Alcohol type and ideal cardiovascular health among adults of the Multi-Ethnic Study of Atherosclerosis

Ogunmoroti, Oluseye; Osibogun, Olatokunbo; McClelland, Robyn L.; Lazo, Mariana; Mathews, Lena; Okunrintemi, Victor; Oni, Ebenezer; Burke, Gregory L.; Michos, Erin D.

doi:10.1016/j.drugalcdep.2020.108358

Cited by 11 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given alcohol consumption is associated with CVH, participant alcohol use was included as an additional covariate in the current analyses. 18 SES has been associated with CVH. 19 Given the effect of adult income on the association observed between RF and CVH in a prior study, adult income was included as a covariate in the current analyses, 12 which in CARDIA, was measured as total combined family income over the last 12 months.…”

Section: Covariatesmentioning

confidence: 93%

Evidence for the Association Between Adverse Childhood Family Environment, Child Abuse, and Caregiver Warmth and Cardiovascular Health Across the Lifespan: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Ortiz,

Kershaw,

Zhao

et al. 2024

Circ: Cardiovascular Quality and Outcomes

View full text Add to dashboard Cite

Background: This study aimed to quantify the association between childhood family environment and longitudinal cardiovascular health (CVH) in adult CARDIA (Coronary Artery Risk Development in Young Adults) Study participants. We further investigated whether the association differs by adult income. Methods: We applied the CVH framework from the American Heart Association including metrics for smoking, cholesterol, blood pressure, glucose, body mass index, physical activity, and diet. CVH scores (range, 0–14) were calculated at years 0, 7, and 20 of the study. Risky Family environment (range, 7–28) was assessed at year 15 retrospectively, for childhood experiences of abuse, caregiver warmth, and family or household challenges. Complete case ordinal logistic regression and mixed models associated risky family (exposure) with CVH (outcome), adjusting for age, sex, race, and alcohol use. Results: The sample (n=2074) had a mean age of 25.3 (±3.5) years and 56% females at baseline. The median risky family was 10 with ideal CVH (≥12) met by 288 individuals at baseline (28.4%) and 165 (16.3%) at year 20. Longitudinally, for every 1-unit greater risky family, the odds of attaining high CVH (≥10) decreased by 3.6% (OR, 0.9645 [95% CI, 0.94–0.98]). Each unit greater child abuse and caregiver warmth score corresponded to 12.8% lower and 11.7% higher odds of ideal CVH (≥10), respectively (OR, 0.872 [95% CI, 0.77–0.99]; OR, 1.1165 [95% CI, 1.01–1.24]), across all 20 years of follow-up. Stratified analyses by income in adulthood demonstrated associations between risky family environment and CVH remained significant for those of the highest adult income (>$74k), but not the lowest (<$35k). Conclusions: Although risky family environmental factors in childhood increase the odds of poor longitudinal adult CVH, caregiver warmth may increase the odds of CVH, and socioeconomic attainment in adulthood may contextualize the level of risk. Toward a paradigm of primordial prevention of cardiovascular disease, childhood exposures and economic opportunity may play a crucial role in CVH across the life course.

show abstract

Section: Covariatesmentioning

confidence: 93%

Evidence for the Association Between Adverse Childhood Family Environment, Child Abuse, and Caregiver Warmth and Cardiovascular Health Across the Lifespan: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Ortiz,

Kershaw,

Zhao

et al. 2024

Circ: Cardiovascular Quality and Outcomes

View full text Add to dashboard Cite

show abstract

“…Liquor has also been referred to as “hard alcohol” or “spirits” as documented in a previous MESA study. 23 …”

