Alcohol Use and Abuse Secondary to Anxiety

Wesner, Robert B.

doi:10.1016/s0193-953x(18)30344-7

Cited by 21 publications

(10 citation statements)

References 31 publications

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“…Between 22% and 33% of children from the community and 60 -75% in clinic referred children with conduct disorder also have an anxiety disorder (Russo and Beidel, 1994;Zoccolillo, 1992). Moreover, evidence for an association between alcoholism and anxiety has emerged from clinical studies of patients with alcoholism (Stockwell et al, 1984;Weiss and Rosenberg, 1985), and those of patients with anxiety disorders (Wesner, 1990). Recent family studies have confirmed that there is an increased risk of alcoholism among relatives of anxiety neurotics (Harris et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

Dopamine D2 Receptor Gene (DRD2) Is Associated With Alcoholism With Conduct Disorder

Lee

et al. 2001

Alcoholism Clin & Exp Res

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This study examined whether there is evidence for an association between alcoholism with conduct disorder and alleles of the TaqI A and TaqI B polymorphisms, both individually and as haplotypes, at the dopamine D2 receptor gene (DRD2). We studied 182 Han Chinese subjects, including 34 alcoholics with conduct disorder, 63 alcoholics without conduct disorder, and 85 nonalcoholics. Alcohol dependence and conduct disorder were defined according to DSM-III-R criteria. Significant associations were observed between TaqI A and TaqI B at the DRD2 locus, tested individually and as haplotypes, and alcoholism with conduct disorder. Our results suggested that DRD2 might be associated with conduct disorder or a predisposition to both conduct disorder and alcoholism. However, this needs to be further investigated by examining the differences among conduct disorder with alcoholism, conduct disorder only, and controls for the TaqI A and B system at DRD2.

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Section: Discussionmentioning

confidence: 99%

Dopamine D2 Receptor Gene (DRD2) Is Associated With Alcoholism With Conduct Disorder

Lee

et al. 2001

Alcoholism Clin & Exp Res

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“…Children who are more likely to exhibit one or more anxiety disorders and/or clinical depression may be at increased risk for developing AUD (Cockerham et al 1989; Crum et al 2008; Vaglum et al 1987; reviewed by Wesner 1990). Internalizing problems in childhood, particularly childhood separation anxiety disorder, have been found to be associated with later development of alcoholism (Brückl et al 2007).…”

Section: Pathways To Alcohol Use Disordersmentioning

confidence: 99%

Neural Circuitry Associated with Risk for Alcohol Use Disorders

Tessner

Hill

2009

Neuropsychol Rev

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The core features of risk for alcohol use disorders (AUD), including behavioral disinhibition, affective dysregulation, and executive dysfunction, map onto distinct neural circuits that have been found to be abnormal in the offspring of alcohol dependent individuals. Components of the cerebellothalamocortical system and the extended limbic network may provide the underpinnings for the behavioral and emotional dysfunction observed in individuals at heightened risk for AUD. In addition, abnormalities in these structures appear to be altered in individuals with the predisposition for other psychiatric conditions that may share a similar genetic diathesis. This review proposes several neurobehavioral mechanisms of genetic vulnerability that may account for phenotypic characteristics in individuals at risk for AUD.

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“…Furthermore, there is strong evidence for genetic factors playing a role in alcoholism and weaker though considerable evidence for genetic factors in other forms of substance dependence [42]. Familial associations be tween alcoholism and certain anxiety syndromes (most notably agoraphobia) are also evident [41,43]. Ingraham and Wender [44] found a significantly greater incidence of affective disorders and substance abuse in the biologi cal relatives of adoptees with affective disorders.…”

Section: One or More Antecedent Factors Predispose To Distinct Disordmentioning

confidence: 99%

Comorbidity of Mental Disorders and Substance Use Disorders

Wittchen

Perkonigg

Reed³

1996

Eur Addict Res

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Recent major epidemiological surveys in general population samples throughout the world have demonstrated that substance use disorders are among the most frequent forms of mental disorders in the community, and are also frequently associated with other forms of mental disorders. This paper briefly reviews the concept of comorbidity and summarizes more recent data concerning the frequency of comorbidity of substance use disorders. The review is limited to studies in the general population using standardized diagnostic interviews. Specific emphasis is laid upon the most recent data from the National Comorbidity Survey, that specifically addressed comorbidity issues in detail. The clear majority of subjects with a definite substance use disorder according to the strict DSM-III-R definition has or has had at least one other comorbid mental disorder. Comorbidity rates between specific substance use disorders and other mental disorders will be compared and discussed in light of several other international epidemiological studies. Furthermore time sequences of substance use disorders and comorbid disorders are presented. Potential pathogenetic and clinical implications are addressed.

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Alcohol Use and Abuse Secondary to Anxiety

Cited by 21 publications

References 31 publications

Dopamine D2 Receptor Gene (DRD2) Is Associated With Alcoholism With Conduct Disorder

Dopamine D2 Receptor Gene (DRD2) Is Associated With Alcoholism With Conduct Disorder

Neural Circuitry Associated with Risk for Alcohol Use Disorders

Comorbidity of Mental Disorders and Substance Use Disorders

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