Alcohol, psychomotor-stimulants and behaviour: methodological considerations in preclinical models of early-life stress

Abstract

The standardisation of these simple stress procedures means that results will be more comparable between studies and that results generated will give us a more robust understanding of what can and may be happening in the human and veterinary clinic.

Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood

“…Animal models of PS have been designed to transfer the stress experienced by the mother to the embryo or fetus in utero by exposing the pregnant dam to stressors during different gestational phases (Huizink, Mulder et al 2004, Mastorci, Vicentini et al 2009, Bock, Wainstock et al 2015. Similarly, animal models of ELS have been designed to mimic childhood adversities, mostly related to the quality of maternal care such as maternal neglect or maltreatment (Jawahar, Murgatroyd et al 2015, McDonnell-Dowling andMiczek 2018).…”