Alcohol Use in Pregnancy

DeJong, Katherine N; Olyaei, Amy; Lo, Jamie O.

doi:10.1097/grf.0000000000000414

Cited by 131 publications

(88 citation statements)

References 98 publications

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“…Perinatal exposure to alcohol can affect in utero neurodevelopment, causing both physical and functional long-term alterations (Dejong et al, 2019 ). Despite pre-conceptional alcohol cessation is recommended, alcohol drinking during pregnancy is prevalent worldwide, especially in Europe (Popova et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…One of the best predictors of alcohol use throughout the perinatal period is the pattern of alcohol use before pregnancy; indeed, women who report binge or heavy drinking prior to pregnancy likely maintain it during pregnancy and throughout lactation (Davidson et al, 1981 ; Ethen et al, 2009 ; Mallard et al, 2013 ; Anderson et al, 2014 ; Kitsantas et al, 2014 ), increasing the risk for growth deficits, facial dysmorphology, and behavioral and neurocognitive abnormalities in the progeny (Viljoen et al, 2005 ; May et al, 2007 ; Urban et al, 2008 ). Aside from the more severe fetal alcohol syndrome (FAS), “fetal alcohol spectrum disorders” (FASD) have been recently characterized as a broad range of deficits observed in the child when exposed to alcohol at any time prenatally (Dejong et al, 2019 ). Those alterations involve memory, attention, affective and social behavior, abnormal responses to stress and natural rewards (American Psychiatric Association, 2013 ), and susceptibility to drug and alcohol abuse later in life (Baer et al, 2003 ; Alati et al, 2006 ; Glantz and Chambers, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

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Environmental Enrichment During Adolescence Mitigates Cognitive Deficits and Alcohol Vulnerability due to Continuous and Intermittent Perinatal Alcohol Exposure in Adult Rats

Brancato

Castelli

Lavanco

et al. 2020

Front. Behav. Neurosci.

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Perinatal alcohol exposure affects ontogenic neurodevelopment, causing physical and functional long-term abnormalities with limited treatment options. This study investigated long-term consequences of continuous and intermittent maternal alcohol drinking on behavioral readouts of cognitive function and alcohol vulnerability in the offspring. The effects of environmental enrichment (EE) during adolescence were also evaluated. Female rats underwent continuous alcohol drinking (CAD)-or intermittent alcohol drinking paradigm (IAD), along pregestation, gestation, and lactation periods-equivalent to the whole gestational period in humans. Male offspring were reared in standard conditions or EE until adulthood and were then assessed for declarative memory in the novel object recognition test; spatial learning, cognitive flexibility, and reference memory in the Morris water maze (MWM); alcohol consumption and relapse by a two-bottle choice paradigm. Our data show that perinatal CAD decreased locomotor activity, exploratory behavior, and declarative memory with respect to controls, whereas perinatal IAD displayed impaired declarative memory and spatial learning and memory. Moreover, both perinatal alcohol-exposed offspring showed higher vulnerability to alcohol consummatory behavior than controls, albeit perinatal IAD rats showed a greater alcohol consumption and relapse behavior with respect to perinatal-CAD progeny. EE ameliorated declarative memory in perinatal CAD, while it mitigated spatial learning and reference memory impairment in perinatal-IAD progeny. In addition, EE decreased vulnerability to alcohol in both control and perinatal alcohol-exposed rats. Maternal alcohol consumption produces drinking pattern-related

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Environmental Enrichment During Adolescence Mitigates Cognitive Deficits and Alcohol Vulnerability due to Continuous and Intermittent Perinatal Alcohol Exposure in Adult Rats

Brancato

Castelli

Lavanco

et al. 2020

Front. Behav. Neurosci.

