Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-b]Pyridine from a One-Pot Three-Component Reaction

Abstract

A concise and efficient approach to synthesizing coumarin-fused pyrazolo[3,4-b]pyridine via silica sulfuric acid (SSA) catalyzed three-component domino reaction under microwave irradiation has been demonstrated. Participation of various alcohols in construction of coumarin derivatives has been described for the first time. Short reaction time, high yields, one-pot procedure, usage of eco-friendly catalyst, and solvent are the key features of this method.

Modern Strategies for Heterocycle Synthesis

“…This Special Issue presents three contributions of multicomponent reactions (MCRs), in which access to different molecular skeletons is realized. Participation of various alcohols in the construction of coumarin-fused pyrazolo [3,4-b]pyridines via a silica sulfuric acid (SSA)-catalyzed three-component domino reaction under microwave irradiation is presented for the first time by Lin, Wang and co-authors [11]. In another work, the group of Palacios and Vicario [12] reports a phosphoric acid-catalyzed MCR procedure for the synthesis of highly functionalized γ-lactam derivatives by the reaction of benzaldehyde, amines and acetylenedicarboxylate.…”