Background: The alcohol consumption level is rising in Burkina Faso, which has the highest prevalence of heavy drinking in West Africa. This study used daily alcohol intake levels to explore drinking behaviors in regard to the days of the week and associations with dependence signs.Methods: We operated variables from the past 12-month drinkers reported by the 2013 Stepwise survey, which provided information on daily drinking and symptoms of alcohol dependence. We performed student tests, principal component analyses and logistic regression.Results: Data from 1,139 past 12-month drinkers was analyzed, and 15.9% (95%; CI: 13.8–18.1) of users had at least one sign of alcohol dependence. Both drinkers without and with dependence symptoms had a common behavior for higher intake on Thursday, Saturday and Sunday, while lower intake behavior was observed on Tuesday. Only drinkers with dependence signs had high intake behavior, especially on Monday and Friday. In multivariate analysis, alcohol dependence signs were associated with increased drinking only on Monday [adjusted odds ratio (aOR) =1.24, p=0.0001)] or Friday (aOR=1.15, p=0.003).Conclusion: For drinkers without any dependence sympoms, behaviors for higher intake were limited to Thursday, Saturday and Sunday in accordance with the “social events schedule” and the “weekly administrative time-off”, but those with dependence signs extended this kind of behavior to Monday or Friday, likely due to the increased and persistent craving triggered by the high intake the previous day.