Alcohol Reduces Cross‐Frequency Theta‐Phase Gamma‐Amplitude Coupling in Resting Electroencephalography

Lee, Jaewon; Yun, Kyongsik

doi:10.1111/acer.12310

Cited by 8 publications

(1 citation statement)

References 52 publications

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“…The rigid striatal-dependent performance was the most direct explanation for the reduction in memory flexibility after AA treatment (Wright et al, 2013; Abramson et al, 2015), so it would be of interest to determine if AA also affects the neural activities of other regions, such as that involved in reversal learning (Ragozzino, 2007). The decrease in cross-structure couplings could be thought of as an inhibitory effect of AA on synchronized oscillations (Lee and Yun, 2014) and functional connectivity in cortical activity (Levin et al, 1998; Meda et al, 2009). The high-frequency coupling has found to be involved in different implicit learning tasks (Wessel et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate of Learning Strategy by Inhibition of PKA/CREB Pathway in Rats

Sun

Tang

et al. 2018

Front. Pharmacol.

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The hippocampus and striatum guide place-strategy and response-strategy learning, respectively, and they have dissociable roles in memory systems, which could compensate in case of temporary or permanent damage. Although acute alcohol (AA) treatment had been shown to have adverse effects on hippocampal function, whether it causes the functional compensation and the underlying mechanisms is unknown. In this study, rats treated with a low dose of AA avoided a hippocampus-dependent spatial strategy, instead preferring a striatum-dependent response strategy. Consistently, the learning-induced increase in hippocampal, but not striatal, pCREB was rendered less pronounced due to diminished activity of pPKA, but not pERK or pCaMKII. As rats approached the turn-decision area, Sp-cAMP, a PKA activator, was found to mitigate the inhibitory effect of AA on intra- and cross-structure synchronized neuronal oscillations, and rescue response-strategy bias and spatial learning deficits. Our study provides strong evidence of the critical link between neural couplings and strategy selection. Moreover, the PKA/CREB-signaling pathway is involved in the suppressive effect of AA on neural correlates of place-learning strategy. The novel important evidence provided here shows the functional couplings between the hippocampus and striatum in spatial learning processing and suggests possible avenues for therapeutic intervention.

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Section: Discussionmentioning

confidence: 99%

Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate of Learning Strategy by Inhibition of PKA/CREB Pathway in Rats

Sun

Tang

et al. 2018

Front. Pharmacol.

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Acute ethanol and taurine intake affect absolute alpha power in frontal cortex before and after exercise

Paulucio

Costa²,

Santos

et al. 2017

Neuroscience Letters

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Taurine and alcohol has been popularly ingested through energy drinks. Reports from both compounds shows they are active on nervous system but little is known about the acute effect of these substances on the frontal cortex in an exercise approach. The aim of this study was to determine the effects of 0,6mldL of ethanol (ET), 6g of taurine (TA), and taurine with ethanol (TA+ET) intake on absolute alpha power (AAP) in the frontal region, before and after exercise. Nine participants were recruited, five women (22±3years) and four men (26±5years), for a counterbalanced experimental design. For each treatment, the tests were performed considering three moments: "baseline", "peak" and "post-exercise". In the placebo treatment (PL), the frontal areas showed AAP decrease at the post-exercise. However, in the TA, AAP decreased at peak and increased at post-exercise. In the ET treatment, AAP increased at the peak moment for the left frontal electrodes. In the TA+ET treatment, an AAP increase was observed at peak, and it continued after exercise ended. These substances were able to produce electrocortical activity changes in the frontal regions after a short duration and low intensity exercise. Left and right regions showed different AAP dynamics during peak and post-exercise moments when treatments were compared.

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A Systematic Review of the Balloon Analogue Risk Task (BART) in Alcohol Research

Canning

Schallert

Larimer

2021

Alcohol and Alcoholism

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Risk-taking propensity has been crucial to the investigation of alcohol use and consequences. One measure, the balloon analogue risk task (BART), has been used consistently over the past two decades. However, it is unclear how this measure is related to alcohol outcomes. This paper systematically reviews the literature on the BART and alcohol outcomes. First, direct associations between the BART and alcohol use are reviewed including correlations, group comparisons, the BART’s prediction of alcohol outcomes and BART performance after consuming alcohol. Then, potential moderators that explain when and for whom the BART is related to alcohol outcomes are reviewed. Finally, potential mechanisms that explain how the BART and alcohol outcomes are related are reviewed. This review reveals patterns in the BART suggesting risk-taking propensity may be related to changes in alcohol use over time; however, there is little evidence to suggest BART scores increase after consuming alcohol. Yet, additional research suggests adjusted average pump scores may be too simplistic for the amount of information the BART captures and understanding individual’s patterns of responses on the BART is important for investigating its relation to alcohol outcomes. Finally, this review opens up several future directions for research to understand how risk-taking propensity is related to alcohol outcomes.

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Alcohol Reduces Cross‐Frequency Theta‐Phase Gamma‐Amplitude Coupling in Resting Electroencephalography

Abstract: Our findings suggest that theta-phase gamma-amplitude coupling is deficiently synchronized at rest after alcohol ingestion. Therefore, cross-frequency coupling could be a useful tool for studying the effects of alcohol on the brain and investigating alcohol addiction.

Cited by 8 publications

References 52 publications

Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate of Learning Strategy by Inhibition of PKA/CREB Pathway in Rats

Acute Low Alcohol Disrupts Hippocampus-Striatum Neural Correlate of Learning Strategy by Inhibition of PKA/CREB Pathway in Rats

Acute ethanol and taurine intake affect absolute alpha power in frontal cortex before and after exercise

A Systematic Review of the Balloon Analogue Risk Task (BART) in Alcohol Research

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