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“…Alcohol consumption and tobacco smoke remain the main risk factors for reproduction [26][27][28]. Evidence in the scientific literature is beginning to show possible interactions between tobacco exposure and environmental exposures and even with exposures to passive maternal smoking [29].…”

Section: Discussionmentioning

confidence: 99%

The ARTEMIS Center: An Environmental Health Prevention Platform Dedicated to Reproduction

Delva

Manangama

Brochard

et al. 2020

IJERPH

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In France, a new approach is being developed through the ARTEMIS Center, which is a prevention platform for environmental health dedicated to reproduction. The objective is to describe the clinical management of patients in the ARTEMIS center. Couples with a condition affecting reproduction are referred to the ARTEMIS center. Management includes a medical consultation and a standardized interview. Current exposure is assessed by a questionnaire that includes exposure circumstances to reproductive risk factor and on the basis of which it is possible to implement preventive action in clinical practice without prejudging the role of such exposure in the onset of disease. From 16 February 2016 to 2 May 2019, 779 patients were seen in the ARTEMIS center. On the day of the consultation, 88.3% men and 72.2% women were employed. Among employed men, 61.5% had at least one instance of occupational exposure to a reproductive risk factor, and among employed women, 57.8%. The main nonprofessional circumstances of exposure identified were proximity of the residence to an agricultural area (35.3%) and domestic pesticide exposure (79.7%). The preventive actions implemented by the ARTEMIS center are targeted to the individual practices of patients. However, patient care also allows their physicians to become familiarized with environmental health.

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“…While there are numerous articles warning of the dangers of alcohol during pregnancy (Burden, Jacobson, and Jacobson 2005; Charness et al 2016; Connor and Streissguth 1996; Day and Richardson 1991; DeJong, Olyaei, and Lo 2019; D’Onofrio et al 2007; Flak et al 2014; Kesmodel et al 2019; Lupton, Burd, and Harwood 2004; Zuccolo et al 2013), they share similar problems. As recent exemplars, here we focus our attention specifically on the scientific studies that lead to the 2016 CDC warning and the JAMA article that became the basis of an NYT article.…”

Section: The Studiesmentioning

confidence: 99%

Fetal Alcohol Syndrome Warnings: Policing Women’s Behavior Distorts Science

Killian

Thomas

2020

Journal of Applied Social Science

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This article focuses on the recent resurgence of concerns regarding fetal alcohol syndrome (FAS). A report from the Centers for Disease Control and Prevention (CDC) warning even women not trying to conceive to abstain from alcohol completely if not using contraceptives, and a medical article covered by the New York Times that claims that rates of FAS are much higher than previously thought, have reignited anxiety over FAS, even though there remains substantial gray area in the relationship between alcohol and pregnancy outcomes. Not only is there scant evidence that less than a drink a day affects offspring, and none that an occasional drink during pregnancy has any effect, even among alcoholic women, FAS is more than 10 times more likely to strike the children of poor alcoholics than those of higher means who drink excessively. We explore why researchers, physicians, and public health officials continue to hyperbolize the effects of drinking alcohol leading to recommendations that target not just alcoholic women, but all women, pregnant or not. Building on past authors’ suspicion of previous overblown cautioning about FAS, we do in-depth tracing of the bibliographic lineage of these warnings, highlighting the problems with the medical researchers’ and health agencies’ recommendations including extending the scope of the problem and relying on misleading statistics. We argue that while policing women’s bodies to insure compliance with “proper” feminine behavior is an ongoing phenomenon, these new attacks on women’s autonomy veiled in scientific language must be unmasked and challenged.

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Alcohol Use in Pregnancy

Cited by 131 publications

References 98 publications

Environmental Enrichment During Adolescence Mitigates Cognitive Deficits and Alcohol Vulnerability due to Continuous and Intermittent Perinatal Alcohol Exposure in Adult Rats

Environmental Enrichment During Adolescence Mitigates Cognitive Deficits and Alcohol Vulnerability due to Continuous and Intermittent Perinatal Alcohol Exposure in Adult Rats

The ARTEMIS Center: An Environmental Health Prevention Platform Dedicated to Reproduction

Fetal Alcohol Syndrome Warnings: Policing Women’s Behavior Distorts Science

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