Alcohol Has a Dose-Related Effect on Parasympathetic Nerve Activity During Sleep

Sagawa, Yohei; Kondo, Hideaki; Matsubuchi, Namiko; Takemura, Takaubu; Kanayama, Hironobu; Kaneko, Yoshihiko; Kanbayashi, Takashi; Hishikawa, Yasuo; Shimizu, Tetsuo

doi:10.1111/j.1530-0277.2011.01558.x

Cited by 42 publications

(25 citation statements)

References 34 publications

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“…Many previous studies used moderate or low doses of alcohol and some data suggests that the REM rebound effect may be diminished or eliminated increasing doses of alcohol (Arnedt et al, 2011; Knowles et al, 1968; Roehrs, 1991; Sagawa et al, 2011; Williams et al, 1983). Indeed, the only other study of the effects of alcohol on sleep in late adolescents also failed to show a REM sleep rebound with increasing doses of alcohol, but similar to the current results did find a whole night suppression effect (Williams et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

The Acute Effects of Alcohol on Sleep Architecture in Late Adolescence

Chan

Trinder

Andrewes

et al. 2013

Alcoholism Clin & Exp Res

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Background Alcohol consumption is prevalent in late adolescence, however little is known about its effect on sleep in this group. In mature adults, alcohol decreases sleep onset latency (SOL) and sleep efficiency (SE) and increases wake after sleep onset (WASO). It also increases slow wave sleep (SWS) and decreases REM sleep in the first half of the night, with the inverse occurring in the second half. Alcohol’s effect on sleep during late adolescence is of interest given that this age group shows both dramatic increases in alcohol consumption, and significant developmental changes in the central nervous system. This study examined the effect of alcohol on sleep architecture in women and men aged 18–21 years and whether previously reported sleep architecture effects may have been as an artificial result of changes to sleep cycle length. Methods 24 (12 female) healthy 18–21 year old light social drinkers (19.1±1.0yrs) underwent two conditions: pre-sleep alcohol (Target BAC 0.10%) and placebo administered under controlled conditions, followed by standard polysomnography. Results In the alcohol condition, mean breath alcohol concentration (BAC) at lights out was 0.084 ±0.016%. Time in bed, total sleep time and sleep onset latency (all p>.05) did not differ between conditions. However, there was less REM (p=.011) and more stage 2 sleep (p=.035) in the alcohol condition. Further, alcohol increased SWS (p=.02) and decreased REM sleep (p<.001) in the first half of the night and disrupted sleep in the second half, with increased WASO (interaction: p=.034), and decreased SE (p=.04) and SWS (p=.01) and no REM sleep rebound in the second half of the night (p=.262). Additionally, alcohol had no effect on sleep cycle length (p=.598). Conclusions The results were broadly consistent with the adult literature with the novel extension that half night sleep architecture effects could not be attributed to changes in sleep cycle length. However, alcohol did not reduce SOL, or result in a REM rebound following reduced REM in the first half of the night. The results suggest that the effects of alcohol on sleep are modified by sleep’s prevailing developmental stage.

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Section: Discussionmentioning

confidence: 99%

The Acute Effects of Alcohol on Sleep Architecture in Late Adolescence

Chan

Trinder

Andrewes

et al. 2013

Alcoholism Clin & Exp Res

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“…Alcohol initially acts as a sedative. Commonly reported phenomena include shortened sleep onset latency (MacLean and Cairns 1982; Roehrs et al 1999; Williams, MacLean, and Cairns 1983; Stone 1980; Scrima et al 1982) and increased SWS in the first half of the night (Williams, MacLean, and Cairns 1983; Van Reen, Jenni, and Carskadon 2006; Sagawa et al 2011; Rundell et al 1972; Chan et al 2013; MacLean and Cairns 1982; Prinz et al. 1980; Feige et al 2006; Arnedt, Rohsenow, et al 2011).…”

Section: 0 Acute Effects Of Alcohol On Sleepmentioning

confidence: 99%

“…1980; Feige et al 2006; Arnedt, Rohsenow, et al 2011). REM sleep is suppressed, with a longer latency to REM sleep and decreased REM sleep in the first half of the night (Williams, MacLean, and Cairns 1983; Van Reen, Jenni, and Carskadon 2006; Sagawa et al 2011; Rundell et al 1972; Chan et al 2013) or across the whole night (Van Reen, Jenni, and Carskadon 2006; Williams, MacLean, and Cairns 1983; Roehrs et al 1999; Rundell et al 1972; Roehrs, Yoon, and Roth 1991; Arnedt, Rohsenow, et al 2011). In the second half of the night, sleep is disrupted, with increased wakefulness and/or stage 1 sleep.…”

