Alcohol intake and cigarette smoking: Impact of two major lifestyle factors on male fertility

Gaur, Dushyant Singh; Talekar, Manju S; Pathak, V. P.

doi:10.4103/0377-4929.59180

Cited by 177 publications

(104 citation statements)

References 2 publications

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“…Studies on both human and animal laboratories have scientifically demonstrated that alcohol consumption impaired hypothalamic-pituitarygonadal (HPG) axis (Little et al, 1992;Maneesh et al, 2006), reduced testosterone level in the testes (Muthusami & Chinnaswamy, 2005) and diminished sperm quality. The sperm quality that are tremendously affected include, sperm concentration (Martini et al, 2004;Condorelli et al, 2014), morphological abnormalities (Joo et al, 2012) and sperm motility (Gaur et al, 2010). These finding were reported contrarily across other studies where they find no association between alcohol consumption and sperm quality (Kunzle et al, 2003;Teijon et al, 2007;Li et al, 2009;Hansen et al, 2012;Povey et al, 2012;Jensen et al, 2014).…”

Section: Introductioncontrasting

confidence: 45%

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Jaafar¹,

Osman²,

Kumar³

et al. 2017

JAS

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There is no solid conclusion on the conventional sperm parameters in association with alcohol consumption, evaluation of sperm DNA integrity thus become a more reliable parameter. Hereby, this literature search was performed to summarize alcohol consumption on the sperm DNA integrity. A computerized database search was done through MEDLINE via Ovid (since 1946 until August 2017) and Cochrane was used. The following set of keywords: 'alcohol consumption OR alcohol intake OR alcohol diet OR drinking alcohol OR ethanol diet' AND 'sperm DNA OR sperm chromatin OR sperm genome OR sperm histone OR sperm protamine' were utilised. 24 articles were retrieved where only five studies conform to the inclusion criteria All studies demonstrated a negative effect of alcohol consumption on sperm DNA integrity, regardless of various range of alcohol doses and duration of alcohol consumption. Out of five studies reviewed, four studies were using a different approach to measure the sperm DNA damage. Hereby, this review identified a need to use a single approach of DNA damage test by having various method of alcohol administration and/or vice versa so that the extension of sperm DNA damage to alcohol consumption will have a better conclusion. On the same note, a few studies have reported the reversibility on conventional semen parameters, none has been done on the sperm DNA damage upon alcohol withdrawal. Therefore, the role of alcohol withdrawal on the reversibility of sperm DNA damage needs to be as well investigated further.

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Section: Introductioncontrasting

confidence: 45%

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Jaafar¹,

Osman²,

Kumar³

et al. 2017

JAS

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“…Alcohol causes impaired testosterone production and thereby has great impact on fertility and potency. It also has deleterious effect on sertoli cells, thereby decreasing LH, FSH production [19], [20]. Spermatogenesis is sensitive to a variety of chemical and physical stressors.…”

Section: Discussionmentioning

confidence: 99%

Abnormalities in Semen Parameters of Men Due to Consumption of Alcohol

2016

IJSR

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Abstract:To investigate the effects of alcohol consumption on semen parameters, semen samples were collected from eighty (80) alcohol consumption men. This sample was from a cross section of population of Anantapuramu district, Andhra Pradesh, India. They were divided into two age groups namely 25-35 years and 35-45 years. In both age groups persons were selected basing as how many units of alcohol they consumed in a day. Different semen parameters like volume, liquefaction, alkalinity, sperm count, motility and morphology were analysed. Incidences of Hypospermia in 43, Teratozoospermia in 21, Oligozoospermia in 59, Oligoasthenozoospermia in 22 and Oligoasthenoteratozoopermia in 6 persons were observed. Abnormalities were seen in both age groups and was more pronounced in persons who consumed alcohol either moderately or heavily.

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“…Similar study by Gaur et al on 100 alcoholic showed oligozoospermia was much higher amongst alcohol cases (n=51), than controls, indicating progressive damage to testes in direct relation to increasing daily alcohol intake. 11 These studies showed lesser association of asthenozoospermia as compared to oligozoospermia. Thus, alcohol induced reduction in levels of testosterone, LH and FSH not only hamper their normal morphological development and maturation of spermatozoa, it slows down the sperm production by testicular germ cells, especially in alcoholic.…”

Section: Aswal a Et Al Int J Reprod Contracept Obstet Gynecol 2017 mentioning

confidence: 99%

“…Our results corroborated well with other studies like ones by Gaur et al, Khushbu et al and Kumar et al (Table 6). 10,11,14 Hence it is evident that alcohol consumption, tobacco smoking and tobacco chewing have a significant negative effect on the process of spermatogenesis, ultimately affecting sperm concentration, viability and motility. Hence clinician and fertility counselors need to be more focused to control infertility by modifying the life style factors.…”

mentioning

confidence: 99%

To analyse the semen for various parameters with special reference to lifestyle factors

Aswal

Sharma

Bansal

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Male factor is responsible for infertility in 23% cases. Semen analysis is the cornerstone of infertility evaluation as it provides information on the functional status of seminiferous tubules, epididymis and accessory sex glands. Reports in recent years has shown that incidence of male infertility has increased as a result of various factors such as lifestyle, environmental pollution and stress.Methods: This prospective study was conducted on patients reporting for semen analysis in Department of Pathology, Subharti Medical College. The duration of the study was from October 2014 to September 2016 with a study sample of 196 cases. Semen analysis was done by manual method according to WHO 2010 criteria.Results: According to fertility scoring, out of 196 cases, 51 (26%) were infertile cases. With respect to infertile cases 82.4% were alcoholic, 80.4% tobacco smokers, 25.5% were tobacco chewers. These results were statistically significant. Out of 45 cases of oligozoospermia 37 (82.2%) were alcoholic, 36 (80%) were tobacco smoker and 10 (22.2%) were tobacco chewers. Out of 54 cases of asthenozoosperma 38 (70.4%) were alcoholic, 37 (68.5%) were tobacco smoker and 11 (20.4%) were tobacco chewers.Conclusions: Alcohol consumption, tobacco smoking and tobacco chewing have a significant negative effect on the process of spermatogenesis, ultimately affecting sperm concentration, viability and motility. Hence clinician and fertility counselors need to be more focused to control infertility by modifying the life style factors.

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Alcohol intake and cigarette smoking: Impact of two major lifestyle factors on male fertility

Cited by 177 publications

References 2 publications

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Abnormalities in Semen Parameters of Men Due to Consumption of Alcohol

To analyse the semen for various parameters with special reference to lifestyle factors

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