Alcohol intake and incidence of type 2 diabetes in men.

Mao, Wei; Gibbons, Larry W.; Mitchell, Tedd L.; Kampert, James B.; Blair, Steven N.

doi:10.2337/diacare.23.1.18

Cited by 214 publications

(164 citation statements)

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“…Fasting hyperglycemia was found in 3160 men (11.0% of men; currently taking drugs for DM: 1.8%, fasting plasma glucose Z7.0 mmol/l: 2.6%; fasting plasma glucose 6.1-6.9 mmol/l: 6.6%) and 2725 women (8.3% of women; currently taking drugs for DM: 1.9%, fasting plasma glucose Z7.0 mmol/l: 2.0%; fasting plasma glucose 6.1-6.9 mmol/l: 4.4%). The mean BMI, WHR, and WC for men were 23 20 3.5% of men and 3.3% of women were obese (Z30) and 29.7% of men and 18.0% of women were overweight (Z25). Using the WHO cutoffs for WHR, 20 2.1% of men (Z1.0) and 12.5% of women (Z0.85) had central obesity.…”

Section: Resultsmentioning

confidence: 99%

“…16 Several studies in the US and England have indicated that smoking and alcohol consumption are associated with diabetes. [23][24][25] Smoking and drinking may increase the risk of diabetes through their effects on obesity or through physiological factors. 26,27 Few studies have compared the degree of association of BMI, WC, and WHR with hyperglycemia after adjustment for age and the use of cigarettes and alcohol.…”

Section: Introductionmentioning

confidence: 99%

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Association between indices of obesity and fasting hyperglycemia in Taiwan

Chien¹,

Liou

Chen

2004

Int J Obes

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OBJECTIVE:To examine the association of body mass index (BMI), waist-hip ratio (WHR), and waist circumference (WC) with fasting hyperglycemia after adjustment for age, cigarette smoking, and alcohol use. DESIGN: A cross-sectional survey was conducted among individuals visiting four health-screening centers across Taiwan. SUBJECTS: A total of 61 568 subjects (28 734 men and 32 834 women) between 25 and 64 years of age were included. Fasting hyperglycemia was defined as fasting plasma glucose Z6.1 mmol/l or current diagnosis and use of insulin or hypoglycemic agent. RESULTS: Fasting hyperglycemia was found in 11.0% of men and 8.3% of women. The factors significantly associated with fasting hyperglycemia in men were age, BMI, WHR, and heavy drinking, while for women these factors were age, educational level, BMI, WHR, and heavy smoking. For men, increased risk of fasting hyperglycemia started from age 30 to 34 years, BMI Z25 kg/m 2 , and WHR Z0.82. For women, increased risk of fasting hyperglycemia started from age 35 to 39 years, BMI Z24 kg/ m 2 , and WHR Z0.74. WC lost its significance as a predictor of fasting hyperglycemia when WHR included in the model. CONCLUSION: This study found that central obesity and general obesity were both independently associated with increased risk of fasting hyperglycemia in Taiwanese. The relationship between fasting hyperglycemia and central fat accumulation (WHR) begins to appear at levels that would not be regarded as representing obesity in Western populations, suggesting the need to redefine cutoffs for central obesity in this population.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between indices of obesity and fasting hyperglycemia in Taiwan

Chien¹,

Liou

Chen

2004

Int J Obes

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“…Although there have been no prospective studies evaluating the effect of long-term alcohol use on insulin sensitivity, per se, there have been a number of studies investigating whether there is any association between alcohol use at baseline and subsequent incidence of type 2 diabetes. Many of these studies found that light (ϳ3-18 g/day) (11)(12)(13) to moderate (18 -49 g/day) (14 -16) alcohol use was associated with a reduced risk for the development of diabetes. Two of these studies (11,13) were hampered due to the very limited number of subjects with moderate to heavy intake (i.e., Ͼ20 g/day, equivalent to more than two standard drinks per day).…”

