Alcohol, glucose metabolism and diabetes

Avogaro, Angelo; Tiengo, Antonio

doi:10.1002/dmr.5610090205

Cited by 49 publications

(34 citation statements)

References 130 publications

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“…The potential risks of alcohol in diabetic patients have recently been reviewed [15]. In diabetic patients, alcohol may induce hypoglycaemia, especially during prolonged fasting or in the presence of sulphonylurea medication [36]. However, the same study revealed no alteration of glucose homeostasis in diabetic patients who consumed a moderate amount of alcohol with meals.…”

Section: Discussionmentioning

confidence: 99%

Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men

et al. 2004

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Aims/hypothesis. Type 2 diabetes mellitus is characterised by heightened inflammation and endothelial dysfunction. Moderate alcohol intake has been associated with a reduced risk of cardiovascular disease in Type 2 diabetic patients. It remains to be determined whether there is an association between alcohol and inflammation in individuals with diabetes. Methods. We investigated the relationship between alcohol intake and inflammation in 726 of 18,159 men who returned blood samples in the Health Professionals Follow-up Study and had confirmed Type 2 diabetes at blood draw. Results. In age-adjusted analyses, alcohol intake was associated with lower levels of HbA 1 c, fibrinogen, soluble tumour necrosis factor receptor-2 (sTNF-R2) and soluble vascular adhesion molecule-1 (sVCAM-1), and with higher levels of HDL cholesterol and adiponectin (p value for trends <0.05). After adjustment for age, HbA 1 c, insulin use, fasting status, smoking, BMI, physical activity, aspirin use, prevalence of cardiovascular disease and dietary factors, each additional drink per day was related to increased HDL cholesterol (0.053 mmol/l, p<0.0001) and adiponectin (0.8 µg/ml, p=0.01), and decreased sTNFR-2 (73 pg/ml, p=0.03), fibrinogen (0.302 µmol/l, p=0.02) and sVCAM-1 (33 ng/ml, p=0.02). The relationship between alcohol and inflammatory biomarkers persisted when subjects were stratified according to HbA 1 c levels. Conclusions/interpretation. Moderate alcohol intake may have a beneficial effect on markers of inflammation and endothelial dysfunction in Type 2 diabetic patients.Keywords Alcohol · Cardiovascular disease · Diabetes mellitus · Inflammation

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Section: Discussionmentioning

confidence: 99%

Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men

et al. 2004

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“…The references in included articles and relevant reviews [12][13][14][15][16][17] were checked for additional studies of interest. Included were original peer-reviewed publications on observational cohorts or nested case-control studies in type 2 diabetic populations on the relationship between alcohol consumption and the incidence of diabetic complications.…”

Section: Methodsmentioning

confidence: 99%

Meta-analysis of the relationship between alcohol consumption and coronary heart disease and mortality in type 2 diabetic patients

Koppes

Dekker

Hendriks³

et al. 2006

Diabetologia

114

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Aims/hypothesis: This systematic review examines the relationship between alcohol consumption and long-term complications of type 2 diabetes. Meta-analyses could only be performed for total mortality, mortality from CHD, and CHD incidence, because the availability of articles on other complications was too limited. Materials and methods: A PubMed search through to September 2005 was performed and the reference lists of relevant articles examined. Among the relevant articles there were six cohort studies reporting on the risk of total mortality and/or fatal and/or incident CHD in alcohol non-consumers and in at least two groups of alcohol consumers. Results: Statistical pooling showed lower risks in alcohol consumers than in non-consumers (the reference category). The relative risk (RR) of total mortality was 0.64 (95% CI 0.49-0.82) in the <6 g/day category. In the higher alcohol consumption categories (6 to <18, and ≥18 g/day), the RRs of total mortality were not significant. Risks of fatal and total CHD were significantly lower in all three categories of alcohol consumers (<6, 6 to <18 and ≥18 g/day) than in nonconsumers, with RRs ranging from 0.34 to 0.75. Conclusions/interpretation: This meta-analysis shows that, as with findings in the general population, moderate alcohol consumption is associated with a lower risk of mortality and CHD in type 2 diabetic populations.

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“…This increased secretory response may be a result of the alcohol-induced stimulation of in- sulin secretion by gastrointestinal secretogogues or an insulinogenic effect of corticotropin peptides present in cells of the gastroentero-pancreatic system (22)(23)(24)(25). On the other hand, diabetogenic effects of high alcohol intake include its contribution to excess caloric intake and obesity, induction of pancreatitis, disturbance of carbohydrate and glucose metabolism, and impairment of liver function (7,26). Large amounts of alcohol decrease insulin-mediated glucose uptake, and alcoholics have decreased glucose tolerance (25,27,28).…”

Section: Statistical Analysesmentioning

confidence: 99%

Alcohol Consumption and Risk for Development of Impaired Fasting Glucose or Type 2 Diabetes in Middle-Aged Japanese Men

Suzuki²,

2003

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OBJECTIVE -To investigate the association between alcohol consumption and risk for development of diabetes.RESEARCH DESIGN AND METHODS -We examined 2,953 Japanese male office workers aged 35-59 years who did not have impaired fasting glucose (IFG) (a fasting plasma glucose concentration of 6.1-6.9 mmol/l), type 2 diabetes (a fasting plasma glucose concentration of Ն7.0 mmol/l or receipt of hypoglycemic medication), medication for hypertension, or a history of cardiovascular disease. Fasting plasma glucose concentrations were measured at periodic annual health examinations from May 1994 through May 2001.RESULTS -There was a U-shaped association between alcohol consumption and the incidence of IFG or type 2 diabetes during 7 years of follow-up, with the lowest incidence at alcohol intake of 23.0 -45.9 g ethanol/day. After controlling for age, family history of diabetes, BMI, cigarette smoking, and physical activity, the relative risk for development of IFG or type 2 diabetes compared with alcohol consumption of 23.0 -45.9 g ethanol/day was 1.51 (95% CI, 1.07-2.13), 1.31 (95% CI, 0.93-1.84), 1.18 (95% CI, 0.87-1.61), and 1.43 (95% CI, 1.01-2.02) with alcohol consumption of 0, 0.1-22.9, 46.0 -68.9, and Ն69.0 g ethanol/day, respectively (P for quadratic trend ϭ 0.016). Analyses by presence or absence of a risk factor revealed that a U-shaped association was more evident in older men, men without a family history of diabetes, and nonsmokers.CONCLUSIONS -These results indicate that moderate alcohol consumption among apparently healthy Japanese men is associated with reduced risk for development of IFG or type 2 diabetes.

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Alcohol, glucose metabolism and diabetes

Cited by 49 publications

References 130 publications

Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men

Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men

Meta-analysis of the relationship between alcohol consumption and coronary heart disease and mortality in type 2 diabetic patients

Alcohol Consumption and Risk for Development of Impaired Fasting Glucose or Type 2 Diabetes in Middle-Aged Japanese Men

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