Section: Methodsmentioning

confidence: 99%

Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of Atherosclerosis

Kazibwe,

Chevli,

Evans

et al. 2023

JAHA

Self Cite

View full text Add to dashboard Cite

Background The relationship between alcohol consumption and ectopic fat distribution, both known factors for cardiovascular disease, remains understudied. Therefore, we aimed to examine the association between alcohol consumption and ectopic adiposity in adults at risk for cardiovascular disease. Methods and Results In this cross‐sectional analysis, we categorized alcohol intake among participants in MESA (Multi‐Ethnic Study of Atherosclerosis) as follows (drinks/day): <1 (light drinking), 1 to 2 (moderate drinking), >2 (heavy drinking), former drinking, and lifetime abstention. Binge drinking was defined as consuming ≥5 drinks on 1 occasion in the past month. Visceral, subcutaneous, and intermuscular fat area, pericardial fat volume, and hepatic fat attenuation were measured using noncontrast computed tomography. Using multivariable linear regression, we examined the associations between categories of alcohol consumption and natural log‐transformed fat in ectopic depots. We included 6756 MESA participants (62.1±10.2 years; 47.2% women), of whom 6734 and 1934 had chest computed tomography (pericardial and hepatic fat) and abdominal computed tomography (subcutaneous, intermuscular, and visceral fat), respectively. In adjusted analysis, heavy drinking, relative to lifetime abstention, was associated with a higher (relative percent difference) pericardial 15.1 [95% CI, 7.1–27.7], hepatic 3.4 [95% CI, 0.1–6.8], visceral 2.5 [95% CI, −10.4 to 17.2], and intermuscular 5.2 [95% CI, −6.6 to 18.4] fat but lower subcutaneous fat −3.5 [95% CI, −15.5 to 10.2]). The associations between alcohol consumption and ectopic adiposity exhibited a J‐shaped pattern. Binge drinking, relative to light‐to‐moderate drinking, was also associated with higher ectopic fat. Conclusions Alcohol consumption had a J‐shaped association with ectopic adiposity. Both heavy alcohol intake and binge alcohol drinking were associated with higher ectopic fat.

show abstract

“…beer, wine, or distilled spirits) [ 37 ]. Drinking patterns may be a confounding factor as well [ 44 - 46 ]. Binge drinking increases cardiovascular risk, while many studies suggest that alcohol consumed in moderation is beneficial for the cardiovascular system [ 47 - 49 ].…”

Section: Introductionmentioning

confidence: 99%

Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases

Ceci

Ceccanti²,

Petrella

et al. 2021

CNR

View full text Add to dashboard Cite

: Lipoprotein disorders are a major risk factor for atherosclerotic neuro-cardiovascular disease (ACVD) and are heavily influenced by lifestyle, including alcohol drinking. Moderate drinkers have a lower ACVD risk than abstainers because of their higher levels of high-density lipoprotein (HDL) cholesterol, an important protective factor against ACVD. On the contrary, heavy drinking increases ACVD risk. According to a large literature body, ethanol intoxication modifies lipid serum profile and induces endothelial dysfunction. Single nucleotide polymorphisms may influence the relationship between alcohol drinking, HDL cholesterol level, and atherosclerotic risk. The risk of ACVD in heavy drinkers seems enhanced in patients with apolipoprotein E4 allele, interleukin-6-174 polymorphism, and cholesteryl ester transfer protein TaqIB polymorphism. Apolipoprotein E4 is a known risk factor for ACVD, while apolipoprotein E2 has mixed effects. Therefore, even if a "protective role" may be attributed to moderate drinking, this effect cannot be extended to everyone.

show abstract

Alcohol type and ideal cardiovascular health among adults of the Multi-Ethnic Study of Atherosclerosis

Cited by 11 publications

References 41 publications

Evidence for the Association Between Adverse Childhood Family Environment, Child Abuse, and Caregiver Warmth and Cardiovascular Health Across the Lifespan: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Evidence for the Association Between Adverse Childhood Family Environment, Child Abuse, and Caregiver Warmth and Cardiovascular Health Across the Lifespan: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Association Between Alcohol Consumption and Ectopic Fat in the Multi‐Ethnic Study of Atherosclerosis

Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases

Contact Info

Product

Resources

About