Alcohol use disorder with comorbid anxiety disorder: a case report and focused literature review

Abstract

Background Alcohol use disorder (AUD) and anxiety disorders (AnxD) are prevalent health concerns in clinical practice which frequently co-occur (AUD-AnxD) and compound one another. Concurrent AUD-AnxD poses a challenge for clinical management as approaches to treatment of one disorder may be ineffective or potentially counterproductive for the other disorder. Case Presentation We present the case of a middle-aged man with anxiety disorder, AUD, chronic pain, and gamma-hydroxybutyrate use in context of tapering prescribed benzodiazepines who experienced severe alcohol withdrawal episodes during a complicated course of repeated inpatient withdrawal management. After medical stabilization, the patient found significant improvement in symptoms and no return to alcohol use with a regimen of naltrexone targeting his AUD, gabapentin targeting both his AUD and AnxD, and engagement with integrated psychotherapy, Alcoholics Anonymous, and addictions medicine follow-up. Conclusion Proper recognition and interventions for AUD and AnxD, ideally with overlapping efficacy, can benefit individuals with comorbid AUD-AnxD. Gabapentin, tobacco cessation, and integrated psychotherapy have preliminary evidence of synergistic effects in AUD-AnxD. Meta-analysis evidence does not support serotoninergic medications (e.g. selective serotonin reuptake inhibitors) which are commonly prescribed in AnxD and mood disorders as their use has not been associated with improved outcomes for AUD-AnxD. Additionally, several double-blind placebo-controlled randomized trials have suggested that serotonergic medications may worsen alcohol-related outcomes in some individuals with AUD. Areas for future investigation are highlighted.

Moderate or major anxiety and depression versus high alcohol consumption in women in Honduras

“…There is a strong association between anxiety versus risky alcohol use, Esmaeelzadeh et al, found significant associations between anxiety and alcohol consumption [20], studies show that anxiety disorders are more common among women, while AUD is more common among men [21], a study of Canadian adults through an online survey in May 2020, found that women were more likely to increase alcohol consumption (41.0%) and anxiety, during the COVID-19 pandemic [22]. AUD and anxiety disorders (AnxD) are prevalent health problems that frequently coexist (AUD-AnxD) and are combined with each other [23], with evidence that for women experiencing intimate partner violence (IPV), psychological therapies likely reduce depression and may reduce anxiety [24].…”

Moderate or major anxiety and depression versus high alcohol consumption in women in Honduras.

“…and are combined with each other (22), withevidence that for women experiencing intimate partner violence (IPV), psychological therapies likely reduce depression and may reduce anxiety (23).…”

A Case Report on Alcohol Dependence Syndrome with Relation to Insomnia

“…Consequently, despite issues associated with alcohol use, there is persistent alcohol use in alcohol dependence [6]. They also experience panic disorder, speci ic phobia, obsessive-compulsive disorder, generalized anxiety disorder (GAD), social anxiety disorder (SAD), post-traumatic stress disorder (PTSD), and panic disorder [7].…”