Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble?

Munukutla, Srikar; Pan, Guodong; Deshpande, Mandar; Thandavarayan, Rajarajan Amirthalingam; Krishnamurthy, Prasanna; Palaniyandi, Suresh S.

doi:10.1111/acer.13008

Cited by 26 publications

(30 citation statements)

References 99 publications

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“…However, this interaction was not significantly related to incident retinopathy and nephropathy. Past research has shown that heavy alcohol use and high depressive symptoms are each independently positively related to neuropathy and heart disease . The present study adds to the literature by demonstrating that the combination of high depressive symptoms and high alcohol frequency may lead to an even greater risk of neuropathy and CAD.…”

Section: Discussionsupporting

confidence: 60%

“…Several possible mechanisms may link alcohol consumption to diabetes‐related complications . Whereas acute alcohol consumption may not have any significant long‐term effects on glucose in individuals with T2DM, chronic heavy alcohol use may result in changes in glucose levels, insulin resistance, changes in lipid levels, mitochondrial dysfunction, and interference in cell signalling .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, individuals with T2DM who drink heavily are also more likely to engage in poorer self‐management behaviors, including poorer medication adherence, diet, and exercise, than those who drink less . Through these metabolic, cell signaling, and self‐management changes, heavy alcohol use can increase the risk of complications …”

Section: Discussionmentioning

confidence: 99%

“…Alcohol use in individuals with T2DM is associated with macrovascular and microvascular complications, and these complications can contribute to morbidity and mortality in individuals with T2DM . Heavy alcohol use is associated with an increased risk of macrovascular complications, such as cardiovascular disease, whereas moderate alcohol use is associated with a decreased risk of cardiovascular disease …”

Section: Introductionmentioning

confidence: 99%

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Alcohol consumption, depressive symptoms, and the incidence of diabetes‐related complications

Elgendy

Deschênes

Burns

et al. 2018

Journal of Diabetes

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alcohol consumption, depressive symptoms, and the incidence of diabetes‐related complications

Elgendy

Deschênes

Burns

et al. 2018

Journal of Diabetes

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“…[3]. Among these factors, the associations between alcohol drinking and T2DM have been widely studied [4,5]. More alcohol consumption may relate to higher susceptibility to T2DM.…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy

et al. 2017

IJERPH

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Type 2 diabetic mellitus (T2DM) is a disease with high prevalence and a major cause for death worldwide. Diabetic retinopathy (DR) is one of the major manifestation of diabetes. Aldehyde dehydrogenease 2 (ALDH2) detoxifies aldehyde produced during ethanol metabolism and oxidative stress. It has been found that the polymorphism in ALDH2 rs671 is probably associated with the risk of T2DM and DR. However, a lot of inconsistency and controversy still exists. In order to get a more precise and comprehensive estimation for the association between ALDH2 polymorphism with the risk of T2DM and DR, we conducted the present meta-analysis. A comprehensive literature search was conducted using databases, such as Pubmed, Embase, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, and Chinese Biomedical Literature Database, for all related studies. The included studies met the inclusion criteria, such as being case-control studies about the association of ALDH2 polymorphism and T2DM or DR susceptibility, with sufficient data for the present analysis. Eight studies with 2374 cases and 6694 controls were involved in the present meta-analysis. The results indicated a significant lower risk of T2DM for *1/*1 genotype in homozygous models (*1/*1 vs. *2/*2, OR = 0.31, 95% CI = 0.11–0.89, p = 0.03) and in the dominant model (*1/*1 vs. *2/*2 + *1/*2, OR = 0.61, 95% CI = 0.37–1.00, p = 0.05). Subgroup analysis by ethnicity found a significant lower risk of T2DM in Chinese in all genotype models. No significant relation was found between ALDH2 rs671 and DR. In conclusion, the current meta-analysis indicated that ALDH2 rs671 was significantly related with T2DM. The ALDH2 rs671 might be able to be used as a predictor for the risk of T2DM. However, due to the existence of heterogeneity and publication bias in the involved studies, our results should be interpreted with caution.

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Alcohol‐induced increase in BMP levels promotes fatty liver disease in male prediabetic stage Otsuka Long‐Evans Tokushima Fatty rats

Hong

Kim

Son

et al. 2023

J of Cellular Biochemistry

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Alcohol consumption exacerbates liver abnormalities in animal models, but whether it increases the severity of liver disease in early diabetic or prediabetic rats is unclear. To investigate the molecular mechanisms underlying alcohol‐induced liver steatosis or hepatitis, we used a prediabetic animal model. Otsuka Long‐Evans Tokushima Fatty (OLETF) and Long‐Evans Tokushima Fatty (LETO) rats were pair‐fed with an ethanol‐containing liquid diet for 6 weeks. Compared with controls, OLETF and LETO rats displayed more pronounced liver steatosis and higher plasma levels of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamate pyruvate transaminase (SPGT), indicating liver injury. Ethanol‐fed LETO (Pd‐L‐E) rats showed mild liver steatosis and no inflammation compared with ethanol‐fed OLETF (Pd‐O‐E) rats. Although precursor and active SREBP‐1 levels in the liver of ethanol‐fed OLETF rats significantly increased compared with control diet‐fed OLETF rats (Pd‐O‐C), those of Pd‐L‐E rats did not. Bone morphogenetic protein (BMP) and TGF‐β1 balance in Pd‐O‐E rats was significantly altered because BMP signaling was upregulated by inducing BMP2, BMP4, BMP7, BMP9, Smad1, and Smad4, whereas TGF‐β1, Smad3, and Erk were downregulated. Activation of TGF‐β/Smad signaling inhibited BMP2 and BMP9 expression and increased epithelial‐mesenchymal transition (EMT) marker levels (Hepcidin, Snail, and Twist) in the liver of LETO rats. Livers of ethanol‐fed OLETF rats showed increased levels of vimentin, FSP‐1, α‐SMA, MMP1, MMP13, and collagen III compared with rats of other groups, whereas EMT marker levels did not change. Thus, BMP exerted anti‐ and/or pro‐fibrotic effects in ethanol‐fed rats. Therefore, BMP and TGF‐β, two key members of the TGF‐β superfamily, play important but diverse roles in liver steatosis in young LETO and OLETF rats.

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Alcohol Toxicity in Diabetes and Its Complications: A Double Trouble?

Abstract: This review summarizes the epidemiology, diagnosis, pathophysiology, metabolic, and cell signaling alterations and finally brushes upon issues and strategies to manage the "double trouble."

Cited by 26 publications

References 99 publications

Alcohol consumption, depressive symptoms, and the incidence of diabetes‐related complications

Alcohol consumption, depressive symptoms, and the incidence of diabetes‐related complications

Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy

Alcohol‐induced increase in BMP levels promotes fatty liver disease in male prediabetic stage Otsuka Long‐Evans Tokushima Fatty rats

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