Section: 0 Acute Effects Of Alcohol On Sleepmentioning

confidence: 99%

Alcohol and the sleeping brain

Colrain

Nicholas

Baker

2014

Handbook of Clinical Neurology

139

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Alcohol acts as a sedative that interacts with several neurotransmitter systems important in the regulation of sleep. Acute administration of large amounts of alcohol prior to sleep leads to decreased sleep onset latency and changes in sleep architecture early in the night, when blood alcohol levels are high, with subsequent disrupted, poor quality sleep later in the night. Alcohol abuse and dependence are associated with chronic sleep disturbance, lower slow wave sleep, and more rapid eye movement sleep than normal, that last long into periods of abstinence and may play a role in relapse. The chapter outlines the evidence for acute and chronic alcohol effects on sleep architecture and sleep EEG, evidence for tolerance with repeated administration, and possible underlying neurochemical mechanisms for alcohol’s effects on sleep. Also discussed are sex differences as well as effects of alcohol on sleep homeostasis and circadian regulation. Evidence for the role of sleep disruption as a risk factor for developing alcohol dependence is discussed in the context of research conducted in adolescents. The utility of sleep evoked potentials in the assessment of the effects of alcoholism on sleep and the brain and in abstinence-mediated recovery is also outlined. The chapter concludes with a series of questions that need to be answered to determine the role of sleep and sleep disturbance in the development and maintenance of problem drinking and the potential beneficial effects of the treatment of sleep disorders for maintenance of abstinence in alcoholism.

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“…These differences in subjective sleep quality reflect objective differences in sleep efficiency (percentage of time in bed spent asleep) and depth of sleep (Keklund & Akerstedt, 1997). In particular, alcohol consumption decreases the proportion of total sleep-time spent in rapid eye movement (REM) sleep and increases the proportion of time spent in Stage 1 (light non-REM) sleep (Sagawa et al, 2011; Van Reen et al, 2006). Examined in parcels of time roughly corresponding to when the body is metabolizing alcohol (first half of night) and eliminating alcohol (second half of night), increases in amount of Stage 3 (deep non-REM) sleep in the first 3 hours of sleep-time are accompanied by decreases in Stage 3 sleep later in the night (Stone, 1980; Williams et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

The within-person association between alcohol use and sleep duration and quality in situ: An experience sampling study

Lydon

Ram

Conroy

et al. 2016

Addictive Behaviors

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Objective Despite evidence for detrimental effects of alcohol on sleep quality in laboratory studies, alcohol is commonly used as a self-prescribed sleep aid. This study examined the within-person associations of alcohol use with sleep duration and quality in everyday life to gain insight into the ecological validity of laboratory findings on the association between sleep and alcohol. Method A sample of 150 adults (age 19–89 years) were followed for 60+ days as part of an intensive experience sampling study wherein participants provided daily reports of their alcohol use, sleep duration, and sleep quality. Within-person and between-person associations of daily sleep duration and quality with alcohol use were examined using multilevel models. Results A significant, negative within-person association was observed between sleep quality and alcohol use. Sleep quality was lower on nights following alcohol use. Sleep duration did not vary as a function of within-person variation in alcohol use. Conclusions In line with laboratory assessments, alcohol use was associated with low sleep quality but was not associated with sleep duration, suggesting that laboratory findings generalize to everyday life. This examination of individuals’ daily lives suggests that alcohol does not systematically improve sleep quality or duration in real life.

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Alcohol Has a Dose-Related Effect on Parasympathetic Nerve Activity During Sleep

Abstract: Acute ethanol intake inhibits parasympathetic nerve activity and results in predominance of sympathetic nerve activity during sleep, in a dosage-dependent manner. The results of this study suggest that ethanol interferes with the restorative functions of sleep.

Cited by 42 publications

References 34 publications

The Acute Effects of Alcohol on Sleep Architecture in Late Adolescence

The Acute Effects of Alcohol on Sleep Architecture in Late Adolescence

Alcohol and the sleeping brain

The within-person association between alcohol use and sleep duration and quality in situ: An experience sampling study

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