Alcohol increases cigarette smoking: A laboratory demonstration

Mintz, Jim; Boyd, Gayle M.; Rose, Jed E.; Charuvastra, V. Charles; Jarvik, Murray E.

doi:10.1016/0306-4603(85)90001-2

Cited by 103 publications

(60 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, regarding polydrug abuse, one drug may precede self-adminsitration of a second drug. For example, cigarette smokers frequently report increases in craving and smoking behavior following the consumption of alcohol (Burton & Tiffany, 1997;Glautier, Clements, White, Taylor, & Stolerman,1996;Mintz, Boyd, Rose, Charuvastra, & Jarvik, 1985;Mitchell, de Wit, & Zacny, 1995). Similarly, nicotine has been demonstrated to have CS effects for the US effects of alcohol .…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Recovery During, But not Following, Extinction of the Discriminative Stimulus Effects of Nicotine in Rats: Reinstatement of Stimulus Control

Troisi

2003

Psychol Rec

View full text Add to dashboard Cite

Extinction of the discriminative stimulus effects of drugs has received little research attention. Using a one-lever foodreinforcement (VI-1 min) operant procedure with rats (N = 16), the studies reported here assessed extinction, spontaneous recovery, and reinstatement of responding to the discriminative stimulus effects of nicotine. Experiment 1 found evidence for retention of differential responding to IP administrations of nicotine after a 3-month (87 days) delay following acquisition. Experiment 2 compared spontaneous recovery of discriminative control 2 and 4 weeks following extinction. Additionally, the impact of noncontingent reinforcement on discriminative control was evaluated (reinstatemen~. During extinction training, nicotine (.4 mg/kg) or saline was administered 15 min prior to each 15-min session, as they were during training, but responding was not reinforced under either stimulus condition. Spontaneous recovery (SR) of responding under the SD condition occurred during a session (11 th) preceded by two consecutive S'" sessions. Matched by response rate, 8 rats were randomly assigned to either a 2-week delay group or a 4-week delay group. There was no evidence for SR of discriminated responding to the drugs 2 or 4 weeks following the final extinction session. Between-group comparisons further revealed that SR did not vary as a function of delay following extinction. Reinstatement of stimulus control was observed following 2 brief sessions of noncontingent food delivery (levers retracted and conducted in the absence of the drug cues). These results suggest that the maintenance and extinction of the discriminative stimulus effects of nicotine are temporally stable. Theoretical ideas regarding drug self-administration, craving, and therapy are entertained.

show abstract

Section: Discussionmentioning

confidence: 99%

Spontaneous Recovery During, But not Following, Extinction of the Discriminative Stimulus Effects of Nicotine in Rats: Reinstatement of Stimulus Control

Troisi

2003

Psychol Rec

View full text Add to dashboard Cite

show abstract

“…alcohol abuse, alcohol dependence and TD) has been conducted using clinical populations (e.g. Mintz et al, 1985;York and Hirsch, 1995) or college students (e.g. Jackson et al, 2000).…”

Section: Alcohol-tobacco Comorbiditymentioning

confidence: 99%

Alcohol and tobacco use disorders in a general population: short-term and long-term associations from the St. Louis Epidemiological Catchment Area Study

Jackson

Sher

Wood

et al. 2003

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Background-Although research using clinical and convenience samples has shown alcohol use disorders (AUD) to be highly comorbid with tobacco dependence (TD), little work has examined this association prospectively using population-based data. The AUD-TD association was prospectively examined using data from the St. Louis Epidemiological Catchment Area (ECA) Study and its 1-year follow-up as well as from a 16-year follow-up on a subsample of ECA data.Method-Respondents were 3004 (2564, 85%, at Wave 2) participants in the St. Louis household ECA sample, including 444 participants at Year 16 follow-up. At baseline, the sample was predominately White (58%; 38% Black), female (60%), and 44.3 years. Past-year AUD and TD were diagnosed at all waves according to DSM-III criteria.Results-AUDs and TDs were cross-sectionally associated at Years 1, 2, and 16. Controlling for demographics, Year 1 TD prospectively predicted Year 2 AUD, and Year 1 AUD prospectively predicted Year 16 TD. We found evidence for prediction of onset and persistence of both AUD and TD at short-term but not long-term follow-up. Prospective findings were reduced and no longer reached significance when concurrent diagnoses at follow-up were included in the regression models.Conclusions-We observed short-term and long-term associations between AUD and TD. These associations were mediated through concurrent diagnoses with the other substance use disorder.

show abstract

“…While a number of studies document that alcohol reliably increases smoking behavior (e.g., Glautier et al 1996;Griffiths et al 1976;Mintz et al 1985;Mitchell et al 1995;Shiffman et al 1994) and potentiates nicotine reward (Rose et al 2004), relatively fewer studies examine the impact of nicotine on alcohol self-administration. In preclinical studies, acute administrations of nicotine decreased alcohol self-administration behavior (Katner et al 1997;Nadel et al 1998), whereas chronic administration of nicotine increased alcohol intake in alcohol-experienced rats (Blomqvist et al 1996;Clark et al 2001;Lê et al 2000;Smith et al 1999;Soderpalm et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration

et al. 2007

View full text Add to dashboard Cite

Rationale-Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior.Objective-The primary aim of this within-subject, double-blind study was to examine whether transdermal nicotine replacement (0 mg vs 21 mg/day) altered response to a low-dose priming drink and subsequent ad libitum drinking behavior.Materials and methods-Subjects (n=19) were non-treatment-seeking, non-dependent heavy drinkers who were daily smokers. Six hours after transdermal patch application, subjective and physiological responses to a priming drink [designed to raise blood alcohol levels (BALs) to 0.03 g/ dl] were assessed. This was followed by a 2-h self-administration period where subjects could choose to consume up to eight additional drinks (each designed to raise BALs by 0.015 g/dl) or to receive monetary reinforcement for drinks not consumed.Results-We found that 6 h after patch application, tobacco craving associated with withdrawal relief was decreased, and systolic blood pressure and heart rate were increased in the active patch condition compared to the placebo patch condition. Subjective intoxication in response to the priming drink was attenuated in the active nicotine patch condition compared to 6 h of nicotine deprivation (i.e., placebo patch). During the self-administration period, subjects had longer latencies to start drinking and consequently appeared to consume fewer drinks when administered the active patch compared to the placebo patch.Conclusions-In heavy drinkers, transdermal nicotine replacement compared to mild nicotine deprivation attenuated subjective and physiological alcohol responses and delayed the initiation of drinking.

show abstract

Alcohol increases cigarette smoking: A laboratory demonstration

Cited by 103 publications

References 13 publications

Spontaneous Recovery During, But not Following, Extinction of the Discriminative Stimulus Effects of Nicotine in Rats: Reinstatement of Stimulus Control

Spontaneous Recovery During, But not Following, Extinction of the Discriminative Stimulus Effects of Nicotine in Rats: Reinstatement of Stimulus Control

Alcohol and tobacco use disorders in a general population: short-term and long-term associations from the St. Louis Epidemiological Catchment Area Study

Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration

Contact Info

Product

Resources

About