The result showed that ALP, AST, ALT, and albumin were found to be statistically significant among the treated groups when compared with the control group.…”