Alcohol-induced alterations in ERD/ERS during an auditory memory task

Krause, Christina M.; Aromäki, Anu S.; Sillanmäki, Lauri; Åström, Teresia; Alanko, Katarina; Salonen, E.; Peltola, O.

doi:10.1016/s0741-8329(01)00204-x

Cited by 20 publications

(21 citation statements)

References 45 publications

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“…The dose-related impact of alcohol on auditory transient evoked 40-Hz responses during a selective attention task was investigated; higher doses of alcohol significantly suppressed the early evoked gamma responses in both attended and non-attended conditions, suggesting cognitive impairment or lack of sensory binding (Jaaskelainen et al, 2000). Administration of alcohol was shown to decrease early synchronization during auditory encoding and increase later desynchronization in theta (4–6 Hz), low alpha (6–8 Hz), and high alpha (8–10 Hz) bands (Krause et al, 2002). This indicates that alcohol has disorganizing effects on the brain’s electric oscillatory systems in theta and lower alpha frequency ranges during cognitive processing.…”

Section: Acute Effects Of Alcohol On the Brain In Social Drinkersmentioning

confidence: 99%

Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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Neurocognitive deficits associated with impairments in various brain regions and neural circuitries, particularly involving frontal lobes, have been associated with chronic alcoholism, as well as with a predisposition to develop alcohol use and related disorders (AUDs). AUD is a multifactorial disorder caused by complex interactions between behavioral, genetic, and environmental liabilities. Neuroelectrophysiological techniques are instrumental in understanding brain and behavior relationships and have also proved very useful in evaluating the genetic diathesis of alcoholism. This chapter describes findings from neuroelectrophysiological measures (electroencephalogram, event-related potentials, and event-related oscillations) related to acute and chronic effects of alcohol on the brain and those that reflect underlying deficits related to a predisposition to develop AUDs and related disorders. The utility of these measures as effective endophenotypes to identify and understand genes associated with brain electrophysiology, cognitive networks, and AUDs has also been discussed.

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Section: Acute Effects Of Alcohol On the Brain In Social Drinkersmentioning

confidence: 99%

Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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“…Furthermore, given their high heritability and the genetic links of theta oscillations with alcohol dependence, changes in theta band have been suggested as an endophenotype of vulnerability to alcoholism (Porjesz et al, 2005; Begleiter and Porjesz, 2006). In light of this evidence, it is surprising to note that research on the acute effects of alcohol on theta oscillations has been exceedingly limited (Krause et al, 2002). Fifth, previous EEG studies using cognitive tasks have observed increased theta power during the engagement of executive functions (McEvoy et al, 2001; Jensen and Tesche, 2002; Brier et al, 2010) particularly in prefrontal areas (Kovacevic et al, submitted).…”

Section: Introductionmentioning

confidence: 99%

Event-Related Theta Power during Lexical-Semantic Retrieval and Decision Conflict is Modulated by Alcohol Intoxication: Anatomically Constrained MEG

et al. 2012

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Language processing is commonly characterized by an event-related increase in theta power (4–7 Hz) in scalp EEG. Oscillatory brain dynamics underlying alcohol’s effects on language are poorly understood despite impairments on verbal tasks. To investigate how moderate alcohol intoxication modulates event-related theta activity during visual word processing, healthy social drinkers (N = 22, 11 females) participated in both alcohol (0.6 g/kg ethanol for men, 0.55 g/kg for women) and placebo conditions in a counterbalanced design. They performed a double-duty lexical decision task as they detected real words among non-words. An additional requirement to respond to all real words that also referred to animals induced response conflict. High density whole-head MEG signals and midline scalp EEG data were decomposed for each trial with Morlet wavelets. Each person’s reconstructed cortical surface was used to constrain noise-normalized distributed minimum norm inverse solutions for theta frequencies. Alcohol intoxication increased reaction time and marginally affected accuracy. The overall spatio-temporal pattern is consistent with the left-lateralized fronto-temporal activation observed in language studies applying time-domain analysis. Event-related theta power was sensitive to the two functions manipulated by the task. First, theta estimated to the left-lateralized fronto-temporal areas reflected lexical-semantic retrieval, indicating that this measure is well suited for investigating the neural basis of language functions. While alcohol attenuated theta power overall, it was particularly deleterious to semantic retrieval since it reduced theta to real words but not pseudowords. Second, a highly overlapping prefrontal network comprising lateral prefrontal and anterior cingulate cortex was sensitive to decision conflict and was also affected by intoxication, in agreement with previous studies indicating that executive functions are especially vulnerable to alcohol intoxication.

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“…Although event-related brain oscillations have been intensively studied during cognitive processing (Basar-Eroglu et al, 1996a,b;Basar et al, 1997Basar et al, , 1999Basar et al, , 2000Basar et al, , 2001aKlimesch, 1997Klimesch, , 1999Klimesch et al, 1997aKlimesch et al, , 2001aSchurmann et al, 1997Basar, 1999, 2001;Doppelmayr et al, 2000;Sakowitz et al, 2000;Rohm et al, 2001;Kolev et al, 2001;Sauseng et al, 2002), only a few studies have attempted to investigate oscillatory changes related to alcohol or alcoholism (Laukka et al, 1997;Krause et al, 2002;Suresh et al, in preparation (a) and Suresh et al in preparation (b)). There is also a paucity of research examining oscillatory neural correlates of response inhibition using Goy No-Go paradigms (Shibata et al, 1997(Shibata et al, , 1998.…”

Section: Introductionmentioning

confidence: 99%

“…They found that alcohol significantly increased theta activity while the subjects were performing an attentional motor task of simulated automobile driving. Using the event-related desynchronizationysynchronization (ERDyERS), a methodology first described by Pfurtscheller and Aranibar (1977), Krause et al (2002) examined the effects of alcohol on ERDyERS during an auditory memory task, and found that the administration of alcohol decreased the early-appearing ERS responses during auditory encoding and increased the later-appearing ERD responses during retrieval. Alcohol had significant effects on brain electric oscillatory systems in the theta frequency range during both memory encoding and retrieval as well as in the lower alpha frequency range during cognitive processing.…”

Section: Introductionmentioning

confidence: 99%

The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism

Kamarajan

Porjesz

Jones

et al. 2004

International Journal of Psychophysiology

149

148

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Event-related oscillations play a key role in understanding the brain dynamics and human information processing. In the present study, the Go/No-Go paradigm has been used to examine whether alcoholics have poor inhibitory control as compared to control subjects in terms of different oscillatory brain responses. The matching pursuit algorithm was used to decompose the event-related electroencephalogram into oscillations of different frequencies. It was found that alcoholics (n=58) showed significant reduction in delta (1.0-3.0 Hz) and theta (3.5-7.0 Hz) power during No-Go trials as compared to controls (n=29). This reduction was prominent at the frontal region. The decreased delta and theta power associated with No-Go processing perhaps suggests a deficient inhibitory control and information-processing mechanism. A neuro-cognitive model has been provided to explain the findings. It is suggested that the oscillatory correlates during cognitive processing can be an endophenotypic marker in alcoholism.

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Alcohol-induced alterations in ERD/ERS during an auditory memory task

Cited by 20 publications

References 45 publications

Understanding alcohol use disorders with neuroelectrophysiology

Understanding alcohol use disorders with neuroelectrophysiology

Event-Related Theta Power during Lexical-Semantic Retrieval and Decision Conflict is Modulated by Alcohol Intoxication: Anatomically Constrained MEG

The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism

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