Alcohol induced impairment/abnormalities in brain: Role of MicroRNAs

Sushma, .; Divakar, Aman; Kanchan, Sonam; Jha, Gaurav; Mishra, Sakshi; Sharma, Dimple; Rath, Srikanta Kumar

doi:10.1016/j.neuro.2021.08.013

Cited by 9 publications

(3 citation statements)

References 186 publications

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“…miRNAs are also involved in microglial function ( Butovsky and Weiner, 2018 ; Cheray and Joseph, 2018 ; Guo et al, 2019 ; Qiu M. et al, 2021 ; Zhao et al, 2021 ). The expression of these miRNAs is epigenetically regulated by prenatal exposure ( Knopik et al, 2019 ; Sushma et al, 2021 ). Prenatal cocaine exposure (PCE) dysregulates DNA methylation and the expression of miRNAs that are important for the neurodevelopment of offspring ( Lambert and Bauer, 2012 ; Richardson et al, 2015 ; Vaillancourt et al, 2017 ).…”

Section: Mir124 and Mir153mentioning

confidence: 99%

Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective

Komada

Nishimura

2022

Front. Cell Dev. Biol.

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Neuroinflammation is a cause of neurodevelopmental disorders such as autism spectrum disorders, fetal alcohol syndrome, and cerebral palsy. Converging lines of evidence from basic and clinical sciences suggest that dysregulation of the epigenetic landscape, including DNA methylation and miRNA expression, is associated with neuroinflammation. Genetic and environmental factors can affect the interaction between epigenetics and neuroinflammation, which may cause neurodevelopmental disorders. In this minireview, we focus on neuroinflammation that might be mediated by epigenetic dysregulation in microglia, and compare studies using mammals and zebrafish.

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Section: Mir124 and Mir153mentioning

confidence: 99%

Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective

Komada

Nishimura

2022

Front. Cell Dev. Biol.

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“…Alcohol is a commonly consumed substance that can pose detrimental effects on the structure, physiology, and function of the central nervous system (CNS) (Patel & Mandal, 2018; Squeglia et al, 2014). Immature neurons are especially vulnerable to alcohol neurotoxicity.…”

Section: Introductionmentioning

confidence: 99%

“…Alcohol-induced neurodegeneration may be mediated by multiple cellular and molecular mechanisms, including neuroinflammation (Crews et al, 2017), oxidative stress (Hernández et al, 2016), autophagy (Luo, 2014), disruption of neurotrophic factor functions (Boschen & Klintsova, 2017), and dysregulation of microRNA (Divakar et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Upregulation of mesencephalic astrocyte‐derived neurotrophic factor (MANF) expression offers protection against alcohol neurotoxicity

Wen

Wang

et al. 2023

Journal of Neurochemistry

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Alcohol exposure has detrimental effects on both the developing and mature brain. Endoplasmic reticulum (ER) stress is one of the mechanisms that contributes to alcohol‐induced neuronal damages. Mesencephalic astrocyte‐derived neurotrophic factor (MANF) is an ER stress‐responsive protein and is neuroprotective in multiple neuronal injury and neurodegenerative disease models. MANF deficiency has been shown to exacerbate alcohol‐induced ER stress and neurodegeneration. However, it is unknown whether MANF supplement is sufficient to protect against alcohol neurotoxicity. Alcohol alters MANF expression in the brain, but the mechanisms underlying alcohol modulation of MANF expression remain unclear. This study was designed to determine how alcohol alters MANF expression in neuronal cells and whether exogeneous MANF can alleviate alcohol neurotoxicity. We showed that alcohol increased MANF transcription and secretion without affecting MANF mRNA stability and protein degradation. ER stress was necessary for alcohol‐induced MANF upregulation, as pharmacological inhibition of ER stress by 4‐PBA diminished alcohol‐induced MANF expression. In addition, the presence of ER stress response element II (ERSE‐II) was required for alcohol‐stimulated MANF transcription. Mutations or deletion of this sequence abolished alcohol‐regulated transcriptional activity. We generated MANF knockout (KO) neuronal cells using CRISPR/Cas9. MANF KO cells exhibited increased unfolded protein response (UPR) and were more susceptible to alcohol‐induced cell death. On the other hand, MANF upregulation by the addition of recombinant MANF protein or adenovirus gene transduction protected neuronal cells against alcohol‐induced cell death. Further studies using early postnatal mouse pups demonstrated that enhanced MANF expression in the brain by intracerebroventricular (ICV) injection of MANF adeno‐associated viruses ameliorated alcohol‐induced cell death. Thus, alcohol increased MANF expression through inducing ER stress, which could be a protective response. Exogenous MANF was able to protect against alcohol‐induced neurodegeneration.image

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The Alcohol Exposome

Sabet,

Wyatt

2024

Alcohol

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Alcohol induced impairment/abnormalities in brain: Role of MicroRNAs

Cited by 9 publications

References 186 publications

Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective

Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective

Upregulation of mesencephalic astrocyte‐derived neurotrophic factor (MANF) expression offers protection against alcohol neurotoxicity

The Alcohol Exposome

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