Alcohol-Induced Up-Regulation of Fibrinolytic Activity and Plasminogen Activators in Human Monocytes

Tabengwa, Edlue M.; Wheeler, Crystal G.; Yancey, Dwana A.; Grenett, Hernan E.; Booyse, François M.

doi:10.1097/00000374-200208000-00001

Cited by 8 publications

(8 citation statements)

References 38 publications

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“…The mechanism of potential protection against DVT remains unclear, though direct and transcriptional effects on endothelial function, platelet aggregation, fibrinolysis, tPA and PAI-1 have all been proposed [8,17,[22][23][24][25][26][27][28][29]. The transcriptional effects of ethanol intoxication may explain why we observed a lower DVT incidence in the EtOH group long after blood alcohol levels returned to normal.…”

Section: Discussionmentioning

confidence: 75%

Positive blood alcohol is associated with reduced DVT in trauma

Cook

Louis

McCully

et al. 2015

Injury

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Section: Discussionmentioning

confidence: 75%

Positive blood alcohol is associated with reduced DVT in trauma

Cook

Louis

McCully

et al. 2015

Injury

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“…For example, alcohol has been shown to increase tissue plasminogen activator secretion in cultured bovine endothelial cells 23. It has also been shown that alcohol has the ability to exert a direct and sustained effect on surface‐localized monocyte fibrinolytic activity in vitro 24. On the other hand, plasminogen activator inhibitor‐1, a major inhibitor of both tissue‐type and urokinase‐type plasminogen activators, is known to be upregulated in mild alcoholic liver injuries, whereas hyperfibrinolysis is common in more advanced alcoholic liver cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

A search for novel markers of alcohol abuse using magnetic beads and MALDI‐TOF/TOF mass spectrometry

Sogawa

Satoh

Kodera

et al. 2009

Proteomics Clinical Apps

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Objective markers are required to assess excessive alcohol consumption, which can lead to a various medical and social problems. In this study, we carried out serum peptidome analyses using the ClinProt(™) system, which consists of magnetic beads and MALDI-TOF/TOF MS, to find novel biomarkers of alcohol abuse in 16 chronic alcoholic patients that were hospitalized for a rehabilitation program. A total of 22 peaks were found to be significantly altered during abstinence. Out of these 22 peaks, 3 peaks that had an m/z of 3000 or less and substantial peak intensities were subjected to MS/MS analysis followed by a MASCOT search. The 1466 Da and the 1616 Da peptides were upregulated on admission and were identified as fragments of fibrinopeptide A and phosphorylated fibrinopeptide A, respectively. On the other hand, the 2660 Da peptide, which was downregulated on admission and increased during abstinence, was identified as a fragment of the fibrinogen α C chain. These peaks were not detectable by the SELDI-TOF MS ProteinChip(®) system analysis. The alterations in these peaks induced by alcohol abuse were also seen in γ glutamyltransferase nonresponders. These protein fragments may be additional biomarkers for excessive alcohol drinking.

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“…This directed us towards milder conditions for the reduction reaction with a simple work up procedure. We dissolved the ethanethiol esters in acetone at room temperature and treated them with triethylsilane in presence of catalytic 10% Pd/C to convert the thioester functionality into an aldehyde [ 27 ]. The reactions were allowed to proceed for two hours.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Triamino Acid Building Blocks with Different Lipophilicities

2015

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To obtain different amino acids with varying lipophilicity and that can carry up to three positive charges we have developed a number of new triamino acid building blocks. One set of building blocks was achieved by aminoethyl extension, via reductive amination, of the side chain of ortnithine, diaminopropanoic and diaminobutanoic acid. A second set of triamino acids with the aminoethyl extension having hydrocarbon side chains was synthesized from diaminobutanoic acid. The aldehydes needed for the extension by reductive amination were synthesized from the corresponding Fmoc-L-2-amino fatty acids in two steps. Reductive amination of these compounds with Boc-L-Dab-OH gave the C4-C8 alkyl-branched triamino acids. All triamino acids were subsequently Boc-protected at the formed secondary amine to make the monomers appropriate for the N-terminus position when performing Fmoc-based solid-phase peptide synthesis.

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Alcohol-Induced Up-Regulation of Fibrinolytic Activity and Plasminogen Activators in Human Monocytes

Cited by 8 publications

References 38 publications

Positive blood alcohol is associated with reduced DVT in trauma

Positive blood alcohol is associated with reduced DVT in trauma

A search for novel markers of alcohol abuse using magnetic beads and MALDI‐TOF/TOF mass spectrometry

Synthesis of Triamino Acid Building Blocks with Different Lipophilicities

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