Alcohol intake, specific alcoholic beverages, and risk of hip fractures in postmenopausal women and men age 50 and older

Abstract

Background Although a number of studies have examined the association between alcohol intake and hip fractures, few have considered specific alcoholic beverages separately. Objectives We prospectively assessed total alcohol and specific alcoholic beverage consumption and risk of hip fractures in US men and women. Methods Health, lifestyle information, and hip fractures were self-reported on biennial questionnaires between 1980 and 2014 in 75,180 postmenopausal women from the Nurses’ Health Study, and between 1986 and 2014 in 38,398 men aged ≥50 y from the Health Professionals Follow-Up Study. Diet was assessed approximately every 4 y with a semiquantitative FFQ. RRs were computed for hip fracture using Cox proportional hazards models, adjusting for potential confounders. Results We ascertained 2360 incident low trauma hip fractures in women and 709 in men. Among women, RRs for low trauma hip fractures compared with nondrinkers were 0.89 (95% CI: 0.80, 0.99) for an average daily consumption of <5.0 g, 0.81 (95% CI: 0.70, 0.94) for 5.0 to <10.0 g, 0.83 (95% CI: 0.71, 0.96) for 10.0 to <20.0 g, and 0.93 (95% CI: 0.78, 1.10) for ≥20.0 g. Among men, risk declined linearly with higher alcohol consumption (P-trend = 0.002). Multivariable RR compared with nondrinkers was 0.77 (95% CI: 0.59, 1.01), 0.69 (0.49, 0.96), and 0.67 (0.48, 0.95) for an average intake of 10 g/d to <20 g/d, 20 g/d to <30 g/d, and 30.0 g/d or more, respectively. In women, the alcoholic beverage most significantly associated with hip fracture risk was red wine (RR per serving = 0.59; 95% CI: 0.45, 0.79). In men, there was no clear association with specific alcoholic beverages. Conclusion In these 2 US cohorts, low to moderate alcohol consumption, when compared with no consumption, was associated with a lower risk of hip fractures, particularly with red wine consumption among women.

Alcohol Consumption, Bone Mineral Density, and Risk of Osteoporotic Fractures: A Dose–Response Meta-Analysis

“…Although the early paradigm associated with the Mediterranean diet identified moderate alcohol consumption, with red wine as an alcohol source, a growing body of literature shows that the relationship between alcoholic beverages and mortality is rather consistent for both wine and beer, resulting in reduced risk in moderate consumers compared to abstainers or heavy drinkers [44]. Moreover, the results from prospective cohorts suggest that moderate alcohol consumption is inversely associated with risk of hip fractures in middle-aged and older men and women [45]. It should be noted that, in addition to the alcoholic content, these beverages are characterized by a variety of bioactive compounds-mainly polyphenolswhich may explain, at least in part, the potential benefits for health [46].…”

Gender Differences in Personal and Situational Risk Factors for Traumatic Brain Injury Among Older Adults

“…Studies have shown that frequent or heavy alcohol use in older adults is either positively associated with or inversely associated with fall risks. [29][30][31][32] In this study, drinking alcohol 3 times or more per week was associated with TBI occurrence in men but not in women. The main reason for this result in women is that very few women frequently consumed alcohol, although women can have major physical factors (eg, less lean muscle mass) that make them particularly susceptible to the negative effects of increased alcohol consumption.…”

“…Studies have shown that frequent or heavy alcohol use in older adults is either positively associated with or inversely associated with fall risks 29–32. In this study, drinking alcohol 3 times or more per week was associated with TBI occurrence in men but not in women.…”

Epidemiological Comparison of Osteoporotic Hip Fractures in Spain and China: A Multicenter Study

“…Many studies have shown that alcohol affects bone metabolism, not only inhibits bone synthesis, but also increases bone resorption through direct and indirect pathways, leading to osteopenia and osteoporosis, thereby increasing the risk of fractures [24,25]. In our comparative study, we found that the proportion of Spanish women drinking is signi cantly higher than that of Chinese women.…”