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confidence: 99%

The Effect of Alcohol Intake on Insulin Sensitivity in Men

et al. 2003

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OBJECTIVE -Population data suggest that alcohol consumption may influence the risk of diabetes in a biphasic manner, but this has not been tested by any controlled interventions. The object of this study was to determine whether reducing alcohol intake in moderate-to-heavy drinkers (40 -110 g/day) results in improvement in insulin sensitivity. RESEARCH DESIGN AND METHODS-A 4-week run-in period where subjects maintained their usual drinking pattern was followed by randomization to a two-way cross-over intervention study. In each of two 4-week treatment interventions, subjects either substituted their usual alcohol intake with a 0.9% alcohol beer or maintained their usual alcohol intake. At the end of each 4-week period, insulin sensitivity as determined by the low-dose insulin glucose infusion test and the homeostasis model assessment (HOMA) score, and biomarkers of alcohol consumption (␥-glutamyl transpeptidase [␥-GT] and HDL cholesterol) were measured.RESULTS -A total of 16 healthy men aged 51.0 Ϯ 2.7 (mean Ϯ SEM) years with a BMI of 26.4 Ϯ 0.61 kg/m 2 completed the study. There was a large reduction in alcohol intake (72.4 Ϯ 5.0 vs. 7.9 Ϯ 1.6 g/day, P Ͻ 0.001) and significant reductions in ␥-GT (geometric mean .2], P Ͻ 0.01) and HDL cholesterol (1.36 Ϯ 0.07 vs. 1.13 Ϯ 0.07 mmol/l, P Ͻ 0.001). There was no effect of alcohol on insulin sensitivity index (ISI), fasting insulin, glucose, or HOMA score.CONCLUSIONS -A substantial reduction in alcohol intake from 7.2 to 0.8 standard drinks per day in healthy men did not change insulin sensitivity as measured by ISI or HOMA score. Diabetes Care 26:608 -612, 2003P resently, it is difficult to simply define overall effects of alcohol on the insulin-glucose axis. Acutely, alcohol impairs insulin sensitivity in shortterm experiments using insulin-glucose clamp techniques (1-5). In contrast, evidence from cross-sectional populationbased studies suggests an association between chronic alcohol exposure and improvement in insulin sensitivity (6), but such studies are rendered inherently weak by the potential for confounding by other variables affecting insulin sensitivity, especially adiposity (7-10). Although there have been no prospective studies evaluating the effect of long-term alcohol use on insulin sensitivity, per se, there have been a number of studies investigating whether there is any association between alcohol use at baseline and subsequent incidence of type 2 diabetes. Many of these studies found that light (ϳ3-18 g/day) (11-13) to moderate (18 -49 g/day) (14 -16) alcohol use was associated with a reduced risk for the development of diabetes. Two of these studies (11,13) were hampered due to the very limited number of subjects with moderate to heavy intake (i.e., Ͼ20 g/day, equivalent to more than two standard drinks per day). In the prospective Rancho Bernardo Study (17), the upper tertile of drinkers consumed Ͼ25 g alcohol/day, whereas in the Atherosclerosis Risk in Communities (ARIC) Study (18), Ͼ8% of the male population consumed Ͼ36 g alcohol/day. Data from...

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“…The meta-analysis done by Landol J Koppes 11 suggested that there is no reduction in the risk of Diabetes mellitus in heavy drinkers. Some of the studies have shown a non-linear relationship, [11][12][13][14] suggesting that moderate alcohol consumers may have reduced risk of Type-II DM as compared to the abstainers. However, even these studies agree that high alcohol consumption may increase the risk of Type-II DM.…”

Section: Resultsmentioning

confidence: 99%

Risk of type II diabetes mellitus in alcoholics: A hospital based cross-sectional study

2020

IJCAP

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Introduction: The rise in prevalence of diabetes in developing countries is due to industrialization, socioeconomic development, urbanization and changing life style. One of the important causes is the excessive intake of alcohol. In Sikkim, nearly 35% of the population of > 21yrs of age is chronic alcoholic which is a much higher figure as compared to the national average. 2 As per data compiled by Health Ministry, the prevalence of Type II Diabetes Mellitus (Type-II DM) was highest in Sikkim. The present study will be to assess the burden of Type II Diabetes Mellitus (DM) among alcoholics and to see the co-relation of DM and alcohol drinking pattern in the study population from Gangtok, Sikkim. Objective: To assess the burden of Type II Diabetes Mellitus(DM) among alcoholics, to see the co-relation of DM and alcohol drinking pattern and to see the lipid profile of the study participants. Materials and Methods: This cross-sectional hospital based study was undertaken in Central Referral Hospital, a tertiary care centre under Sikkim Manipal Institute of Medical Sciences Tadong, Gangtok. A hundred patients above 30 years of age admitted in the Central Referral Hospital and diagnosed as alcoholic liver disease during the period 01-07-2012 to 31-12-2012 were selected for the study. After taking a written informed consent, these patients were interviewed. Fasting and postprandial blood sugar, lipid profile and blood pressure were recorded from the case records. The collected data was analysed using INSTAT version 3 graph pad. The result is represented in tables. p<0.05 is considered significant. Results: The occurrence of Diabetes in relation to number of drinks per week was found to be statistically significant (p<0.05). On assessing lipid profile of study participants, it was found that the mean cholesterol, triglycerides and high density lipoproteins were significantly different in alcoholic diabetics and alcoholic nondiabetics. Conclusion: A definite association between alcohol consumption and Type II Diabetes Mellitus could not be established. However, there certainly appears to be some association between heavy alcohol consumption and Type-II DM. A reduction in alcohol intake by heavy drinkers may reduce their risk of developing Type-II DM.

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Alcohol intake and incidence of type 2 diabetes in men.

Cited by 214 publications

References 5 publications

Association between indices of obesity and fasting hyperglycemia in Taiwan

Association between indices of obesity and fasting hyperglycemia in Taiwan

The Effect of Alcohol Intake on Insulin Sensitivity in Men

Risk of type II diabetes mellitus in alcoholics: A hospital based cross-sectional study

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