Alcohol Intake During Pregnancy and Offspring's Atopic Eczema Risk

Abstract

Alcohol consumption during pregnancy might have an effect on developing atopic eczema in offspring.

In utero alcohol effects on foetal, neonatal and childhood lung disease

“…In a recent report evaluating a Japanese cohort, maternal alcohol intake during pregnancy significantly increased the risk of atopic eczema before age 3 and before age 5. 49 These data are in agreement with other authors, who demonstrated an increased risk of atopic dermatitis in early infancy 50 and during the first 7 years of life in alcohol-exposed offspring. 51 Nevertheless, the data on foetal alcohol’s effect on the development of asthma is less convincing.…”

“…In the Japanese cohort, offspring exposed to maternal alcohol demonstrated a 2 fold, albeit non-significant (p=0.058) increased risk of asthma before age 3, suggesting further studies are warranted. 49 However, in a large Norwegian cohort, maternal alcohol use during pregnancy had no significant effect on asthma at age 3 or age 7, 52 while a study of newborns in Copenhagen demonstrated no effects of alcohol exposure on infant lung function testing at one month of age. 53 …”

Adverse health outcomes associated with fetal alcohol exposure: A systematic review focused on immune‐related outcomes

“…Two older case‐control studies obtained the lowest scores, both with 8 out of a possible 19. In comparison, the highest score was obtained by Wada et al with 16 out of a possible 19. Items commonly insufficiently addressed included the following: reporting on the representativeness of study participants (items 11 and 12), mentioning if an attempt was made to blind those measuring the main outcomes (item 15), and including a power calculation to assess sample size validity for detecting a significant difference between PAE and control group, if it occurs (item 27).…”

“…Most recently, Carson et al analyzed data from the Copenhagen Study on Asthma in Childhood, which recruited children born to women with a history of asthma. The three remaining longitudinal studies were from Norway, the United Kingdom (UK), and Japan . The Norwegian study assessed outcomes from the Mother and Child Cohort Study, which recruited pregnant women and followed up children until 7 years of age.…”

“…The Norwegian study assessed outcomes from the Mother and Child Cohort Study, which recruited pregnant women and followed up children until 7 years of age. The Japanese study recruited women during pregnancy from a maternal clinic and followed up until children were 5 years old. The UK study examined outcomes from the Avon Longitudinal Study of Parents and Children, predominately Caucasian women from Bristol, UK.…”