Alcohol Intake and Risk of Incident Psoriasis in US Women

Qureshi, Abrar A.; Dominguez, Patrick; Choi, Hyon K.; Han, Jiali; Curhan, Gary C.

doi:10.1001/archdermatol.2010.204

Cited by 97 publications

(94 citation statements)

References 29 publications

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“…After multivariate adjustment, a recently published study in female US nurses showed a non-statistically significant increased risk of psoriasis to the subgroup having low dietary folate equivalent (DFE) intake among those drinking over 5 nonlight beers per week as compared to the high DFE group in this study. The median intake was 976 ug in this study from 1991-2002 and 1000 ug in the 2003-2006 period [41]. Both groups however include DFEs at or near the 1000-2000 ug daily dose range where folate in our cases seems to flare psoriasis.…”

Section: Commentmentioning

confidence: 52%

Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

Aronson¹

2017

J Transl Sci

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The daily intake of FA of 5% Americans age 50 and over and in one study of psoriatic American women is about 1 mg. A patient with plaque psoriasis on 10 mg lisinopril did not improve on vitamins B12 and B6 alone. When folic acid 5 mg daily was added PASI improved 50%. Three cases of plaque psoriasis flared when given 1-2 mg folic acid (FA), 100 mg vitamin B6 and 1000 mcg daily B12. When daily FA was increased to 4 to 7 mg daily all three cases improved their disease.

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Section: Commentmentioning

confidence: 52%

Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid

Aronson¹

2017

J Transl Sci

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“…29 Most recently, Qureshi et al prospectively evaluated the association between total alcohol consumption and risk of incident psoriasis in a cohort of 82,869 nurses with no history of psoriasis. 30 Compared with women who did not drink alcohol, the multivariate relative risk of psoriasis was 1.72 for an alcohol consumption of 2.3 drinks per week or more. When examined by type of alcoholic beverage, there was an association between psoriasis and non-light beer intake.…”

Section: Risk Factorsmentioning

confidence: 94%

Psoriasis: epidemiology, natural history, and differential diagnosis

Basko-Plluska¹,

Petronic‐Rosic²

2012

PTT

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Psoriasis is a chronic, immune-mediated, inflammatory disease which affects primarily the skin and joints. It occurs worldwide, but its prevalence varies considerably between different regions of the world. Genetic susceptibility as well as environmental factors play an important role in determining the development and prognosis of psoriasis. Genomewide association studies have identified many genetic loci as potential psoriasis susceptibility regions, including PSORS1 through PSORS7. Histocompatibility antigen (HLA) studies have also identified several HLA antigens, with HLA-Cw6 being the most frequently associated antigen. Epidemiological studies identified several modifiable risk factors that may predispose individuals to developing psoriasis or exacerbate pre-existing disease. These include smoking, obesity, alcohol consumption, diet, infections, medications and stressful life events. The exact mechanism by which they trigger psoriasis remains to be elucidated; however, existing data suggest that they are linked through Th1-mediated immunological pathways. The natural history of psoriasis varies depending on the clinical subtype as well as special circumstances, including pregnancy and HIV infection. In general, psoriasis is a chronic disease with intermittent remissions and exacerbations. The differential diagnosis is vast and includes many other immunemediated, inflammatory disorders.

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“…In fact, consuming more than 2-3 alcoholic drinks per week significantly increases the risk of psoriasis, 34,35 and more than 100 g/d in men is a risk factor for increased activity of psoriasis. 36 Other authors found no association between alcohol consumption and severity of psoriasis. The fact that we took a clinical history could have influenced the levels of alcohol consumption reported by the patients.…”

Section: Discussionmentioning

confidence: 95%