Alcohol, Hormones, and Metabolism

Gordon, Gary G.; Lieber, Charles S.

doi:10.1007/978-1-4615-3320-7_3

Cited by 8 publications

(4 citation statements)

References 278 publications

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“…Yet, while genetics research is often at the forefront of the discussion of predisposition to alcoholism and other psychopathologies (Heilig et al 2011; Kenna et al 2012), hormones are also essential to this discussion as fundamental causative mechanisms associated with craving, drinking, treatment and links to other medical conditions caused by alcoholism. While the evidence is strong that alcohol use causes significant medical problems (Gordon and Lieber 1992), the direction of causation between neuroendocrine changes that occur as a result of alcoholism or predispose one to becoming AD are not yet fully known and are the subject of intense research.…”

Section: Introductionmentioning

confidence: 99%

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

et al. 2012

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Section: Introductionmentioning

confidence: 99%

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

et al. 2012

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“…Consumption of alcohol can lead to dehydration (Gordon and Lieber, 1992;Gordon and Southern, 1982). To determine whether the body weight loss in TE mice was caused by dehydration, we measured carcass water content and urinary output.…”

Section: Discussionmentioning

confidence: 99%

“…Consumption of alcohol can lead to dehydration (Gordon and Lieber, 1992;Gordon and Southern, 1982). Carcass water content and urinary output were measured to determine whether the body weight loss in TE mice was due to dehydration.…”

Section: Carcass Water and Lipid Contentmentioning

confidence: 99%

Alcohol Consumption Promotes Body Weight Loss in Melanoma‐Bearing Mice

Núñnez

Carter

Meadows

2002

Alcoholism Clin & Exp Res

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Background: Alcohol consumption is an important risk factor for cancer. Little is known about its effects on cancer progression. Previously, we showed that high ethanol consumption inhibited metastasis of B16BL6 melanoma-bearing mice without affecting primary tumor growth. On the other hand, ethanolconsuming tumor-bearing (TE) mice exhibited decreased survival and decreased body weight as compared to water-drinking, tumor-bearing (TW) mice. The focus of this study was to determine how alcohol promotes weight loss in melanoma-bearing mice.Methods: Female, C57BL/6 mice were given water or 20% w/v ethanol in the drinking water for 3 weeks to 6 months before subcutaneous inoculation of 1 ϫ 10 6 B16BL6 melanoma cells. Mice continued to receive the same fluids. Biochemical parameters were evaluated at various times after tumor inoculation. Body weight, water content, tumor weight and carcass fat content were determined at necropsy.Results: TW mice elicted a modest weight loss. This response was magnified 2-fold by alcohol consumption. The weight loss in TE mice is not caused by dehydration, decreased energy intake, or loss of skeletal muscle mass. It resulted specifically from loss in body fat. Other alterations associated with the fat loss in TE mice were: (1) decreased glucose, (2) elevated fatty acids, (3) elevated ␤-hydroxybutyrate, (4) elevated glucagon, and (5) increased leptin levels in plasma. Body temperature decreased about 2.9°C in TE mice. Metabolic rate increased in TW mice. The fat loss due to alcohol consumption in tumor-bearing mice was not due to increased metabolic rate.Conclusions: The response elicited by alcohol consumption in tumor-bearing mice is complex and associated with alterations in metabolism and hormones. These findings suggest that alcohol abuse could be a risk factor for cancer patients because it invokes a strong depletion of body fat. This could facilitate wasting and shorten survival time.

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“…Chronic heavy drinkers often have insufficient dietary intake of glucose. Without eating, glycogen stores are exhausted in a few hours (Gordon, GG & CS Lieber, 1992). In addition, the body's glucose production is inhibited while alcohol is being metabolized (Sneyd, JGT, 1989).…”

Section: Ald and Hypoglycemiamentioning

confidence: 99%

Inflammation and Hypoglycemia: The Lipid Connection

Tirosh¹

2011

Diabetes - Damages and Treatments

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Alcohol, Hormones, and Metabolism

Cited by 8 publications

References 278 publications

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

Alcohol Consumption Promotes Body Weight Loss in Melanoma‐Bearing Mice

Inflammation and Hypoglycemia: The Lipid Connection

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