Alcohol intolerance in neoplastic disease.

Brewin, T.B.

doi:10.1136/bmj.2.5511.437

Cited by 49 publications

(17 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 Preclinical manifestations of hematologic malignancies may cause subjects to either quit drinking or to continue their drinking on a lower level. 41 When using the baseline measurement of alcohol intake only, these individuals will be categorized as an abstainer or as a low level drinker. This will result in an underestimated disease risk.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and risk of lymphoid and myeloid neoplasms: Results of the Netherlands cohort study

Heinen

Verhage

Schouten

et al. 2013

Intl Journal of Cancer

View full text Add to dashboard Cite

Results from epidemiological studies suggest that alcohol drinkers have a decreased risk of lymphoid neoplasms, whereas results for myeloid neoplasms are inconsistent. However, most of these studies have used retrospective data. We examined prospectively whether alcohol consumption decreases the risk of both lymphoid and myeloid neoplasms, including most common subtypes. Moreover, we investigated whether this decreased risk is due to ethanol or other contents of specific alcoholic beverages (i.e., beer, wine and liquor). The Netherlands cohort study consisted of 120,852 individuals who completed a baseline questionnaire in 1986. After 17.3 years of follow-up, 1,375 cases of lymphoid and 245 cases of myeloid neoplasms with complete exposure information were available for analysis. Compared with abstinence, we observed for plasma cell neoplasms hazard rate ratios (HR) of 1.66 (95% confidence interval (CI), 1.21-2.29), 1.63 (95% CI, 1.17-2.27), 1.11 (95% CI, 0.75-1.64) and 0.85 (95% CI, 0.51-1.42) with daily ethanol consumption of 0.1-<5, 5-<15, 15-<30 and 30 g, respectively. A similar pattern was observed for chronic lymphocytic leukemia=small lymphocytic lymphoma. No associations were observed for other subtypes and for myeloid neoplasms. When results were analyzed by beverage type, no clear associations were observed. In conclusion, our study did not show an inverse association between alcohol consumption and lymphoid neoplasms. Also, no inverse association was observed with myeloid neoplasms. If any association between alcohol consumption and lymphoid neoplasms exists, our study suggests an increased risk rather than a decreased risk.Hematologic malignancies, a heterogeneous group of neoplasms arising in lymphoid and myeloid cells throughout the body, account for 7.4% of cancers in males and 6.4% in females worldwide. 1 So far, little is known about the causes of hematologic malignancies. A few factors have been linked to lymphoid neoplasms, including age, gender, primary=inherited immune deficiencies, a number of viruses including the human immunodeficiency virus and several autoimmune diseases. 2 Also for myeloid neoplasms just few etiologic factors have been identified so far, including age, gender, genetic abnormalities, family history and exposures to radiation and benzene. 3 There is some evidence indicating that distinguishing between subtypes of lymphoid and myeloid neoplasms may reveal etiological heterogeneity 4 and, therefore, further research including individual subtypes with sufficient numbers of these neoplasms is needed.Most studies about alcohol consumption and risk of hematologic malignancies concern non-Hodgkin lymphoma (NHL). Recently, a meta-analysis including 20 case-control studies, one pooled analysis of nine case-control studies and eight cohort studies showed a reduction in NHL risk in association with higher alcohol intake. 5 Compared with nondrinkers, the pooled relative risks (RRs) were 0.88 (95% confidence interval (CI), 0.81-0.96) for light drinking ( 1 drink per day) and 0.87 (95...

show abstract

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and risk of lymphoid and myeloid neoplasms: Results of the Netherlands cohort study

Heinen

Verhage

Schouten

et al. 2013

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…5 The exact mechanism is unknown, but it is hypothesized that a localized alcohol associated allergic response induces vasodilatation and swelling in the diseased tissue, activating nociceptive signals. 5,8 This may help explain the high correlation observed between the site of the pain and underlying disease. 3 Although it is difficult to establish an exact cause-andeffect relationship in our case, several features about our patient's episode led us to speculate that her symptom was propofol associated.…”

Section: To the Editormentioning

confidence: 99%

“…6 Women and those with nodular sclerosis subtype of HL are especially prone; the alcohol content of a liqueur-filled chocolate or even a sip of beer has been reported to trigger the pain. 3,5,7 The onset of pain is immediate; the patient descriptions of pain vary from "aching" to "stabbing," and the intensity ranges from mild to unbearable, forcing some patients to give up alcohol entirely. 5 The exact mechanism is unknown, but it is hypothesized that a localized alcohol associated allergic response induces vasodilatation and swelling in the diseased tissue, activating nociceptive signals.…”

Section: To the Editormentioning

confidence: 99%

“…3,5,7 The onset of pain is immediate; the patient descriptions of pain vary from "aching" to "stabbing," and the intensity ranges from mild to unbearable, forcing some patients to give up alcohol entirely. 5 The exact mechanism is unknown, but it is hypothesized that a localized alcohol associated allergic response induces vasodilatation and swelling in the diseased tissue, activating nociceptive signals. 5,8 This may help explain the high correlation observed between the site of the pain and underlying disease.…”

Section: To the Editormentioning

confidence: 99%

“…Association of pain with alcohol ingestion is well known and has been reported in the past, particularly in the oncology literature. [3][4][5] Alcohol-related pain has been classically associated with HL. The reported incidence of this disorder is approximately 3%.…”

Section: To the Editormentioning

confidence: 99%

See 2 more Smart Citations